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Application of echinacoside in preparation of medicine for treating inflammatory bowel disease

A technology for inflammatory bowel disease and echinacoside, which is used in the preparation of medicines for the treatment of inflammatory bowel disease, the field of echinacoside

Inactive Publication Date: 2011-12-21
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of action of echinacoside on inflammatory bowel disease has not been reported yet. In this study, 3% DSS was used to induce the mouse model of ulcerative colitis, and it was found that echinacoside could reduce the effect of dextran sodium sulfate (DSS). The damage of intestinal tissue structure can reduce the symptoms of inflammatory bowel disease and promote the repair of damaged parts, suggesting that echinacoside has a new pharmacological activity, which can be used to treat and prevent inflammatory bowel disease

Method used

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  • Application of echinacoside in preparation of medicine for treating inflammatory bowel disease
  • Application of echinacoside in preparation of medicine for treating inflammatory bowel disease
  • Application of echinacoside in preparation of medicine for treating inflammatory bowel disease

Examples

Experimental program
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Effect test

Embodiment 1

[0024] This example proves that echinacoside has a significant alleviating effect on 3% DSS-induced ulcerative enteritis model mice through animal experiments, can relieve the symptoms of inflammatory bowel disease, promote the repair of damaged parts, and protect intestinal tissue, etc. pharmacological activity.

[0025] Echinacoside standard substance (purchased from China Institute for the Control of Pharmaceutical and Biological Products, purity ≥ 95%). Dextran Sulfate Sodium DSS (Dextran Sulfate Sodium: DSS, molecular weight 6000, purchased from Sigma Company).

[0026] The experimental steps and results are as follows:

[0027] (1) Animal experiments

[0028] Male C57BL / 6 mice weighing 20-25 g were selected and randomly divided into 3 groups with 8 mice in each group. Set only feeding 3% DSS (dextran sodium sulfate) group as the acute ulcerative enteritis model control group, feeding 3% DSS+120ug / ml echinacoside as the experimental treatment group, normal drinking wat...

Embodiment 2

[0042] Medicinal ingredients: 1 g of echinacoside, 100 g of calcium sulfate, 50 g of cellulose, 5 g of silica gel, and 1.5 g of sodium stearate.

[0043] Preparation method: take the raw materials and pass through a 100-mesh sieve; take echinacoside, calcium sulfate, and cellulose, mix them evenly, use an appropriate amount of 60% ethanol as a binder to make a soft material, pass through a 20-mesh sieve to make granules, and dry at 60°C. Take it out, pass through a 30-mesh sieve for granulation, add silica gel and sodium stearate, mix well, and tablet to make 1000 tablets.

Embodiment 3

[0045] Medicinal ingredients: echinacoside 10g, calcium sulfate 100g, cellulose 50g, silica gel 5g, sodium stearate 1.5g.

[0046] Preparation method: take the raw materials and pass through a 100-mesh sieve; take echinacoside, calcium sulfate, and cellulose, mix them evenly, use an appropriate amount of 60% ethanol as a binder to make a soft material, pass through a 20-mesh sieve to make granules, and dry at 60°C. Take it out, pass through a 30-mesh sieve for granulation, add silica gel and sodium stearate, mix well, and tablet to make 1000 tablets.

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PUM

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Abstract

The invention discloses the application of echinacoside in the preparation of medicaments for treating inflammatory bowel disease, which belongs to the technical field of treating gastrointestinal diseases. The pharmaceutical preparation with echinacoside as the active ingredient can reduce the damage of 3% DSS to the intestinal tract, help protect the tissue structure of the intestinal tract, reduce the infiltration of inflammatory cells, and increase the proportion of proliferating cells in the epidermis and muscle layer. The present invention also clarifies the mechanism of action of echinacoside on inflammatory bowel disease: echinacoside can resist inflammation, promote the repair of damaged tissue and maintain the internal environment of the inflammatory site, relieve loose stools and bloody stools, and promote the recovery of damaged tissues. Proliferation of intestinal muscular epithelial cells and reduced inflammatory infiltration.

Description

technical field [0001] The invention belongs to the technical field of treating gastrointestinal diseases, and in particular relates to the application of echinacoside in the preparation of medicines for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease is a common gastrointestinal disease and one of the main factors inducing colorectal cancer. Patients are often accompanied by symptoms such as abdominal pain and bloody stools. The etiology is complex and often repeated and difficult to cure completely. The longer the history of inflammatory bowel disease, the greater the probability of inducing colorectal cancer. According to statistics, patients with a history of 10 years have a 2% risk, 8% in 20 years, and 18% in 30 years. colorectal cancer. [0003] Clinically, highly effective immunosuppressants are often used to treat inflammatory bowel disease, such as aminosalicylate, 5-aminosalicylic acid, balsalazide sodium, olsalazide s...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P1/00A61P29/00
Inventor 郭玉海贾亚敏杜才干朱艳霞
Owner CHINA AGRI UNIV
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