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Chinese medicine effective component composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as difficult to clarify the curative effect mechanism, complex ingredients, unstable quality, etc., and achieve the effect of saving medicinal materials, clear mechanism, dosage, and safety and effectiveness

Active Publication Date: 2015-08-19
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the compatibility of the existing traditional Chinese medicine formula "Astragalus, Polygonatum, and Ganoderma lucidum" for nourishing qi and nourishing essence. Mechanism is difficult to clarify and other technical problems, but provides a Chinese medicine active component composition and its use

Method used

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  • Chinese medicine effective component composition and application thereof
  • Chinese medicine effective component composition and application thereof
  • Chinese medicine effective component composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1 Screening of the synergistic effect of the effective components of the small compound recipe "Astragalus, Polygonatum, and Ganoderma lucidum" on chemotherapy

[0091] 1 Materials and methods

[0092] 1.1 Experimental materials

[0093] 1.1.1 Main Instruments

[0094] Ultra-clean workbench: American Baker Company

[0095] KA-1000 centrifuge: Shanghai Feige Instrument Co., Ltd.

[0096] HH·W21·600S electric constant temperature water tank: Shanghai Yuejin Medical Devices Co., Ltd.

[0097] Electronic balance: American Ohaus Company

[0098] 10-100μl pipette: Eppendorf, Germany

[0099] Various types of cell culture bottles, petri dishes, cryotubes, pipettes, pipette tips: American Corning Corporation

[0100] 1.1.2 Experimental drugs

[0101] Astragalus polysaccharides, astragalus saponins, astragalus total flavonoids, Polygonatum polysaccharides, Polygonatum saponins, Ganoderma lucidum polysaccharides, Ganoderma lucidum triterpenoids: Ningbo Dekang Biolo...

Embodiment 2

[0158] Example 2 Screening of astragalus polysaccharides, ganoderma polysaccharides and ganoderma triterpenes on chemotherapy synergies based on factorial design

[0159] 1 Materials and methods

[0160] 1.1 Experimental materials

[0161] 1.1.1 Main Instruments

[0162] Same as Experiment 1

[0163] 1.1.2 Experimental drugs

[0164] Astragalus polysaccharide, Ganoderma lucidum polysaccharide, Ganoderma lucidum triterpenes: Ningbo Dekang Biological Products Co., Ltd.

[0165]Cisplatin (DDP): Jiangsu Hansoh Pharmaceutical Co., Ltd. 30mg / bottle (Guoyao Zhunzi H20040813, batch number: 120703)

[0166] 1.1.3 Cell lines and experimental animals

[0167] Lewis lung cancer cell line (3LL): Provided by the Basic Laboratory of Tumor Research Institute, Chest Hospital Affiliated to Shanghai Jiao Tong University. Use RPMI1640 cell culture medium (100μg / mL penicillin, 100μg / mL streptomycin, 10% fetal bovine serum) at 37°C CO 2 Constant temperature incubator, 0.25% trypsin digestion...

Embodiment 3

[0219] Example 3 Experimental Research on the Optimal Proportion of Astragalus Polysaccharide and Ganoderma Lucidum Polysaccharide on Chemotherapy Synergistic Effect

[0220] 1 Materials and methods

[0221] 1.1 Experimental materials

[0222] 1.1.1 Main Instruments

[0223] Ultra-clean workbench: American Baker Company

[0224] KA-1000 centrifuge: Shanghai Feige Instrument Co., Ltd.

[0225] HH·W21·600S electric constant temperature water tank: Shanghai Yuejin Medical Devices Co., Ltd.

[0226] Electronic balance: American Ohaus Company

[0227] 10-100μL pipette: Eppendorf, Germany

[0228] Various types of cell culture bottles, petri dishes, cryotubes, pipettes, pipette tips: American Corning Corporation

[0229] 1.1.2 Experimental drugs

[0230] Astragalus polysaccharide: Ningbo Dekang Biological Products Co., Ltd. (batch number: 201214135)

[0231] Ganoderma lucidum polysaccharide: Ningbo Dekang Biological Products Co., Ltd. (batch number: 201214130)

[0232] Cispla...

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Abstract

The invention discloses a Chinese medicine effective component composition and an application thereof, and provides an application of astragalus polysaccharide and ganoderan to preparing a medicine for preventing or treating tumors and preparing a medicine composition for assisting radiotherapy and chemotherapy. The mass ratio of the astragalus polysaccharide to the ganoderan is 10:3-3:10. By performing experimental research on additive chemotherapeutic effects of effective components of a qi and essence replenishing small prescription 'astragalus, sealwort and ganoderma', effective component compatibility and ratio with a certain safety, effectiveness and specific major functions are researched and developed. The Chinese medicine effective component composition can be effectively applied to preparing the medicine for preventing or treating the tumors particularly liver cancer and assisting radiotherapy and chemotherapy, accurate and effective clinical medicine dosage is ensured, curative effects are improved, medicinal materials are saved, toxic and side effects are decreased, and a modern novel Chinese medicine with clear components and explicit principle can be created.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine active component composition and its application. Background technique [0002] Malignant tumors seriously threaten human life and health, and are the diseases with the highest mortality rate in the world. With the change of people's lifestyle and the aggravation of environmental pollution, its incidence has been increasing year by year in recent years. Modern medicine lacks effective means for the treatment of malignant tumors, especially for advanced unresectable tumors, the treatment methods are limited to chemotherapy, radiotherapy, immunization, etc., and the effective rate and patient benefit rate are unsatisfactory. With a large number of clinical studies confirming the definite curative effect of traditional Chinese medicine in the treatment of lung cancer, basic research continues to reveal its mechanism of action, and the status of traditional Chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/074A61P35/00
Inventor 徐振晔郭毅峻邓海滨王中奇金长娟赵晓珍王立芳吴继
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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