Asarum volatile oil prepared by vacuum distillation method and use thereof

A technology of Asarum volatile oil and volatile oil, which is applied in the field of Asarum volatile oil and its preparation, which can solve the problems of incapability of large-scale preparation, complex components of volatile oil, and inability to be widely used, and achieve the effects of low cost, clear drug effect, and easy operation

Inactive Publication Date: 2009-09-16
SICHUAN NORMAL UNIVERSITY
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the content of safrole in the volatile oil prepared by this method is still relatively high; there are bibliographical reports to carry out the target removal of strong toxic component safrole in the n-hexane extract of Asarum by high performance liquid chromatography, and adopt Horn's method and Xylene-induced ear shell swelling test in mice before and after the removal of the extract before and after acute toxicity and anti-inflammatory pharmacological activity research (Cheng Mengchun, et al., a new method for specifically removing toxic components of Asarum by preparative liquid chromatography, World Science and Technology-Modern Modern Basic Research of Traditional Chinese Medicine, 2006, Volume 8, Phase 2), although safrole can be effectively removed by long-time coo

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Asarum volatile oil prepared by vacuum distillation method and use thereof
  • Asarum volatile oil prepared by vacuum distillation method and use thereof
  • Asarum volatile oil prepared by vacuum distillation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The extraction of embodiment 1 Asarum volatile oil of the present invention

[0020] 1. Water distillation to extract crude volatile oil

[0021] The test drug Asarum was purchased from Hangzhou Traditional Chinese Medicine Decoction Factory, and was identified as the dried whole plant of Asarumheterotropoides Fr. Schmidt vat. mandshuricum (Maxim.) Kitag.

[0022] Methods Take Asarum 500g, put it in the volatile oil extractor, add the specified amount of water, soak for a certain period of time, read the volatile oil according to the specified time of "Chinese Pharmacopoeia" 2000 edition, appendix XD volatile oil determination method (method A) steam distillation quantity.

[0023] The distilled volatile oil is collected in a brown bottle and stored at low temperature (5°C).

[0024] In addition to using this method to extract volatile oil, other methods reported in the current literature can also be used to extract volatile oil.

[0025] 2. Separation of volatile oi...

Embodiment 2

[0032] Embodiment 2 The content determination of methyl eugenol, safrole in volatile oil of the present invention

[0033] Adopt gas chromatography normalization method to measure the relative content of methyl eugenol and sassafras in volatile oil in embodiment 1, references: Wang Dong, etc., methyl eugenol and sassafras quantitative analysis in different growth stages of Herba Asari , Chromatography, the 15th phase of the 15th volume in January, 1997; Described method is measured, and the result: the weight percentage that contains methyl eugenol in the volatile oil that embodiment 1 prepares is 46.3%; The weight percentage of safrole was 1.7%.

[0034] Prove beneficial effect of the present invention by pharmacodynamic test below.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides asarum volatile oil, which is prepared by a method including steps of extracting asarum to obtain volatile oil crude product, separating by a vacuum distillation method at pressure of 0.06MPa, collecting distillate when temperature is increased per 8 DEG C from 36 DEG C, sealing the distillate into a brown bottle, marking 1-7 number, marking number 8 for the undistilled volatile oil, storing at low temperature, detecting that bottle with number 7 contains safrole, discarding; mixing the remained distillate and the volatile oil with number 8 to prepare the volatile oil of the present invention. The invention also provides use of the volatile oil. The invention can remain effective components while removing most safrole by a vacuum distillation method, clinical use is safer, by separating different components of the volatile oil and dispensing, medicine effect is more unambiguous and stable, controllability is strong, and the invention has advantages of low cost, simple instrument and easy operation, can be popularized in production, and provides a new clinical selection.

Description

technical field [0001] The invention relates to asarum volatile oil, a preparation method and application thereof, and belongs to the field of medicines. Background technique [0002] The dry whole plant of Aristolochiaceae Asarum heterotropoides Fr.Schmidtvat.mandshuricum(Maxim.)Kitag. Asarum is a commonly used traditional Chinese medicine, which has pharmacological activities such as antipyretic, anti-inflammatory, analgesic, and sedative, and its main active ingredient is volatile oil. Such as: Research on the analgesic and anti-inflammatory effects of three kinds of Asarum volatile oils, Chinese Journal of Traditional Chinese Medicine (formerly Chinese Journal of Medical Sciences), 2006, Volume 21, No. 5; Research Progress of Asarum Ether, Journal of Traditional Chinese Medicine, 2006 July, Volume 24, Issue 7, reported various activities of asarone on nervous system, cardiovascular system, respiratory system, digestive system, etc. For the extraction process of Asarum,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/264A61P29/00A61P19/04A61P37/02C11B3/12B01D3/14
Inventor 严伟郭益许志晖黄蕊
Owner SICHUAN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap