Flavonoid compound for preventing and treating diabetes and medicament application thereof

A technology for diabetes and drugs, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Active Publication Date: 2011-08-17
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Litchi herb contains high psyllogenin (Homoplantaginin), high psyllidin (Hispidulin) and other compounds. It has been reported in the literature that high psyllogenin and high psyllogen have antioxidant and hepatoprotective activities. There is no report on the effects of lowering blood sugar, lowering blood fat, and resisting the reduction of NO production in vascular endothelial cells caused by free fatty acids, thereby improving insulin resistance and protecting vascular endothelial cells caused by free fatty acids.

Method used

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  • Flavonoid compound for preventing and treating diabetes and medicament application thereof
  • Flavonoid compound for preventing and treating diabetes and medicament application thereof
  • Flavonoid compound for preventing and treating diabetes and medicament application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1. Preparation of homo-psyllogen and homo-psyllogen :

[0050] Take 10kg of dry Litchi herb, crush it, and extract it with 10 times the amount of 85% ethanol under reflux for 3 times, combine the extracts, concentrate under reduced pressure, and extract the concentrated solution with 4 times the amount of petroleum ether and ethyl acetate for 4 times , after concentrating the ethyl acetate extract under reduced pressure, through silica gel column chromatography several times, eluting with chloroform: methanol (100: 2), collecting the eluate, concentrating, and recrystallizing to obtain high psyllium, yield It was 0.08‰; eluted with chloroform:methanol (100:8) to obtain homopsyllogenin with a yield of 0.29‰.

Embodiment 2

[0051] Embodiment 2: Preparation of homo-psyllogen and homo-psyllogen :

[0052]Take 10kg of dry Litchi herb, crush it, and extract it with 12 times the amount of 80% ethanol under reflux for 3 times, combine the extracts, concentrate under reduced pressure, and extract the concentrated solution with 5 times the amount of petroleum ether and ethyl acetate for 4 times , after concentrating the ethyl acetate extract under reduced pressure, through silica gel column chromatography several times, eluting with chloroform: acetone (100:5) to obtain homopsyllogenin with a yield of 0.09‰; with chloroform: acetone (100 : 15) was eluted, the eluate was collected, concentrated, and recrystallized to obtain homopsyllogenin with a yield of 0.34‰.

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PUM

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Abstract

The invention belongs to the technical field of pharmacy. The invention discloses a flavonoid compound for preventing and treating the diabetes and medicament application thereof, wherein the flavonoid compound is homoplantagin and hispidulin and is separated from the whole Salvia plebeia R. Br. The homoplantagin and the hispidulin can be used for obviously reducing the blood sugar of the mouse which suffer from the alloxan diabetes, reducing the serum total cholesterol content and the triglyceride content, obviously reducing the generation of the nitrogen oxide in the endothelial cell caused by free fatty acid, improving the insulin resistance caused by the free fatty acid, and protecting the endothelial cell of the blood vessel. Therefore, the homoplantagin and the hispidulin have good functions for reducing the blood sugar and the blood fat, and protecting the endothelial cell of the blood vessel, and can be used for preparing the medicament for preventing and curing the diabetes and the cardiovascular disease such as the lipid metabolism dysfunction, the atherosclerosis, the coronary disease and the like caused by the diabetes.

Description

1. Technical field [0001] The invention belongs to the technical field of pharmacy, relates to the preparation method of the flavonoid compound homopsyllogen and its aglycone homopsyllogen, and relates to the prevention and treatment of diabetes, diabetes-induced lipid metabolism disorder and arterial Applications in cardiovascular diseases such as atherosclerosis and coronary heart disease. 2. Background technology [0002] Diabetes mellitus is a group of metabolic abnormal syndromes caused by the interaction of genetic and environmental factors, characterized by hyperglycemia, metabolic disorders, and closely related to insulin secretion. Diabetes can be divided into insulin-dependent diabetes mellitus (Insulin Dependent Diabetes Mellitus, IDDM is also called type 1) and non-insulin-dependent diabetes mellitus (Noinsulin Dependent Diabetes Mellitus, NIDDM is also called type II), the latter accounts for about 95%-99% of the total number of patients %. The main harm of di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61P3/10A61P9/10
Inventor 吴斐华梁敬钰王辉李伟光
Owner CHINA PHARM UNIV
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