Process for preparing Guifudihuang dripping pill

Abstract

The invention relates to a process for preparing a Guifudihuang dripping pill. The Guifudihuang dripping pill comprises the following medicines: 1-2 parts of Cinnamomum cassia, 1-2 parts of Radix Aconiti Lateralis Preparata (processed), 8-16 parts of prepared rehmannia, 4-8 parts of Fructus Corni, 3-6 parts of tree peony bark, 4-8 parts of Chinese yam, 3-6 parts of Indian Buead, and 3-6 parts of oriental waterplantain rhizome. The process of the invention has the following advantages: the taking amount of the dripping pill, which is greatly reduced, is reduced by 50% than the taking amount of original Guifudihuang capsules because all the medicines are extracted with different solvents according to main effective components and physical and chemical properties of each medicine of above composition, and a D101 macroporous adsorption resin column is adopted for separation, purification and impurity removal; and a fat and water soluble matrix which is adopted for dispersion allows the time limit of disintegration and dissolution to be substantially shortened, extracts to be dispersed in the matrix, the absorption to be good, the biological utilization degree to be improved, and the curative effect to be improved. Animal experiments show that the Guifudihuang dripping pill has substantial improvement effects on symptoms of kidney and qi yang deficiency, long-term toxicity tests show that the Guifudihuang dripping pill is safe in clinical applications; and compared with quality control standards of Guifudihuang pills and the Guifudihuang capsules, the quality control standard of the Guifudihuang dripping pill is greatly improved.

Description

Technical field: [0001] The invention belongs to a traditional Chinese medicine prescription, in particular to a process for preparing Guifu Dihuang dripping pills. Background technique: [0002] Guifu Dihuang Pills originated from Jinkuishenqi Pills of medical sage Zhang Zhongjing. It is the ancestral prescription for invigorating the kidney. ~8 parts, 3~6 parts of Moutan cortex, 4~8 parts of yam, 3~6 parts of Poria cocos, 3~6 parts of Alisma. It has the effect of warming and tonifying kidney yang. Insufficient kidney yang, soreness and coldness of the waist and knees, edema of the limbs, difficulty in urinating or excessive urination, dyspnea and cough due to phlegm retention, and quenching thirst. This prescription has been around for nearly two thousand years, and it has been used for a long time due to its definite curative effect. [0003] Deficiency of kidney qi and yang is a natural law of people. With age, the deficiency of kidney qi and yang becomes more and mor...

AI Technical Summary

Problems solved by technology

Not only is the dosage too large, which is difficult for patients to accept, but also the release and absorption rate of active ingredients is extremely low due to the use of crude drugs and honey as pills, which greatly affects the efficacy of the medicine.

In recent years, on the basis of the original prescription of Guifu Dihuang Pills, it has been improved into Guifu Dihuang Capsules, but the dosage is still very large, 7 capsules each time, twice a day. It is impossible for so many capsules to disintegrate immediately when they enter the stomach. Floating in the stomach, many patients will feel bloated and uncomfortable, and the market has been poor