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Process and apparatus for producing a tabletting aid and also a tabletting aid and tabletting mixture

An auxiliary agent and tablet-making technology, which is applied in the direction of medical preparations of non-active ingredients, pill delivery, pharmaceutical formulations, etc., can solve the problems of low tablet hardness, tablet coverage, over-mixing danger, etc., and achieve low ejection force , saving production time and cost, evenly distributed effect

Inactive Publication Date: 2014-11-05
J RETTENMAIER & SOEHNE GMBH CO KG ROSENBERG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many different reasons for this, starting with the danger of overmixing, very low tablet hardness and tablet coverage

Method used

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  • Process and apparatus for producing a tabletting aid and also a tabletting aid and tabletting mixture
  • Process and apparatus for producing a tabletting aid and also a tabletting aid and tabletting mixture
  • Process and apparatus for producing a tabletting aid and also a tabletting aid and tabletting mixture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0044] Tableting aids according to the invention were compared in a placebo (Placebo), 40% acetaminophen (Paracetamol) and enalapril (Enalapril) with a list of physical mixtures consisting of the individual components. The results are given in Tables 2, 3 and 4.

[0045] ·Placebo tablets

[0046]

[0047] ★ Tableting aids according to the invention are only compressed at different pressures.

[0048] ★★ All components except PRUV were mixed for 15 minutes. Lubricant was then added, mixed for an additional 3 minutes and compacted at various pressures.

[0049] Table 2: Direct comparison between tableting aid (granulate 1) and physical mixture consisting of a single component;

[0050] Placebo List

[0051]

[0052] The DC-tabletting aids according to the invention show significantly better compressibility and tablet hardness, lower ejection forces and less abrasion than physical blends (Table 2, figure 1 and 2 ).

[0053] Acetaminophen (Paracetamol) tablets

[0...

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Abstract

The invention concerns a process for the production of a tableting excipient with the following process steps: At least two of the following components are made available: A filler / binding agent; A lubricant; A flow regulating agent; A disintegrant; The available components are mixed together.

Description

technical field [0001] The present invention relates to a method, a preparation and a material according to the above title. Background technique [0002] Direct compression is a commonly used method for preparing tablets. The method consists of different mixing steps. Firstly the active substance and all auxiliary substances (mainly fillers, binders and disintegrants) are mixed with one another except the lubricant. This can be done in a separate mixing step, in which the filler, binder and disintegrant are added together to the effect substance. Instead of this it is also possible to carry out a plurality of successive mixing steps. The lubricant is then added to the mixture and mixed with it again. The result is a tabletting mixture. The tableting mixture is compressed on a tablet machine. [0003] Combined auxiliary materials (direct tableting auxiliaries) are present in pharmaceutical technology. These are combined tableting adjuvants which are prepared from indi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J2/16A61K9/20
CPCB01J2/16A61K47/38A61K9/2095
Inventor 埃德蒙特·斯托亚诺夫赖因哈德·福尔默托比亚斯·戈茨
Owner J RETTENMAIER & SOEHNE GMBH CO KG ROSENBERG
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