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Extract of rust-coloured crotalaria herb with root for treating epicophosis and tinnitus, and preparation method and application thereof

A technology of bellflower extract, deafness and tinnitus, applied in the field of bellflower extract, can solve the problems of not satisfying clinical patients, not forming, etc., and achieve the effect of preventing hearing loss in animals

Inactive Publication Date: 2012-02-01
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few Chinese and Western medicines for the treatment of deafness, and few new medicines are on the market, which cannot meet the needs of clinical patients. Therefore, the development of deafness and tinnitus medicines is realistic and forward-looking. After the products are put on the market, significant economic and social benefits can be obtained
Bell grass nourishes the liver and nourishes the kidneys, etc. It has been widely used in the folk to treat deafness and tinnitus caused by various reasons, as well as to treat poisonous and malignant sores. It has a history of hundreds of years. Preliminary statistics show that as many as 50% of the reported unilateral prescriptions for the treatment of deafness and tinnitus contain Bellflower, and most of them are treated with a single drug, Bellflower, but most of them are taken as decoction, which is not easy to take. , effective and competitive products

Method used

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  • Extract of rust-coloured crotalaria herb with root for treating epicophosis and tinnitus, and preparation method and application thereof
  • Extract of rust-coloured crotalaria herb with root for treating epicophosis and tinnitus, and preparation method and application thereof
  • Extract of rust-coloured crotalaria herb with root for treating epicophosis and tinnitus, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Preparation of Bellflower Extract

[0015] Dry and pulverize the bellflower through a 10-mesh sieve, weigh 10 g of the dried bellflower in each portion, add a certain amount of extraction solvent, and perform ultrasonic pretreatment. Ultrasonic treatment conditions are: frequency 20KHz ~ 25KHz, power 100W, each time 10s, interval 10s, total time of ultrasonic output 20 minutes.

[0016] After ultrasonic treatment, warm immersion extraction was carried out with a certain volume concentration of ethanol as a solvent. Taking ethanol concentration, solid-liquid ratio, extraction temperature, extraction time, and extraction times as the investigation factors, a single factor experiment was done. According to the single factor test results, three factors of ethanol concentration, extraction time, and extraction temperature were selected, and L 9 (3 4 ) to optimize the extraction conditions of total flavonoids from Bellflower.

[0017] Select ethanol concentrat...

Embodiment 2

[0046] Example 2 Investigation of the Pharmacological Effects of Bellflower Extract on Deafness

[0047] The bellflower extract was prepared according to the preferred method of Example 1; 110 3-month-old guinea pigs with normal auricle reflex were selected, half male and half male. They were randomly divided into normal saline control group, gentamicin sulfate deafness model group, Erling Zuoci Pills positive drug control group, bellflower extract high-dose group and low-dose group, with 10 guinea pigs in each group. Except the normal control group of normal saline, the guinea pigs of all other groups were intramuscularly injected gentamicin sulfate 80mg / kg / day to make models every day, and the normal saline control group guinea pigs were injected intramuscularly with the same volume of normal saline every day (each group of rats Food and water intake ad libitum) for 40 consecutive days. After 10 days of modeling, the bellflower extract group was fed with 1ml / 100gBw of me...

Embodiment 3

[0064] Example 3 Clinical Investigation of the Pharmacological Effects of Bellflower Extract on Deafness

[0065] A total of 216 patients were selected, all of whom had unilateral disease, 118 males and 98 females; aged 19 to 68 years; the course of disease was 1 to 7 days, and were divided into mild deafness, moderate deafness, moderate to severe deafness, Severely deaf. 216 cases were randomly divided into two groups, 128 cases in the Zidan Huoxue Tablet group, 8 cases of mild deafness, 52 cases of moderate deafness, 40 cases of moderate and severe deafness, and 28 cases of severe deafness. The control group consisted of 88 cases, including 8 cases of mild deafness, 32 cases of moderate deafness, 44 cases of moderate to severe deafness, and 4 cases of severe deafness.

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PUM

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Abstract

The invention provides an extract of rust-coloured crotalaria herb with root for treating epicophosis and tinnitus, and a preparation method and application thereof. Pharmacological tests prove that the extract of the rust-coloured crotalaria herb with root for treating epicophosis and tinnitus can inhibit hearing loss further caused by gentamycin sulfate, and can prevent an animal hearing loss effect caused after injection of gentamycin; and during clinical application, the effective rate of mild epicophosis is 10 percent, and the effective rate of moderate and heavy epicophosis is greater than 50 percent.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract for treating deafness and tinnitus, and more specifically relates to a bellflower extract for treating deafness and tinnitus, a preparation method and application thereof. technical background [0002] Bellflower is a folk herbal medicine in Guang'an, Sichuan Province. It has a long history of medicinal use. Its nature and flavor are slightly sour and cold. We identified Bellweed as the whole plant or rooted whole plant of the Fabaceae Hyospermum genus. Mainly produced in Yunnan, Sichuan, Guizhou and other places. Bellflower was first recorded in "Southern Yunnan Materia Medica": "Concentrating lung energy, relieving cough, eliminating phlegm, and relieving asthma." ": "invigorating the middle and replenishing qi, treating tinnitus, dizziness, metrorrhagia. Purging fire and clearing heat, calming liver wind, reducing swelling and pain." "Sichuan Traditional Chinese Medicine": "Replenish...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P27/16
Inventor 杨宪唐倩刘筱琴杨宗发杨元娟陈竹曾雪张雪杨水平
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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