Active ingredient composition for treating alcoholic liver injury

A technology for alcoholic liver damage and active ingredients, which is applied in the direction of active ingredients of heterocyclic compounds, medical preparations containing active ingredients, organic active ingredients, etc., which can solve problems such as inconvenient use, difficulty in controlling dosage and safety, and achieve Improve curative effect, clinical dosage and safe and effective, reduce toxic and side effects

Active Publication Date: 2011-04-27
王喜军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a combination of active ingredients for the treatment of alcoholic liver injury in order to solve the problems of inconvenient use, uncontrollable dosage and safety of traditional Chinese medicine and its compound decoction for the treatment of liver injury

Method used

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  • Active ingredient composition for treating alcoholic liver injury
  • Active ingredient composition for treating alcoholic liver injury

Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0010] Specific Embodiment 1: The active ingredient combination for the treatment of alcoholic liver injury in this embodiment consists of 16-20 parts of 6,7-dimethoxycoumarin, 7-11 parts of geniposide and 4 parts by mass. ~8 parts of rhein.

[0011] The main performance indicators of the active ingredient combination for the treatment of alcoholic liver injury in this embodiment:

[0012] 1. Alanine aminotransferase (ALT) indicators:

[0013] ALT is mainly distributed in the liver cytoplasm. If the liver cells are necrotic, alanine aminotransferase will increase, and the degree of increase is consistent with the degree of liver cell damage. Therefore, it is currently one of the most commonly used liver function indicators. one. The increase of ALT activity after ethanol administration indicated the destruction of liver cells and the enhancement of cell membrane permeability. It suggested that the correlation coefficient between the normal physiological state of the rats an...

specific Embodiment approach 2

[0028] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the active ingredient combination for the treatment of alcoholic liver injury consists of 16 parts of 6,7-dimethoxycoumarin, 7 parts of Composed of geniposide and 4 parts of rhein. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0029] Specific embodiment three: the difference between this embodiment and specific embodiment one is that the active ingredient combination for the treatment of alcoholic liver injury consists of 20 parts of 6,7-dimethoxycoumarin, 11 parts of Composed of geniposide and 8 parts of rhein. Others are the same as in the first embodiment.

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Abstract

The invention discloses an active ingredient composition for treating alcoholic liver injury, and relates to an active ingredient composition for treating liver injury. The invention solves the problems that the conventional traditional Chinese medicines and compound decoction thereof for treating liver injury are inconvenient to use, and the dosage and safety are difficult to control. The active ingredient composition for treating the alcoholic liver injury consists of 6,7-dimethoxybenzopyran-2-one, geniposide and parietic acid. The active ingredient composition for treating the alcoholic liver injury has the advantages that: the clinical medicinal dosage is accurate, safe and effective, the active ingredient composition is convenient to use, the treatment effect is improved, medicinal materials are saved, and toxic and side effects are reduced; and the 6,7-dimethoxybenzopyran-2-one, the geniposide and the parietic acid have liver-protecting and gut-benefiting components having the advantages of quick absorption (short time to peak), slow metabolism (longer half life of medicines), higher peak concentration and larger blood concentration area under a curve, so the 6,7-dimethoxybenzopyran-2-one, the geniposide and the parietic acid can serve as preferred active ingredients. The active ingredient composition provides a basis for subsequently preparing finished pharmaceutical products in various formulations.

Description

technical field [0001] The invention relates to a combination of active ingredients for treating liver damage. Background technique [0002] Traditional Chinese medicine and its compound decoction for treating liver damage have certain curative effects, but in clinical application, it is inconvenient to use, and the dosage and safety are difficult to control; taking this kind of medicine is not only time-consuming, but the decoction is subject to many conditions. For example, decoction time, decoction utensils, water addition, heat, decoction first and second decoction methods are difficult to master. The decoction is completely based on experience, which is highly subjective and arbitrary, and lacks reliable quality inspection and monitoring methods. Many uncertain factors make it impossible to guarantee the clinical curative effect; and Chinese patent medicines are generally only aimed at specific groups of people and specific diseases, and cannot be added or subtracted ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/37A61K31/192A61P1/16
Inventor 王喜军孙晖孙文军吕海涛吴革林
Owner 王喜军
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