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Method for measuring safrole in mainstream smoke of cigarettes

A technology of cigarette mainstream smoke and safrole, which is applied to measuring devices, instruments, scientific instruments, etc., can solve the problems of low safrole release level and analysis interference, and achieve the effects of reducing errors, ensuring accuracy and improving sensitivity

Inactive Publication Date: 2014-10-08
CHINA TOBACCO JIANGSU INDAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for cigarette samples, due to the low level of safrole release in the smoke and the serious interference of the complex matrix of the smoke on the analysis of the target, the accurate determination of the release of safrole is an important task in the field of smoke analysis. Challenging work

Method used

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  • Method for measuring safrole in mainstream smoke of cigarettes
  • Method for measuring safrole in mainstream smoke of cigarettes
  • Method for measuring safrole in mainstream smoke of cigarettes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A method for measuring safrole in cigarette mainstream smoke, flow chart as figure 1 shown, including the following steps:

[0036] (1) Preparation of internal standard solution

[0037]Internal standard stock solution: Accurately weigh 0.202g of internal standard n-heptadecane, dilute to 100mL with ethanol to obtain an internal standard stock solution with a concentration of 2020μg / mL; internal standard solution: accurately pipette 0.1mL of internal standard stock solution, and dilute to 100 mL with ethanol to obtain an internal standard solution with a concentration of 2.02 μg / mL.

[0038] (2) Preparation of standard working solution

[0039] Primary standard stock solution: accurately weigh 0.1069g of safrole, and dilute to 100mL with ethanol to obtain a primary standard stock solution with a concentration of 1069μg / mL; secondary standard stock solution: accurately pipette 0.1mL primary standard stock solution, Dilute to 100mL with ethanol to obtain a secondary st...

Embodiment 2

[0061] Taking a cigarette sample as the analysis object, adopt the method of embodiment 1 to measure the content of target substance, carry out precision test, measure altogether 6 times, calculate the relative standard deviation (RSD) of 6 parallel determination results respectively, measurement result is shown in Table 3 . The results in the table show that the RSD of the repeatability of the experimental method is less than 10%. For the analytical detection of trace substances, the method has good precision.

[0062] Table 3 Precision of the method

[0063] serial number

Determination result (ng / branch)

1

0.176

2

0.192

3

0.190

4

0.191

5

0.177

6

0.209

RSD(%)

6.35

[0064] Taking a cigarette sample as an object, carry out standard addition treatment at three different concentration levels of low, medium and high, and then process according to the above standard pretreatment step...

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Abstract

The invention discloses a method for measuring safrole in mainstream smoke of cigarettes. The method comprises the steps of preparation of an internal standard solution, a standard working solution and a sample solution, gas chromatography-tandem mass spectrometry analysis, calculation of measurement results and the like. According to the invention, N-heptadecane is used as an internal standard substance for quantifying, the optimized detection method is extremely sensitive in response and accurate in quantitative analysis and effectively reduces the interference caused by complex sample matrix; the adopted chromatography and mass spectrometry conditions enable the target substance to have good signal response and good linear correlation, the detection limit is 0.015ng / cigarette, the relative standard deviation (RSD) is 6.35%, and the adding standard recovery is 87.78-110.9%, thus the method is high in sensitivity, good in repeatability and high in recovery rate and is suitable for quantitative analysis of the safrole serving as a trace target substance in the complex matrix of the smoke.

Description

technical field [0001] The invention belongs to the technical field of detection of physical and chemical indicators of cigarettes, and in particular relates to a method for measuring safrole in mainstream smoke of cigarettes. Background technique [0002] Safrole is a colorless or light yellow liquid. It has camphor wood smell, easily soluble in ethanol, miscible with chloroform and ether, insoluble in water and glycerin. The relative density is 1.096, the freezing point is about 11°C, the boiling point is 232-234°C, the refractive index is 1.5383, the flash point is 97°C, and the median lethal dose (rat, oral) is 1950mg / kg. [0003] Safrole is the main component of many edible natural flavors such as sassafras essential oil, star anise essential oil and camphor oil, accounting for about 80% of sassafras essential oil. Safrole is also found in small amounts in fragrances made with spices such as nutmeg, Japanese wild ginger, and California laurel. Sassafras essential oil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 廖惠云庄亚东石怀彬李朝建曹毅王珂清尤晓娟张媛韩开冬朱龙杰朱莹秦艳华
Owner CHINA TOBACCO JIANGSU INDAL
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