4', 5-dyhydroxyl-7-(4-(N, N-diethylamino group) butoxy) isoflavone, preparation method and application of 4', 5-dyhydroxyl-7-(4-(N, N-diethylamino group) butoxy) isoflavone

Abstract

The invention discloses 4', 5-dyhydroxyl-7-(4-(N, N-diethylamino group) butoxy) isoflavone of dye lignin derivative, a preparation method and an application of the 4', 5-dyhydroxyl-7-(4-(N, N-diethylamino group) butoxy) isoflavone. The 4', 5-dyhydroxyl-7-(4-(N, N-diethylamino group) butoxy) isoflavone obtained by chemically modifying the dye lignin derivative has the acetylcholinesterase inhibition activity, the estrogen activity and the nerve cell protective action; and the 4', 5-dyhydroxyl-7-(4-(N, N-diethylamino group) butoxy) isoflavone which is taken as a multi-function target spot can be used for preparing the alzheimer disease-resistant medicament.

Description

technical field

[0001] The invention relates to a genistein derivative and its preparation method and application, in particular to 4',5-dihydroxy-7-[4-(N,N-diethylamino)butoxy]isoflavone And its preparation method and application. Background technique

[0002] Alzheimer's disease is a common senile brain neurodegenerative disease with a high incidence, and has become one of the diseases that seriously threaten the life and health of the elderly in modern society. Typical pathological changes of the disease include β Amyloid deposits form senile plaques, neurofibrillary tangles, basal forebrain cholinergic dysfunction and extensive neuronal loss and altered synaptic morphology in the cortex and hippocampus (see: Roberson ED, Mucke L. 100 years and counting: prospects for defeating Alzheimer's disease. Science 2006;314(5800):781-4).

[0003] The study found that the lesions of the cortex and hippocampus in patients with Alzheimer's disease were more obvious, and the cholin...