Asarum volatile oil prepared by vacuum distillation method and use thereof

Abstract

The invention provides asarum volatile oil, which is prepared by a method including steps of extracting asarum to obtain volatile oil crude product, separating by a vacuum distillation method at pressure of 0.06MPa, collecting distillate when temperature is increased per 8 DEG C from 36 DEG C, sealing the distillate into a brown bottle, marking 1-7 number, marking number 8 for the undistilled volatile oil, storing at low temperature, detecting that bottle with number 7 contains safrole, discarding; mixing the remained distillate and the volatile oil with number 8 to prepare the volatile oil of the present invention. The invention also provides use of the volatile oil. The invention can remain effective components while removing most safrole by a vacuum distillation method, clinical use is safer, by separating different components of the volatile oil and dispensing, medicine effect is more unambiguous and stable, controllability is strong, and the invention has advantages of low cost, simple instrument and easy operation, can be popularized in production, and provides a new clinical selection.

Description

technical field [0001] The invention relates to asarum volatile oil, a preparation method and application thereof, and belongs to the field of medicines. Background technique [0002] The dry whole plant of Aristolochiaceae Asarum heterotropoides Fr.Schmidtvat.mandshuricum(Maxim.)Kitag. Asarum is a commonly used traditional Chinese medicine, which has pharmacological activities such as antipyretic, anti-inflammatory, analgesic, and sedative, and its main active ingredient is volatile oil. Such as: Research on the analgesic and anti-inflammatory effects of three kinds of Asarum volatile oils, Chinese Journal of Traditional Chinese Medicine (formerly Chinese Journal of Medical Sciences), 2006, Volume 21, No. 5; Research Progress of Asarum Ether, Journal of Traditional Chinese Medicine, 2006 July, Volume 24, Issue 7, reported various activities of asarone on nervous system, cardiovascular system, respiratory system, digestive system, etc. For the extraction process of Asarum,...

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Problems solved by technology

But the content of safrole in the volatile oil prepared by this method is still relatively high; there are bibliographical reports to carry out the target removal of strong toxic component safrole in the n-hexane extract of Asarum by high performance liquid chromatography, and adopt Horn's method and Xylene-induced ear shell swelling test in mice before and after the removal of the extract before and after acute toxicity and anti-inflammatory pharmacological activity research (Cheng Mengchun, et al., a new method for specifically removing toxic components of Asarum by preparative liquid chromatography, World Science and Technology-Modern Modern Basic Research of Traditional Chinese Medicine, 2006, Volume 8, Phase 2), although safrole can be effectively removed by long-time cooking, but at the same time, the main medicinal components of Asarum such as methyl eugenol will also be removed The cost of removing safrole with liquid chromatography is high and cannot be prepared on a large scale, so it cannot be widely used in production applications

[0004] What is reported in the current literature is to directly extract Asarum volatile oil as a medicinal part, but due to the complexity of the components in the volatile oil, in addition to the active ingredients, there are also toxic ingredients, such as sassafras, and among the active ingredients, various ingredients play the role of medicine. There are different effects, and there is no report in the relevant literature on the further separation of Asarum volatile oil and the monitoring of drug efficacy.

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