Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and use of Syringa pubescens bark extract

A technology of clove and its extract, which is applied in the research and development field of its pharmaceutical products, and can solve the problems that the research on the antioxidant activity of clove bark has not been reported yet.

Inactive Publication Date: 2011-02-09
SHANDONG UNIV AT WEIHAI
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on antioxidant has become a hot spot, but the research on the antioxidant activity of clove bark has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and use of Syringa pubescens bark extract
  • Preparation method and use of Syringa pubescens bark extract
  • Preparation method and use of Syringa pubescens bark extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Get 100 g of the 40-mesh powder of the clove bark, extract it with 6 times the amount of 70% ethanol at room temperature for 8 hours, and let it stand and filter;

[0020] (2) Repeat the above steps with 8 times the amount and 6 times the amount of 70% ethanol respectively for the filter residue, and sonicate for 30 minutes;

[0021] (3) merging the filtrate, reclaiming the solvent to obtain the total extract;

[0022] (4) Extract the total extract 3 times with sherwood oil, ethyl acetate and water-saturated n-butanol respectively;

[0023] (5) respectively merging petroleum ether layer, ethyl acetate layer and n-butanol layer extract;

[0024] (6) (5) petroleum ether layer, ethyl acetate layer and n-butanol layer extract are concentrated under reduced pressure respectively, and freeze-dried to obtain clove bark petroleum ether layer extract, ethyl acetate layer extract, n-butanol layer extract.

[0025] (7) The extracts from (6) the petroleum ether layer, the et...

Embodiment 2

[0027] (1) Get 200 g of the 40-mesh powder of the clove bark, extract it with 8 times the amount of 70% ethanol at room temperature for 10 hours, and let it stand and filter;

[0028] (2) Repeat the above steps with 8 times the amount and 6 times the amount of 70% ethanol respectively for the filter residue, and sonicate for 30 minutes;

[0029] (3) merging the filtrate, reclaiming the solvent to obtain the total extract;

[0030] (4) Extract the total extract 3 times with sherwood oil, ethyl acetate and water-saturated n-butanol respectively;

[0031] (5) respectively merging petroleum ether layer, ethyl acetate layer and n-butanol layer extract;

[0032] (6) (5) petroleum ether layer, ethyl acetate layer and n-butanol layer extract are concentrated under reduced pressure respectively, and freeze-dried to obtain clove bark petroleum ether layer extract, ethyl acetate layer extract, n-butanol layer extract.

[0033] (7) The extracts from (6) the petroleum ether layer, the e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicinal product research and development. The invention relates to a preparation method and use of Syringa pubescens bark extract. The method comprises: leaching 40-mesh Syringa pubescens bark powder with 70-percent ethanol in an amount which is 6 to 8 times that of the Syringa pubescens bark powder at room temperature for 8 to 10 hours, standing and filtering; leaching the filter residue with 70-percent ethanol in an amount which is 8 times that of the filter residue, leaching the filter residue with 70-percent ethanol in an amount which is 6 times that of the filter residue, performing ultrasonic treatment for 30 minutes, combining filtrate, recovering solvent and obtaining total extract; extracting the total extract with petroleum ether, ethyl acetate, water saturated n-butyl alcohol respectively at three times; and combining the petroleum ether layer extract solution, the ethyl acetate extract solution and the n-butyl alcohol extract solution, concentrating under vacuum, performing freeze drying, and obtaining the petroleum ether layer extract, ethyl acetate extract and n-butyl alcohol extract of the Syringa pubescens bark. The product of the invention has a remarkable removing effect on hydroxyl radicals, can be developed into a natural antioxidant medicament to be used as a substitute for synthetic antioxidant in treating diseases caused by an overlarge amount of radicals in the body.

Description

technical field [0001] The invention belongs to the technical field of research and development of pharmaceutical products. The invention relates to a preparation method and application of a clove bark extract. Background technique [0002] Syringa Pubescens Turcz., also known as Qiaoling flower, sparrow flower, and hairy lilac, is a plant of the genus Syringa in the family Oleaceae. It is distributed in Henan, Hebei, Shaanxi, Shanxi, Gansu and other places in my country. It grows in Mountains, valleys or cliffs at an altitude of 800-2400m. The folks have known its medicinal value for a long time. They used to pick its flowers and fruits to make tea for drinking. It has anti-inflammatory, antitussive, and curative effects on hepatitis and cirrhosis, but it has not been included in the pharmacopoeia so far. At present, there are few reports on the research on the plant of Lilac microphylla at home and abroad, and the research on the bark is even rarer. [0003] Free radical...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K129/00A61P39/06A61K36/185
Inventor 张崇禧徐蕊张岩张腾杨淑超孙丽陈晓芳郑友兰
Owner SHANDONG UNIV AT WEIHAI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com