3-nitro-2h-chromene compounds with antibacterial activity and preparation method and application thereof

The technology of a compound and a nitro group is applied in the field of 3-nitro-2H-chromene compound and its preparation, which can solve the problems of prolonging the treatment time of patients, increasing the mortality rate and the like, and achieving the effect of simple reaction steps.
CN102153533AInactive Publication Date: 2011-08-17SUN YAT SEN UNIV
0 Cites 7 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2011-08-17
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses 3-nitro-2H-chromene compounds, a preparation method and application thereof. The 3-nitro-2H-chromene compounds have a novel antimicrobial parent nucleus structure, are prepared by reacting salicylaldehyde or substituted salicylaldehyde, n-Bu2NH, phthalic anhydride and 2-nitroethanol, and can be used for preparing medicaments for treating infectious diseases, particularly can be used for preparing medicaments for treating infectious diseases caused by multidrug-resistant bacteria.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to a 3-nitro-2H-chromene compound with antibacterial activity, a preparation method and application thereof. Background technique

[0002] Antibiotics, sulfonamides, and quinolones are used to treat bacterial infectious diseases, but with the widespread use of these drugs, bacteria have developed resistance to these drugs, and even multidrug resistance. For example, methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE), drug-resistant Streptococcus pneumoniae, vancomycin-resistant Enterococcus (VRE) and Staphylococcus aureus (VRSA), etc. The emergence and spread of these drug-resistant bacteria has brought serious problems to the treatment of bacterial infectious diseases, resulting in prolonged treatment time and increased mortality for patients. Therefore, it is of great significance to develop new structures and drugs with non-traditional ant...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More