New application of prostaglandin compounds

A technology of compounds, uses, applied in the field of pharmaceuticals

Active Publication Date: 2011-04-27
SHANGHAI TECHWELL BIOPHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported that it can be used as a cathartic agent (described in US5317032), but its function of relieving or treating the acc...

Method used

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  • New application of prostaglandin compounds
  • New application of prostaglandin compounds
  • New application of prostaglandin compounds

Examples

Experimental program
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Effect test

Embodiment 1

[0054] 30 μg of lubiprostone was dissolved in medium-chain triglyceride, filled into soft capsules, and each capsule containing 30 μg of lubiprostone was prepared. A total of 60 adult women aged 20-40 were selected and randomly divided into three groups, 20 in each group. They were given this capsule, Chinese herbal detoxification Yangyan capsules and placebo (starch capsules), once a day, one capsule each time, continuously taken On the 40th, observe 4 indicators: acne, pigmentation, skin whitening, and acne reduction.

[0055] 1. Acne removal: (take the number of facial acne as an indicator)

[0056]The reduction of facial acne, acne, blackheads, and acne was more than 2 positions markedly effective, and the size of acne or pox body was reduced by more than 1 / 3 as effective, and the position without change was invalid. The results show that 25% of those taking this capsule are markedly effective, 45% are effective, and 15% are ineffective; 10% are markedly effective, 35% ar...

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Abstract

The invention discloses new application of prostaglandin compounds. The prostaglandin compounds are shown as a formula I and can be used for preparing medicaments for relieving and/or treating vivo toxin accumulation and/or improving skin conditions, wherein R1 is hydrogen atom, C1-C4 straight-chain or branched-chain alkyl, phenyl and any pharmaceutically acceptable salt such as sodium salt, potassium salt, ammonium salt and the like; 13th and 14th sites are carbon-carbon single bond or double bonds; and R2 and R3 express the same or different halogen atoms respectively.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of prostaglandin compounds in relieving or treating accumulation of toxins in the body and improving skin conditions. Background technique [0002] There are often some toxins in the human body due to various factors. If these substances are not excreted from the body in time, they will lead to various diseases, such as acne, gastroenteritis, hepatitis, pigmentation and so on. At present, people mostly use traditional Chinese medicine formulas to improve this situation, but there is no exact composition of traditional Chinese medicine. [0003] Prostaglandins are a general term for a class of fatty acid compounds with various physiological activities. It is widely found in the organs of human and animal tissues, and it generally has the following structural skeleton: [0004] [0005] 15-Keto-16-halogenoprostanoids often exist in monocyclic and bicyclic tautomeric for...

Claims

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Application Information

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IPC IPC(8): A61K31/5575A61K31/558A61P3/06A61P17/00A61P39/06
Inventor 唐志军许天惠郑居上卓忠浩郑云满高霄梁季晓铭
Owner SHANGHAI TECHWELL BIOPHARMACEUTICALS CO LTD
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