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Cordyceps militaris oligopeptide composition as well as preparation method and use thereof

The technology of a composition and Cordyceps militaris is applied to health care products and cosmetics, and the composition is in the field of medicine, which can solve the problems of low protein bioavailability, unfavorable, insufficient purity of active ingredients, etc., so as to improve immunity, Prevention and treatment of hypertension, the effect of unique biological functions

Active Publication Date: 2011-04-06
BEIJING INST OF OLIGO PEPTIDE BIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Cordyceps preparations obtained by these methods contain a large number of unnecessary substances. In addition, the purity of its active ingredients is still not enough, especially the protein usually retains almost complete macromolecular forms.
Bioavailability of proteins in macromolecular forms is generally low, which is disadvantageous in the nutritional and cosmetic industry

Method used

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  • Cordyceps militaris oligopeptide composition as well as preparation method and use thereof
  • Cordyceps militaris oligopeptide composition as well as preparation method and use thereof
  • Cordyceps militaris oligopeptide composition as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0058] 1. Preparation of Cordyceps militaris Fruiting Body Powder

[0059] The fruiting body of Cordyceps militaris was placed in a low-temperature vacuum drying oven, dried at 55°C for 16 hours, and crushed into a 100-mesh fine powder by a crusher.

[0060] 2. Preparation and Extraction of Cordyceps Fruiting Body Oligopeptide

[0061] Mix fruit body fine powder and deionized water at a ratio of 1:12.5, stir and heat to 95°C, and keep warm for 15 minutes. After the heat preservation was completed, the temperature was rapidly lowered to 50°C, and 500,000 u / g alkaline protease of 1% by weight of the fruiting body dry weight was added, the pH was adjusted to 8.5 with 10% NaOH solution, and the temperature was kept at 50°C for 3 hours. After the incubation, add 150,000 u / g neutral protease at 1% by weight of fruiting body dry weight, adjust the pH to 7.3 with 10% NaOH solution, and incubate at 50°C for 3h. After the incubation, add 50,000 u / g of pepsin at 1% by weight of fruit ...

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Abstract

The invention relates to a method for extracting a composition containing nano-oligopeptide from cordyceps militaris as well as the composition extracted by the method. In the method, the cordyceps militaris is hydrolyzed by a complex enzymatic method to obtain the small molecular nano-oligopeptide. The invention is characterized in that the molecular weight of the nano-oligopeptide is mainly distributed within 100-1000D; and preferably the Gaussian distribution peak area percentage of the nano-oligopeptide the molecular weight of which is 100-500 D in the composition is more than 50%. The cordyceps militaris oligopeptide extract provided by the invention reserves other active ingredients such as cordycepin, ecdysone, adenosine, cordyceps polysaccharide, cordycepic acid, trace elements, vitamins and free amino acid. The invention further relates to an application of the composition containing the nano-oligopeptide extracted from the cordyceps militaris in preparing medicines, healthcare products and cosmetics.

Description

technical field [0001] The invention relates to a method for extracting nanometer oligopeptides from Cordyceps militaris and a composition extracted by the method. The invention also relates to the application of the nano oligopeptide-containing composition extracted from Cordyceps militaris in medicine, health products and cosmetics. Background technique [0002] Cordyceps sinensis is a fungus of the family Ergotaceae ( Cordycceps sinensis ) and its parasitic main bat moth ( Heplalus armaricanus ) complex of larval corpses. Modern pharmacological experiments have proved that Cordyceps sinensis has anti-aging, immunity-enhancing, anti-cancer, anti-virus, anti-convulsant and sedative effects, androgen-like effects, and also has protective effects on the cardiovascular and cerebrovascular systems. Due to the limitation of growth conditions, the output of natural Cordyceps is limited, wild resources have been over-excavated, and the output has been decreasing year by year, ...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61K38/02A61K38/16A61K8/99A61K8/64C12P21/06A23J3/14A23L1/305A61P5/26A61P9/00A61P25/08A61P25/20A61P31/12A61P35/00A61P37/04A61P39/06A23L33/105A23L33/16A23L33/175A23L33/18
Inventor 胡如桂杜以波
Owner BEIJING INST OF OLIGO PEPTIDE BIOLOGY
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