Preparation method for chiral dendrimers/gold nanoparticles modified by mPEG
A technology of dendrimer and gold nanoparticles, which is applied to preparations and pharmaceutical formulations for in vivo experiments, to achieve the effects of controllable size, simple method and high X-ray attenuation intensity
Inactive Publication Date: 2011-08-17
DONGHUA UNIV
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The invention relates to a preparation method for chiral dendrimers/gold nanoparticles modified by mPEG (Methoxy Polyethylene Glycol), comprising the steps of: (1) modifying the chiral dendrimers by using mPEG-MAL (Maleimide) and dialyzing, freezing and drying to obtain solids; (2) dissolving the solids with methanol or water, and adding a chloroauric acid solution and then a NaBH4 solution after mixing, reacting at a room temperature; and then adding triethylamine and acetic anhydride, dialyzing a reaction product after the reaction is ended and freezing to obtain a final product by. The invention has the advantages of increasing molar ratio of the gold to the chiral dendrimers and reducing cost of materials, and at the same time enhancing stability of the gold nanoparticles and being successfully applied in the mice's in-vivo imaging; and the method has the advantages of simpleness, mild reaction conditions and easy operation, and has the prospect for the implementation of industrialization.
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