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Process for preparing non-toxic extractive from asarum heterotropoides

A preparation process and extract technology, which are applied in the field of preparation technology of non-toxic extract of Asarum chinensis, can solve problems such as waste of traditional Chinese medicine resources, and achieve the effects of saving resources, shortening production cycle and having strong compatibility.

Inactive Publication Date: 2011-03-30
SHENYANG PHARMA UNIVERSITY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] At present, the medicinal part of Asarum is the root, and the above-ground part is mostly discarded, resulting in a waste of traditional Chinese medicine resources

Method used

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  • Process for preparing non-toxic extractive from asarum heterotropoides

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Embodiment 1

[0027] Take 500g of the whole herb of Asarum, crush it until it passes through a 5-mesh sieve. Put it in an extraction tank, add 5000ml of distilled water, heat and reflux for extraction 3 times, reflux for 2 hours each time, combine the extracts, and filter.

[0028] The pH of the extract was adjusted to 10.0 with NaOH and allowed to stand for 0.5 hours. The extract was passed through a pretreated 213-type ion exchange resin column (500 g), and the effluent 1 was collected.

[0029] The pH of Effluent 1 was adjusted to 3.0 with HCl and allowed to stand for 0.5 hours. The effluent 1 was passed through a pretreated 731-type ion exchange resin column (500 g), and the effluent 2 was collected.

[0030] The pH of the effluent 2 was adjusted to 7.0 with NaOH and allowed to stand for 0.5 hours. Pass the effluent 2 through the pretreated D101 macroporous adsorption resin column (500g), and discard the effluent 2.

[0031] Use 10000ml of 75% ethanol to elute the macroporous adsorp...

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Abstract

The invention relates to a process for removing toxic and harmful components from herbal medicines and extracting effective components from the herbal medicines, in particular to a process for preparing non-toxic extractives from asarum heterotropoides, belonging to the field of pharmaceutical technology. The preparation process for preparing the non-toxic extractives from the asarum heterotropoides comprises the following steps of: decocting a whole asarum heterotropoides plant by using hot water for extraction; cooling filer liquor; adding HCl and NaOH to regulate a pH value; and removing the toxic components, i.e. volatile safrole and nonvolatile components, such as aristolochic acid and aconitine, nor-aconitine and the like, out of asarum heterotropoides medicinal materials and effectively retaining the effective components through the purification steps of cation exchange resin, anion exchange resin, and the like. The invention can simultaneously remove multiple toxic and harmful components contained in the asarum heterotropoides medicinal materials together, obviously shorten the production period and reduce the production cost; in addition, a detoxification process has the advantages of strong compatibility, simple process, low energy consumption and resource saving without environment pollution in the production process.

Description

Technical field: [0001] The invention relates to the removal of toxic and harmful components of Chinese herbal medicines and the preparation process of active components, in particular to a preparation process for preparing non-toxic extracts from Asarum asarum. Background technique: [0002] North Asarum ( Asarum heterotropoldes Fr. Schmidt var. mandshuricum (Maxim.) Kitag.) belongs to Aristolochiaceae, perennial herb. It is a commonly used traditional Chinese medicine. Herba Asari nature and flavor: warm in nature, pungent in the mouth. "Shen Nong's Materia Medica" is listed as top grade. Asarum has a slender root, a spicy smell, a spicy taste, and a numbness to the tongue. North Asarum grows in hillside forests and shrubs in damp places. It can tolerate severe cold and is mainly distributed in Liaoning, Jilin, and Heilongjiang provinces; there are also a small amount of distribution in Shaanxi, Shanxi, Hebei, and Shandong provinces. North Asarum is also known as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/264A61P9/00A61P25/00A61P29/00A61P31/04A61P37/02
Inventor 孙博航吴立军高慧媛黄健
Owner SHENYANG PHARMA UNIVERSITY
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