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The treatment of hearing loss

A technology for hearing loss and adenosine receptors, which is used in medical preparations containing active ingredients, respiratory diseases, organic active ingredients, etc.

Inactive Publication Date: 2011-08-17
AUCKLAND UNISERVICES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although local delivery of compounds to the RWM is common in clinical practice, it is a surgical procedure and has some other disadvantages

Method used

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  • The treatment of hearing loss
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Embodiment Construction

[0071] The present invention generally relates to A 1 Use of adenosine receptor agonists in the treatment of hearing loss.

[0072] In a particularly preferred embodiment, the invention relates to A 1 Use of an adenosine receptor agonist in the preparation of a medicament for treating noise-induced hearing loss.

[0073] Adenosine receptors are present in most body tissues, including the cochlea of ​​the inner ear. Adenosine plays a role in tissue protection and recovery from stress. The inventors found that using A1 Adenosine receptor agonists effectively restore hearing sensitivity to noise-induced cochlear damage. I used to think that A 1 Adenosine receptor agonists are for preventive use only. Due to this idea, A 1 Adenosine receptor agonists have been considered to have limited practical application.

[0074] In a preferred aspect, using A 1 Adenosine receptor agonists can provide hearing recovery of about 5-12 dB, or more preferably about 25-30 dB, or about 30-60...

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PUM

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Abstract

The invention provides a method of treating noise-induced hearing loss, the method including the step of administering an A1 adenosine receptor agonist to a patient in need thereof. In a particularly preferred embodiment the A1 adenosine receptor agonist is a selective A1 adenosine receptor agonist.

Description

technical field [0001] The present invention generally relates to 1 A method of administering an adenosine receptor agonist to a patient in need thereof to treat noise-induced hearing loss. Background technique [0002] Hearing impairment is a serious health and social problem. One of the most common causes of hearing loss is overexposure to noise. This problem is especially prevalent in the military and in industrial settings (construction workers, mining, forestry and aerospace) where conventional hearing protection procedures are difficult to implement. Some leisure activities (shooting, listening to loud music) can also cause unintended hearing loss. U.S. health statistics show that hearing loss affects more than 25 million Americans and costs $50 billion a year, which is more than the combined economic costs of multiple sclerosis, stroke, epilepsy, spinal injuries, Huntington's disease, and Parkinson's disease Influence [1]. It is estimated that 10-13% of New Zeala...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4188A61K31/7076
CPCA61K31/00A61K31/7076A61P11/02A61P27/16
Inventor S·维拉杰科维克P·R·索恩G·D·豪斯利
Owner AUCKLAND UNISERVICES LTD
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