Negundo chastetree fruit extract and application thereof

Abstract

The invention relates to the technical field of medicine. Rheumatoid arthritis (RA) is one of the most important diseases which are harmful to human health at present, and the formidable task and problem to be solved in the global medicine world is to seek high-efficiency and low-toxicity medicaments for preventing and treating the RA. The invention provides negundo chastetree fruit extract. A method for preparing the negundo chastetree fruit extract comprises the following steps of: performing hot extraction on negundo chastetree fruit by using hydrous ethanol, concentrating extracting solution, loading to macroporous adsorbent resin, eluting by using the hydrous ethanol, concentrating eluent and drying to obtain the negundo chastetree fruit extract. Pharmacodynamic study indicates that the negundo chastetree fruit extract can be used for preparing medicaments or food for resisting the rheumatoid arthritis. The negundo chastetree fruit extract is a new source for seeking the medicaments for resisting the rheumatoid arthritis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the extract of Vitex vetex and its application in medicine or food for preventing or treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is one of the most important diseases that endanger human health at present, and is called "the cancer that never dies". RA is a chronic systemic autoimmune inflammatory disease characterized by multi-joint involvement, synovial inflammation, and bone and cartilage destruction. Its pathogenesis has not yet been fully elucidated. Disorders are closely related (Imboden JB. The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol Mech Dis 2009.4: 417-434.). The prevalence of RA in my country is about 0.3%-0.4%, and there are about 4 million patients. The disability rate is 60% within 5-10 years of the disease course, and 90% of patients in the late stage lose their social labor force and self-care ability...

AI Technical Summary

Problems solved by technology

At present, most of the pharmacological studies on Vitex negundo focus on analgesia (Zheng CJ, Tang WZ, Huang BK, Han T, Zhang QY, Zhang H, Qin LP. Bioactivity-guided fractionation for analgesic properties and constituents of Vitex negundo L. seeds . Phytomedicine 2009, 16: 560-567.), anti-oxidation (Zheng Gongming, Luo Zongming, Chen Damei. Research on Antioxidant Components of Vitex Vitex Seed. Journal of Guangdong University of Technology, 1999, 16(2): 41-46.), Regulating Hormone Levels (Bhargava SK, et al. Antifertility effects of the flavonoids (VI-VII) of Vitex negundo L. seeds in dogs. Plant Med Phytother, 1986, 20 (2): 188-198.), anti-tumor (Zhou Y, Liu YE, Cao J, Zeng G, Shen C, Li Y, Zhou M, Chen Y, Pu W, Potters L, Shi YE. Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res 2009, 15 (16): 5161-5169.), liver protection (Avadhoot Y, Rana AC. Hepatoprotective effect of Vitex negundo agamst carbon tetrachloride-induced liver damage. Arch Phar Res 1991, 14(1): 96-98.) and other biological activities , but so far there is no report about the use of Vitex chrysanthemum and its extracts in anti-rheumatoid arthritis

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