Composition for preventing renal calculi

A composition and technology of kidney stones, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of high recurrence rate

Inactive Publication Date: 2012-12-19
NO 3 PEOPLE HOSPITAL AFFILIATED TO SHANGHAI JIAOTOG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Urinary tract calculus is a frequently-occurring disease with a high recurrence rate. At present, there is no once-and-for-all preventive method

Method used

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  • Composition for preventing renal calculi
  • Composition for preventing renal calculi
  • Composition for preventing renal calculi

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0079] Material

[0080] Soybean isoflavone powder: purchased from North China Pharmaceutical Co., Ltd., content 80%, including daidzin 45.9%, genistin 13.36%, daidzein 20.99%, daidzein 0.96%, dye Genistein 0.02%, Glycitein 0.05%. Before use, deionized water was used to make soybean isoflavone suspensions with different concentrations.

[0081] Animal grouping and drug administration method

[0082] Select 50 healthy and clean adult male Wistar rats provided by Shanghai Slack Experimental Animal Co., Ltd. (SLAC), weighing 180-220g, and randomly divide them into 5 groups with 10 rats in each group, and feed them adaptively for 1 week in the same environment. , followed by 4 weeks of treatment as follows:

[0083] Group A (blank control group): drink deionized water;

[0084] Group B (simple lure stone group): 1% ethylene glycol solution as the only source of drinking water;

[0085] Group C-E (Yushi + soybean isoflavone intervention group): 1% ethylene glycol solution was ...

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PUM

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Abstract

The invention discloses a composition for preventing kidney stone, comprising the following components in parts by weight: 10-70 parts of daidzin, 3-25 parts of genistin, 5-35 parts of glycitin, 0.1-2 parts of daidzein, 0.005-0.05 part of genistein and 0.01-0.1 part of glycitein. The total amount of the components accounts for above 80w / w% of the total weight of the composition.

Description

technical field [0001] The invention relates to the field of medicine and food for preventive health care, in particular to a composition for preventing kidney stones. Background technique [0002] The formation mechanism of calcium oxalate stones is complex. Supersaturation of calcium oxalate concentration in urine facilitates the crystal nucleation and growth process. However, after the formation of a single calcium oxalate crystal, it must adhere to the surface of the renal tubular epithelial cells or quickly aggregate to form larger crystals to block the renal tubules; otherwise, it will be quickly washed away by the urine, and kidney stones will not occur ( Atmani F, Slimani Y, Mimouni M, et al. Effect of aqueous extract from Herniaria hirsuta L. on experimentally nephrolithiasic rats [J]. J Ethnopharmacol, 2004, 95(1): 87-93). Since the components in the urine of normal people and patients with calcium oxalate are in a state of supersaturation for the formation of ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/7048A61P13/04A61P13/12
Inventor 张士青
Owner NO 3 PEOPLE HOSPITAL AFFILIATED TO SHANGHAI JIAOTOG UNIV SCHOOL OF MEDICINE
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