Method for preparing antidiabetic preparation by taking cinnamon as raw material

An anti-diabetic and cinnamon technology, applied in the field of biomedicine, can solve problems such as the accumulation effect of safrole, and achieve the effects of economy and practicality, speeding up metabolism, and simple extraction method.

Inactive Publication Date: 2009-12-02
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term consumption of cinnamon, the safrole in it has an accumulation effect, if the toxic component safrole in cinnamon is not removed, long-term use as an anti-diabetic product will have serious consequences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: After 10 kilograms of cinnamon are pulverized, extract with 10 times of normal hexane, and reflux extraction in the extraction tank, after the extraction is completed, remove the extract, safrole is dissolved in the extract, and the solvent is recovered by distillation with a distiller. can be used again. The resulting toxic substance safrole can be used for other purposes. The extracted cinnamon powder was dried and pulverized again to obtain 9.5 kg of refined cinnamon powder after removing the toxic substance safrole. The obtained cinnamon powder can be prepared into antidiabetic tablets, capsules, honeyed pills, powders and other commonly used dosage forms.

Embodiment 2

[0022] Example 2: first crush 5kg of cinnamon, then boil with water 5 times the weight of the raw material for 3 hours, and filter out the boiling liquid; then add water 4 times the weight of the raw material to continue boiling the filter residue for 2 hours; filter the boiling liquid , then add water 3 times the weight of the raw material to continue boiling the filter residue for 2 hours, filter to obtain the filtrate. The filtrates obtained three times were combined and concentrated in a water distiller to obtain a concentrated solution, and the three concentrated solutions were combined to 500 ml in total. Use 2500ml of petroleum ether to extract 3-5 times or multiple times to remove the liver carcinogen safrole in cinnamon. The extracted aqueous solution was vacuum distilled again to obtain a powder state extract, which was vacuum-dried to obtain 186 grams of light brown powder total flavanones and their multimers. The extraction rate is 3.72%. The obtained total flava...

Embodiment 3

[0023] Embodiment 3: first 20kg of cinnamon is pulverized, then reflux boiling with 6 times of ethanol 20%-water 80% of raw material weight for 3 hours, and the boiling liquid is filtered out; then add 5 times of ethanol 20%-water 80% of raw material weight Continue boiling the filter residue under reflux for 2 hours; filter the boiling liquid, add 20% ethanol-80% water 3 times the weight of the raw material, continue boiling the filter residue for 2 hours, filter to obtain the filtrate. The three obtained filtrates were combined and concentrated in a water distiller to obtain a concentrated solution, and the three concentrated solutions were combined to a total of 1500 ml. Use 4500ml of petroleum ether to extract 3-5 times or multiple times to remove the liver carcinogen safrole in cinnamon. The extracted aqueous solution was subjected to vacuum distillation again to obtain a powder extract, which was vacuum-dried to obtain 820 grams of light brown powder total flavanones and...

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PUM

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Abstract

The invention belongs to the technical field of biological medicine, in particular relates to a method for preparing an antidiabetic preparation by taking cinnamon as the raw material. The method comprises the following steps: pulverizing cinnamon, extracting the pulverized cinnamon with an ester soluble solvent, or boiling the pulverized cinnamon with water or a water-ethanol solution, then extracting with the ester soluble solvent, dissolving safrole as a toxic component in the ester soluble solvent, and distilling the extracted cinnamon powder or the extracted solution to acquire a powdery substance, i.e. the antidiabetic preparation.

Description

[0001] Field [0002] The invention belongs to the technical field of biomedicine, and in particular relates to a method for preparing an antidiabetic preparation using cinnamon as a raw material. Background technique [0003] Diabetes mellitus is a group of clinical syndromes caused by the interaction of genetic and environmental factors. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissue cells to insulin lead to a series of metabolic disorders such as sugar, protein, fat, water and electrolytes. [0004] According to the World Health Organization (WHO) statistics, there are at least 120 million diabetics worldwide. In developed countries such as Europe and the United States, diabetes is a high incidence rate, and its mortality rate ranks third after cardiovascular diseases and tumors. There are about 20 million to 30 million people with diabetes in China. Although it belongs to a country with a low incidence of diabetes, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P3/10A61K129/00
Inventor 吴凤锷陈斌
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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