Asarum volatile oil prepared by system solvent method and use thereof

An asarum volatile oil and a technology for volatile oil, applied in the field of asarum volatile oil and its preparation, can solve the problems of incapability of large-scale preparation, complex volatile oil components, inability to be widely used, etc., and achieve the effects of low cost, clear medicinal effect and easy operation.

Inactive Publication Date: 2009-09-16
SICHUAN NORMAL UNIVERSITY
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Problems solved by technology

But the content of safrole in the volatile oil prepared by this method is still relatively high; there are bibliographical reports to carry out the target removal of strong toxic component safrole in the n-hexane extract of Asarum by high performance liquid chromatography, and adopt Horn's method and Xylene-induced ear shell swelling test in mice before and after the removal of the extract before and after acute toxicity and anti-inflammatory pharmacological activity research (Cheng Mengchun, et al., a new method for specifically removing toxic components of Asarum by preparative liquid chromatography, World Science and Technology-Modern Modern Basic Research of Traditional Chinese Medicine, 2006, Volume 8, Phase 2), although safrole can be effectively removed by long-time coo

Method used

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  • Asarum volatile oil prepared by system solvent method and use thereof
  • Asarum volatile oil prepared by system solvent method and use thereof
  • Asarum volatile oil prepared by system solvent method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1 Preparation of Asarum volatile oil of the present invention

[0029] 1 Extraction of volatile oil:

[0030] Grind the whole herb of the Asarum plant sample, pass through a 40-mesh sieve, extract the volatile oil according to the volatile oil extraction method in the Chinese Pharmacopoeia, separate it after fully standing, collect the oil-water mixture, and extract a light yellow oily liquid. Seal it with a brown bottle and store it in a -10°C refrigerator.

[0031] 2 component separation:

[0032] Dissolve the volatile oil in diethyl ether, extract the volatile oil diethyl ether with 10% hydrochloric acid to obtain an acidic water layer, alkalize it and extract it with diethyl ether, distill off the diethyl ether to obtain the basic component;

[0033] The ether layer was washed with water and extracted with 5% sodium bicarbonate to obtain an alkaline aqueous layer, which was acidified and extracted with ether, and the ether was distilled off to obtain a ...

Embodiment 2

[0039] Embodiment 2 The content determination of methyl eugenol, safrole in volatile oil of the present invention

[0040] Adopt gas chromatography normalization method to measure the relative content of methyl eugenol and sassafras in volatile oil in embodiment 1, references: Wang Dong, etc., methyl eugenol and sassafras quantitative analysis in different growth stages of Herba Asari , Chromatography, the 15th phase of the 15th volume in January, 1997; Described method is measured, and the result: the weight percentage that contains methyl eugenol in the volatile oil that embodiment 1 prepares is 35.7%; The weight percentage of safrole was 3.1%.

[0041] Prove beneficial effect of the present invention by pharmacodynamic test below.

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Abstract

The invention provides asarum volatile oil, which is prepared by a method including steps of extracting asarum to obtain volatile oil crude product, dissolving the volatile oil into ether, using 10% hydrochloric acid, 5% sodium bicarbonate, 1-2% sodium hydroxide and 30-40% sodium hydrogen sulfite to extract sequentially to obtain alkaline component, strong acidic component, weak acidic component, aldehyde, ketone and neutral oil component, mixing the four components except the neutral oil component, storing at low temperature to obtain the asarum volatile oil. The invention also provides use of the asarum volatile oil. The invention can remain effective components while removing most safrole by a system solvent extraction separation method, clinical use is safer, by separating different components in the volatile oil and dispensing, medicine effect is more unambiguous and stable, controllability is strong, and the invention has advantages of low cost, simple instrument and easy operation, can be popularized in production, and provides a new clinical selection.

Description

technical field [0001] The invention relates to asarum volatile oil, a preparation method and application thereof, and belongs to the field of medicines. Background technique [0002] The dry whole plant of Aristolochiaceae Asarum heterotropoides Fr.Schmidtvat.mandshuricum(Maxim.)Kitag. Asarum is a commonly used traditional Chinese medicine, which has pharmacological activities such as antipyretic, anti-inflammatory, analgesic, and sedative, and its main active ingredient is volatile oil. Such as: Research on the analgesic and anti-inflammatory effects of three kinds of Asarum volatile oils, Chinese Journal of Traditional Chinese Medicine (formerly Chinese Journal of Medical Sciences), 2006, Volume 21, No. 5; Research Progress of Asarum Ether, Journal of Traditional Chinese Medicine, 2006 July, Volume 24, Issue 7, reported various activities of asarone on nervous system, cardiovascular system, respiratory system, digestive system, etc. For the extraction process of Asarum,...

Claims

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Application Information

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IPC IPC(8): A61K36/264A61P29/00A61P37/02A61P19/04
Inventor 严伟郭益许志晖黄蕊
Owner SICHUAN NORMAL UNIVERSITY
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