Compound preparation containing enalapril for treating hypertension

Abstract

The invention relates to a compound preparation containing enalapril for treating hypertension, comprising main compositions and a matched pharmaceutically acceptable vector, wherein the main compositions include L-amlodipine or a pharmaceutically acceptable salt of the L-amlodipine, hydrochlorothiazide and the enalapril or other pharmaceutically acceptable salt of the enalapril, and the L-amlodipine or the pharmaceutically acceptable salt of the L-amlodipine is contained in each preparation unit. According to an action mechanism that drug combination fully fulfills the function of drug complementarity, the invention increases the curative effect, rapidly reaches the standard with the blood pressure standard-reaching rate of 82 percent, reduces the adverse reaction relative to the increase of a certain dosage and keeps longer action time. The compound preparation has the advantages of fast effect, high blood pressure standard-reaching rate, little side effect and low cost.

Description

Technical field: [0001] The invention relates to a compound preparation containing enalapril for treating hypertension, which belongs to the field of medicines. Background technique: [0002] With the rapid growth of my country's economy, drastic changes in people's lifestyles, and the acceleration of urbanization and aging, cardiovascular disease has become the first or second cause of death in urban and rural populations. Especially the patients with hypertension, whose incidence rate accounts for about 15% of the total population. With such a large disease population, it is more important to seek therapeutic drugs with significant curative effect and less side effects. [0003] At present, there are many drugs for the treatment of hypertension, such as calcium antagonists (CCBs), converting enzyme inhibitors (ACEI), angiotensin Ⅱ receptor blockers (ARBs), etc., but it is difficult to achieve the target for a single drug treatment of hypertension in the short term , most...

AI Technical Summary

Problems solved by technology

However, when several drugs are taken at the same time, the patient's compliance is poor, and the dosage of several drugs is often not the optimal ratio due to the problem of the dosage of the preparation and the degree of recognition of the doctor.

In recent years, although there are many new antihypertensive drugs with good efficacy and few side effects, the rate of blood pressure control is relatively low