74 results about "Safrole" patented technology

The present invention relates to a method for the preparation of a layer of a plasma-polymerised material on the surface of a substrate, e.g. a substrate of a glass, an organosiloxane-based or polysiloxane-based material, silicon, fluoro-polymer (e.g. Teflon®), etc. The present invention also relates to novel objects and microstructured or micro-patterned devices, e.g. by lift-off techniques, in particular such objects and devices that have layers of electrically conducting materials providing a conductivity of at least 0.01 S / cm. A feature of the invention is the plasma-polymerization of a compound including at least one polycyclic compound, said polycyclic compound(s) comprising a non-aromatic heterocyclic ring fused to an aromatic or heteroaromatic ring or ring system. Examples of such compounds are 3,4-ethylenedioxythiophene (EDT) forming layers of poly(ethylenedioxythiophene) (PEDT), and piperonylamine, piperonyloyl chloride, safrole, 3,4-ethylenedioxypyrrole, 3,4-ethylenedioxy-N-methylpyrrole, and 3,4-methylenedioxythiophene.

The invention provides an analgesic and refreshing herbal composition useful as dentrifrices, said composition comprising 50-60% Wt. of betle extract (from Piper betle leaves); 40-50% Wt. of one or more group I essential oil selected from Levender officinal, Dementholised oil (ex-Mentha arvensis), Fennel oil and Ocimum gratissimum; 3.5-6% Wt. of one or more group II essential oils and their isolates selected from Ocimum Sanctum, Pulegone (ex Mentha pulegonium), Carvone (ex. Dill seed) and Menthol (ex. Mentha arvensis); 1-5% Wt. of one or more group III essential oils selected from Camphor, turpentine oil, Cedarwood oil and Safrole oil, along with 0.5-2% Wt. of Thymol and 0.25-1% Wt. of preservative / antioxidant, and a process for preparing the composition.

Methods for removing safrole from a sample, molecular imprinted copolymers that bind safrole, and methods of making the same are provided.

The invention discloses a quick measurement method for coumarin and safrole in essence and flavor. The quick measurement method comprises the steps of performing oscillation extraction on an essence and flavor sample by taking ethyl alcohol aqueous solution as a solvent, filtering an extracting solution through an organic filtering film, and measuring the coumarin and the safrole through ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS). The quick measurement method has the characteristics that difficulties in quantified separation and purification of a complicated mixture system are avoided through quantification by an isotope dilution internal standard method; the ethyl alcohol aqueous solution is used as the sample extraction solvent, so that the extraction efficiency is guaranteed, and the amount of organic impurities, which enter a chromatographic column, in small samples is reduced; furthermore, the chromatographic column is effectively protected; compared with the conventional method, the UPLC-MS / MS is high in analysis speed, high in repetitiveness and high in recycling rate, and is suitable for analysis of a large batch of samples.

The production process of alpha-asarone includes the following production stages: acetylation reaction, methylation reaction, hydroformylation reaction, vinylation reactin and re-crystallization. The artificial synthesis process of alpha-asarone has high yield of alpha-asarone, low cost, high purity up to 98.5 %, no carcinogenic substance safrole contained in the volatile oil, no toxic matter and no side effect and can meet clinical requirement.

This invention publics a detecting method about a nontoxic traditional medicine liao asarum. It is to extract volatile oil according to a method of volatile oil extraction from Chinese pharmacopeia, the 2000 edition, dissolve by cyclohexane, and inject it into gas-chromatograph-mass spectrometer to draft fingerprint pattern. Through the analysis result by computer, it is to get 28-wave crest, such as methyleugenol, safrole myristicin and so on, where the essential component methyleugenol is about 37 percent. The volatile oil extracted according to pharmacopeia is dissolved by acetic ester, added methyl alcohol, and injected into high efficiency liquid chromatography to get high efficiency liquid fingerprint pattern. It is to adopt liquid hypersonic extracted for 30 minutes by methyl alcohol-water (3:1) ,and inject it into high efficiency liquid chromatography to build detecting method about high efficiency liquid chromatogram for aristolochic acid.

The invention discloses a method for detecting seven prohibited compounds in flavors and fragrances. The seven prohibited compounds are methanol, sec-butyl alcohol, safrole, imidazole, coumarin, musk xylene and sesamol. The detection method can accurately and rapidly detect the contents of the seven prohibited compounds in flavors and fragrances, is suitable for quality safety control of fragrance raw liquid and auxiliary solvents in the industries such as food, daily-use chemical industry, tobacco and pharmacy, and the has the characteristics of simple operation, rapidness, accuracy, good repeatability, high sensitivity and the like.

This invention relates to dihydro safrole preparation method. Catechol is used as material, goal product if got through propionyltion, reducing and methylenation three steps reaction. The technique condition is mild, generating cost is low, product whole yield is high, purity is high, so it is good preparation method that has wide industrial prospect.

The invention discloses a method for measuring safrole in mainstream smoke of cigarettes. The method comprises the steps of preparation of an internal standard solution, a standard working solution and a sample solution, gas chromatography-tandem mass spectrometry analysis, calculation of measurement results and the like. According to the invention, N-heptadecane is used as an internal standard substance for quantifying, the optimized detection method is extremely sensitive in response and accurate in quantitative analysis and effectively reduces the interference caused by complex sample matrix; the adopted chromatography and mass spectrometry conditions enable the target substance to have good signal response and good linear correlation, the detection limit is 0.015ng / cigarette, the relative standard deviation (RSD) is 6.35%, and the adding standard recovery is 87.78-110.9%, thus the method is high in sensitivity, good in repeatability and high in recovery rate and is suitable for quantitative analysis of the safrole serving as a trace target substance in the complex matrix of the smoke.

The invention belongs to the technical field of biological medicine, in particular relates to a method for preparing an antidiabetic preparation by taking cinnamon as the raw material. The method comprises the following steps: pulverizing cinnamon, extracting the pulverized cinnamon with an ester soluble solvent, or boiling the pulverized cinnamon with water or a water-ethanol solution, then extracting with the ester soluble solvent, dissolving safrole as a toxic component in the ester soluble solvent, and distilling the extracted cinnamon powder or the extracted solution to acquire a powdery substance, i.e. the antidiabetic preparation.

The invention provides a method for measuring the contents of coumarin and safrole in tobacco products. The method comprises the steps of carrying out ultrasonic extraction, filtering with an organic filter membrane and microextraction on the tobacco products to obtain a tobacco product solution to be measured; and performing gas chromatography-mass spectrometry detection on the tobacco product solution to be measured, thus obtaining the contents of coumarin and safrole in the tobacco products according to an acquired chromatogram of the tobacco product and preset standard curves of coumarin and safrole, so that the effect of simultaneously measuring coumarin and safrole in the tobacco products is achieved. The method can rapidly and accurately measure the contents of coumarin and safrole in the tobacco products, reduces the matrix effects and improves the separation degree of coumarin and safrole by adopting the microextraction technology; and the method has simplicity and convenience in operation.

The invention discloses a making method of a graphene electrothermal film analgesic external plaster. The plaster comprises a graphene electrothermal film and a gel drug layer arranged in the middle of the upper surface of the graphene electrothermal film; gel drugs are positioned on the gel drug layer; the gel drugs comprise a drug composition and an adjuvant material substrate, wherein the adjuvant material substrate is amphiphilic gel; the drug composition is prepared from the following components: fructus corni, azalea flower, white paeony root, red paeony root, echinacea purpurea, marigold flower, aesculus chinensis extract, echinacea purpurea moench ethanol extract, rhizoma arnicae montanae, safrole and a peppermint extract. The analgesic external plaster provided by the invention has functions of promoting local blood circulation and physically treating chronic pain, and is suitable for alleviating various chronic and old pains such as low back pain, neck pain and joint pain which are caused by falling injury, sprains and strains.

The invention discloses a high performance liquid chromatography fluorescence detection method for simultaneously measuring four prohibited and limited additives in tobacco flavors and perfumes. The high performance liquid chromatography fluorescence detection method comprises the following steps: firstly performing oscillating extraction on the tobacco flavors and perfumes by using alcohol, standing to pass through a 0.45 micrometer organic phase filtering membrane to obtain a to-be-detected sample solution; and simultaneously preparing standard solutions of the four prohibited and limited additives, respectively performing detection analysis on the to-be-detected sample solution and the standard solutions by adopting a high performance liquid chromatography fluorescence detector, and then performing quantitative analysis by adopting an external standard method, figuring out contents of the four prohibited and limited additives in the tobacco flavors and perfumes, wherein the four prohibited and limited additives comprise sesamol, beta-naphthol, beta-asarone and safrole. According to the high performance liquid chromatography fluorescence detection method, simultaneous measurement of the four prohibited and limited additives in the tobacco flavors and perfumes is realized. Because special chromatographic columns for phenols are used, the detection time is relatively short; the fluorescence detector is adopted, the selectivity is relatively high, the matrix interference is relatively small, the detection limit is relatively low; no water removal is needed before treatment, and the relative simplicity is achieved in operation.

The invention discloses a method for preparing 3,4-methylenedioxophenyl-2-acetone from a benzofuranol side product, namely, 4-(2-methylallyl)-1,2-dihydroxybenzene which is used as a raw material and is from the residue in a benzofuranol rectifying still, and the method can be used for solving the problem of utilizing the resource of the benzofuranol side product, namely, the 4-(2-methylallyl)-1,2-dihydroxybenzene. The content of the obtained 3,4-methylenedioxophenyl-2-acetone is 98.3-99.5%, the total yield reaches 71.0-85.7%, and the problems of high production cost, environment pollution and the like of other methods using safrole as a raw material are solved. Equation is shown in the specification.

This invention relates to dihydro safrole preparation method. Catechol is used as material, goal product if got through propionyltion, reducing and methylenation three steps reaction. The technique condition is mild, generating cost is low, product whole yield is high, purity is high, so it is good preparation method that has wide industrial prospect.

Methods for removing safrole from a sample, molecular imprinted copolymers that bind safrole, and methods of making the same are provided.

The invention provides a method for removing safrole from myristica oil. The method comprises the following steps: separating commercially available myristica oil serving as a raw material through molecular distillation, obtaining a safrole-free light component 1# and a safrole-enriched heavy component 2#, further carrying out silica gel chromatography on the heavy component 2#, carrying out leaching through a nonpolar solvent and ethyl acetate mixed solution, collecting safrole-free eluant, removing a solvent from the safrole-free eluant, and mixing the solvent-removed safrole-free eluant with the safrole-free light component 1#, thus obtaining the safrole-removed myristica oil. According to the method for removing the safrole from the myristica oil, the safrole in the myristica oil can be effectively removed, and the content of the safrole in the refined myristica oil is less than 1 mug / g, and the product safety and the application range are substantially improved. A preparation method is simple in operation process, low in cost and suitable for industrial production.

The invention discloses a method for converting safrole into iso-safrole. The method comprises the following steps: performing isomerization reaction on the safrole and a NaOH-containing basic catalyst under the condition of pressurization to generate the iso-safrole, wherein the basic catalyst is NaOH / gamma-Al2O3 or NaOH / CaO, the addition amount is 1-5 percent of the weight of the safrole, the NaOH-containing basic catalyst can be a NaOH solution of which the mass percentage concentration is 5-60%, and the use amount is 0.2-0.8% of the weight of the safrole; performing neutralization, washing, vacuum rectification and the like on the isomerized coarse iso-safrole to obtain high-purity iso-safrole of which the purity is more than 99.8 percent. The method has the advantages that the reaction time is short, the use amount of alkali is small, long-time high-temperature contact between the alkali and air is avoided, side reactions such as oxidative polymerization are reduced, and the yield of the iso-safrole is improved.

The invention provides asarum volatile oil, which is prepared by a method including steps of extracting asarum to obtain volatile oil crude product, separating by a vacuum distillation method at pressure of 0.06MPa, collecting distillate when temperature is increased per 8 DEG C from 36 DEG C, sealing the distillate into a brown bottle, marking 1-7 number, marking number 8 for the undistilled volatile oil, storing at low temperature, detecting that bottle with number 7 contains safrole, discarding; mixing the remained distillate and the volatile oil with number 8 to prepare the volatile oil of the present invention. The invention also provides use of the volatile oil. The invention can remain effective components while removing most safrole by a vacuum distillation method, clinical use is safer, by separating different components of the volatile oil and dispensing, medicine effect is more unambiguous and stable, controllability is strong, and the invention has advantages of low cost, simple instrument and easy operation, can be popularized in production, and provides a new clinical selection.

The present invention provides a method for identifying whether a to-be-detected sample is derived from antrodia camphorate or cinnamomum micranthum, which comprises the steps of detecting the contents of 4-terpineol, camphor and safrole in the volatile components of the to-be-detected sample. If the content of 4-terpineol is larger than the total content of camphor and safrole, the to-be-detected sample is derived from antrodia camphorate. If the content of safrole is larger than the content of camphor and the content of camphor is larger than the content of 4-terpineol, the to-be-detected sample is derived from cinnamomum micranthum.

The invention relates to a process for removing toxic and harmful components from herbal medicines and extracting effective components from the herbal medicines, in particular to a process for preparing non-toxic extractives from asarum heterotropoides, belonging to the field of pharmaceutical technology. The preparation process for preparing the non-toxic extractives from the asarum heterotropoides comprises the following steps of: decocting a whole asarum heterotropoides plant by using hot water for extraction; cooling filer liquor; adding HCl and NaOH to regulate a pH value; and removing the toxic components, i.e. volatile safrole and nonvolatile components, such as aristolochic acid and aconitine, nor-aconitine and the like, out of asarum heterotropoides medicinal materials and effectively retaining the effective components through the purification steps of cation exchange resin, anion exchange resin, and the like. The invention can simultaneously remove multiple toxic and harmful components contained in the asarum heterotropoides medicinal materials together, obviously shorten the production period and reduce the production cost; in addition, a detoxification process has the advantages of strong compatibility, simple process, low energy consumption and resource saving without environment pollution in the production process.

The invention discloses an antibacterial collagen preparation method based on epoxidation modification of safrole. According to the method, safrole is modified with a weak epoxidation reagent, and themodified safrole is covalently introduced into collagen by using the covalent reaction between the epoxy group and the amino group on the side chain of the collagen macromolecule, such that the collagen substrate has good antibacterial activity. According to the present invention, the collagen material obtained by using the modification method has the long-lasting antibacterial function, whereinthe three-stranded spiral structure of the collagen substrate cannot be destroyed, and the inherent biocompatibility can be completely retained, such that the application prospect in the collagen-based biomedical material field is broad.

The invention provides asarum volatile oil, which is prepared by a method including steps of extracting asarum to obtain volatile oil crude product, dissolving the volatile oil into ether, using 10% hydrochloric acid, 5% sodium bicarbonate, 1-2% sodium hydroxide and 30-40% sodium hydrogen sulfite to extract sequentially to obtain alkaline component, strong acidic component, weak acidic component, aldehyde, ketone and neutral oil component, mixing the four components except the neutral oil component, storing at low temperature to obtain the asarum volatile oil. The invention also provides use of the asarum volatile oil. The invention can remain effective components while removing most safrole by a system solvent extraction separation method, clinical use is safer, by separating different components in the volatile oil and dispensing, medicine effect is more unambiguous and stable, controllability is strong, and the invention has advantages of low cost, simple instrument and easy operation, can be popularized in production, and provides a new clinical selection.

The invention discloses a sodium phosphate oral solution composition and a preparation method of the sodium phosphate oral solution composition. The raw materials for preparing the oral solution composition comprise disodium hydrogen phosphate, ginger juice, lemon juice, phosphoric acid, glycerin and purified water, and the addition amounts of the raw materials for preparing each liter of the oral solution composition are as follows: 2.5 to 250g of phosphoric acid, 5 to 7g of the ginger juice and 4 to 6g of the lemon juice; the weight of disodium hydrogen phosphate is 1.4-1.6 times of that of phosphoric acid, and the weight of the glycerin is 4%-6% of that of phosphoric acid. The preparation comprises the following steps: firstly adding disodium hydrogen phosphate and glycerin into purified water, then adding the ginger juice and lemon juice, then adding phosphoric acid, stirring heating to 60-65 DEG C, digesting for 0.5-1 hour, finally adding purified water to fix volume and uniformly stirring. The sodium phosphate oral solution composition disclosed by the invention can effectively inhibit ginger to generate and transform carcinogen safrole and promote a gastrointestinal medicine guiding effect of ginger components, has an obvious synergistic effect and a good intestine cleaning effect, can further relieve gastrointestinal discomfort, can be used as a mild and safe intestine cleaning product and further can be used as a medicine, food and drink.

The invention provides a safrole hapten, an artificial antigen, an antibody as well as a preparation method and application of the safrole hapten, the artificial antigen and the antibody, two haptens, namely a hapten H-SG and a hapten H-2C are prepared, the hapten H-SG is coupled with carrier protein BSA to obtain the artificial antigen H-SG-BSA, and the specific antibody for detecting safrole is further prepared. An artificial antigen H-2C-OVA is used as a coating antigen; the lowest detection limit of the antibody to safrole is 0.088 ng / mL, the half inhibitory concentration is 2.79 ng / mL, the quantitative detection range is 0.31-24.74 ng / mL, the antibody has good sensitivity and specificity, has no cross reaction to safrole analogues, and can specifically detect safrole; the invention provides a better immunodetection raw material of safrole, and provides a better choice for rapid and accurate detection of safrole.

The invention provides a method for removing safrole from borneol oil. The method comprises the following steps: (1) pre-treating a column separation filling, putting the filling into a column, and putting the borneol oil into the column; and (2) carrying out elution by virtue of an elution agent, and concentrating, so as to obtain borneol essential oil in which safrole is removed. The method is strong in operability and can be applied to direct expanded production, ''three wastes'' are not generated, the content of dextro-borneol is remarkably increased in the purified borneol essential oil,the purified borneol essential oil has relatively pure fragrance, and the method has wide application prospects and relatively high application values.

Provided is a lemon juice-containing beverage which gives a fresh sensation typical of lemon regardless of its low fruit juice content. One ppb or more of at least one phenylpropene selected from the group consisting of safrole, methyleugenol, and myristicin is incorporated in a lemon juice-containing beverage having a fruit juice content of not less than 1% and not more than 30% and comprising at least one aroma component selected from the group consisting of linalool, nonanal, and decanal.

The catalytic hydrogenation process of preparing dihydrosafrole is one with reaction temperature of 15-100 deg.c, hydrogen pressure of 0.5-2.5 MPa, C1-C4 lower fatty alcohol and / or C6-C10 arene as solvent, and skeleton copper carrying P and at least one of B, VIB, VIII and RE elements as catalyst. The process has higher dihydrosafrole yield and less solvent consumption compared with available dihydrosafrole preparing processes and may be used in industrial production.