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A kind of crocetin injection and preparation method thereof

A technology of crocetin and injection, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc. It can solve the problems of affecting the use, poor water solubility of crocetin, and the treatment can not achieve the expected effect, so as to achieve the effect of ensuring safety

Inactive Publication Date: 2011-12-28
广东省中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, crocetin has poor water solubility and is difficult to absorb when taken orally. Therefore, the material can not achieve the expected effect in the treatment of diseases with oral preparations, which affects the clinical application. This is an urgent technical problem to be solved in the development of crocetin.

Method used

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  • A kind of crocetin injection and preparation method thereof
  • A kind of crocetin injection and preparation method thereof
  • A kind of crocetin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Preparation of Crocetin Injection

[0059] prescription:

[0060]

[0061] Preparation method: Take the prescribed amount of crocetin raw material, add 500ml of propylene glycol, 200ml of PEG600, heat to 60°C and stir until the saffron acid raw material is fully dissolved, then add 300ml of water for injection, stir evenly, add 2g of activated carbon, stir at 80°C for 15 minutes, filter , filling, sterilizing, light inspection, and packaging to obtain the crocetin injection with a specification of 1ml:20mg.

Embodiment 2

[0063] Preparation of Crocetin Injection

[0064] prescription:

[0065]

[0066]

[0067] Preparation method: Take the prescribed amount of crocetin raw material, add 100ml of ethanol, 500ml of propylene glycol, and 100ml of PEG400, heat to 60°C and stir until the crocetin raw material is fully dissolved, then add 300ml of water for injection, stir evenly, add 2g of activated carbon, stir and keep warm at 80°C for 15 minutes, filter, fill, sterilize, light check, pack, and get the crocetin injection with a specification of 1ml:20mg.

Embodiment 3

[0069] Preparation of Crocetin Injection

[0070] prescription:

[0071]

[0072] Preparation method: Take the prescribed amount of crocetin raw material, add 10ml of Tween, 300ml of propylene glycol, 100ml of PEG200 and heat to 60°C and stir until the saffron acid raw material is fully dissolved, then add 590ml of water for injection, stir evenly, add 1g of activated carbon, stir and keep warm at 80°C After 15 minutes, filter, fill, sterilize, inspect with light, and pack, the crocetin injection with the specification of 2ml:20mg is obtained.

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Abstract

The invention relates to a crocetin injection and a preparation method thereof. The crocetin contains crocetin and auxiliary materials which can help dissolve or regulate osmotic pressure. The weight ratio between the crocetin and the auxiliary materials is 1:10-1:500. The content of the crocetin raw material used in the injection involved in the present invention should be greater than 90%, and other impurities should be less than 10%. The preparation of the invention has good stability, low cost, all indexes meet the requirements of the preparation, and the preparation process has the characteristics of quick dissolution of raw materials and simple process, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a crocetin injection and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Saffron acid has the functions of dredging meridians and activating collaterals, dredging meridians and dissolving stasis, reducing swelling and pain, cooling blood and detoxification, and worrying and depression. Long-term continuous use can comprehensively improve the body's immunity. Not only that, crocetin also has the effects of promoting blood circulation, anti-inflammatory and pain relief, and it also has a calming effect to eliminate nerve discomfort. Crocetin is also a good medicine for gynecology, which can improve diseases such as irregular menstrual blood, and has the effect of nourishing blood. [0003] In addition, crocetin can enhance physical fitness. Crocetin promotes macrophage function, eliminates "garbage" around the cells, enhances the immune function of cells, improv...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/202A61K47/34A61K47/26A61P15/00A61P25/20A61P29/00A61P7/02A61P35/00A61P9/10A61P1/16
Inventor 张现涛马舒伟王磊何盛江于江月曾庆前
Owner 广东省中药研究所
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