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A technology of honokiol and magnolia, which is applied in the field of biomedicine, can solve the problems of high cost and long production cycle, and achieve the effect of low production cost and short production cycle
Inactive Publication Date: 2011-05-25
李文东
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Although this type of extraction method can also extract and separate magnolol and honokiol from magnolia bark through the later separation treatment, it requires two extractions, long production cycle and high cost
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[0022] a, get 300 kilograms of fresh Magnolia officinalis (honokiol content is 8%), wash with clear water, dry in the air, chop, put in the leaching tank;
[0023] b. Add 1.5-1.8 tons of clear water to the tank, extract at 30-50°C for 1-2 hours, and filter out the water extract for later use;
[0024] c. Add 1.8-2.4 tons of 70% ethanol (weight content, the same below) to the tank again, heat and boil for 1-2 hours, and filter out the ethanol extract for subsequent use; then add 1.8-2.4 tons of 70% ethanol to the residue in the tank % ethanol, heated and boiled for 1-2 hours, filtered out the secondary ethanol extract for subsequent use; combined the primary ethanol extract and the secondary ethanol extract to obtain the ethanol extract for subsequent use;
[0025] d. Combine the standby water extract in step b and the standby ethanol extract in step c, then heat and concentrate at 60-70°C, recycle ethanol, and obtain 300 liters of concentrated extract for use;
[0026] e, add...
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Abstract
The invention discloses a method for refining honokiol, which relates to the technical field of biomedicine. The honokiol is prepared by the following steps of material preparation, water extraction, ethanol extraction, concentration, precipitation, dissolution, absorption separation, elution, concentration, precipitation, silica gel column chromatography, gradient elution, concentration, drying,crude product obtaining, n-hexane extraction, concentration, cooling and devitrification. The method has the characteristics of short production cycle and low cost, capability of extracting and purifying the honokiol in cortex magnoliae officinalis at one time and the like, can replace the conventional two-step extraction method, and is used for extracting the honokiol from the cortex magnoliae officinalis.
Description
technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for refining honokiol capable of extracting honokiol from magnolia bark at one time. Background technique [0002] Magnolol contains Magnolol, Isomagnolol, Honokiol, Tetrahydromagnolol, and Magnal-dehyde B, C, D, E, Magnolignan (Magnol ignan) A, B, C, D, E, F, G, H, I, Syringaresinol (Syringaresinol), etc., especially honokiol has the strongest biological activity, The most versatile. Honokiol extracted from Magnolia officinalis is brown to white fine powder with aroma, pungent taste and slightly bitter taste. The monomer is a colorless scaly crystal with a melting point of 87.5°C. Benzene, ether, chloroform, ethanol, etc., are insoluble in water; clinically, it is mainly used as a medicine for eliminating chest and abdomen fullness, calming the central nervous system, muscle relaxation for athletes, antifungal, and antiulcer. In the prior art, the extraction of a...
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