Ginkgolides K and compound thereof as well as preparation method and use thereof

A technology of ginkgolides and complexes, which is applied in the field of ginkgolides and their complexes, to achieve the effect of reducing the degree of nuclear dissolution and softening focus

Active Publication Date: 2011-04-06
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no ginkgolide K preparation on the market at home and abroad

Method used

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  • Ginkgolides K and compound thereof as well as preparation method and use thereof
  • Ginkgolides K and compound thereof as well as preparation method and use thereof
  • Ginkgolides K and compound thereof as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1. A preparation method of ginkgolide K, the steps of which are as follows: add ginkgolide B to an alkaline aqueous solution, heat and dissolve in a water bath, and keep warm; after testing that the ginkgolide B is basically completely transformed, then adjust the pH value with an acidic aqueous solution Until the solution becomes acidic, let it stand still, filter to obtain a precipitate, take the precipitate and wash it with water, then dissolve it with an organic solvent, concentrate, and recrystallize until the purity reaches more than 90%.

Embodiment 2

[0086] Example 2. A preparation method of ginkgolide K, the steps of which are as follows: add ginkgolide extract containing ginkgolide B to a mixed solution of alkaline water and alcohol, heat and dissolve in a water bath, and keep warm; after testing, ginkgolide B is basically After the transformation is complete, adjust the pH value with an acidic aqueous solution until the solution is acidic, let it stand still, and centrifuge to obtain a precipitate. The precipitate is washed with water, dissolved in an organic solvent, concentrated, and recrystallized until the purity reaches more than 90%.

Embodiment 3

[0087] Example 3. A preparation method of ginkgolide K, the steps of which are as follows: add ginkgolide B to a water-alcohol mixed solution, heat and dissolve in a water bath, and keep warm; after testing that the ginkgolide B has basically transformed completely, concentrate and crystallize, and obtain The crystals are then dissolved in an organic solvent, concentrated, and recrystallized until the purity reaches more than 90%.

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Abstract

The invention discloses a compound of ginkgolides K of which a general formula is shown in (I), and a composition is prepared by mixing the ginkgolides K compound and pharmaceutically-acceptable medicine carrier, wherein G is alkaline substances. The invention also discloses a preparation method of the compound and treatment use thereof. In the invention, the ginkgolides K compound changes the physical property of the ginkgolides K, thereby the invention has the advantages of good stability, and the ginkgolides K compound has good water-solubility and higher stability. In the compound, a natural structure of the ginkgolides K can be kept, and when the compound is used as an effective component to enter the human body, the activity of the ginkgolides K can be fully developed to achieve theaim of treating an illness.

Description

[0001] This application is a divisional application of CN200510094106.3. The application date of the original application is August 25, 2005. The application number is CN200510094106.3. The name of the invention is: Ginkgolide K and its compound and its preparation method and use . technical field [0002] The invention relates to a ginkgolide substance and a compound thereof; in particular, a ginkgolide K and a compound thereof, and also relates to a preparation method and application of the ginkgolide K and a compound thereof. Background technique [0003] Ginkgolide is an effective substance extracted from the Chinese herbal medicine Ginkgo biloba. The substance can be further subdivided into ginkgolide A, B, C, bilobalide, etc. in terms of structure. The extraction method of ginkgolide has been described in detail. Bibliographical reports, for example, people such as Li Xingang introduced the laboratory extraction method of ginkgolide (seeing Li Xingang etc., the laborat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/22C07C279/14C07C277/08C07C229/26C07C227/16C07C215/10C07C213/08A61K31/365A61P9/10A61P7/02A61P25/28A61P37/06A61P29/00A61P37/08A61P9/00
Inventor 肖伟戴翔翎凌娅李明慧丁岗章晨峰
Owner JIANGSU KANION PHARMA CO LTD
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