Pharmaceutical composition of imipenem, cilastatin and sulbactam

A technology of imipenem and cilastatin sodium, applied in the field of combined drugs, the combined drug field of imipenem and cilastatin sodium/sulbactam sodium, can solve the problem of multi-drug resistant Acinetobacter baumannii Intrusion, etc.

Active Publication Date: 2013-03-27
深圳麦德凯诺医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Carbapenems are the drug of choice for the treatment of severe Acinetobacter baumannii infections, but carbapenem-multidrug-resistant strains have emerged around the world in recent years, with worrying multi-drug resistance emerging from Spain to Norway The "invasion" phenomenon of Acinetobacter baumannii is prevalent among traumatized soldiers of the U.S. and British troops stationed in Afghanistan and Iraq, causing serious public health problems. Acinetobacter baumannii brought back by the U.S. military in Iraq is prevalent in the United States

Method used

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  • Pharmaceutical composition of imipenem, cilastatin and sulbactam
  • Pharmaceutical composition of imipenem, cilastatin and sulbactam
  • Pharmaceutical composition of imipenem, cilastatin and sulbactam

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Study on antibacterial effect of imipenem cilastatin sodium / sulbactam sodium in vitro

[0033] 1. Test drugs:

[0034] Imipenem, imipenem cilastatin sodium, and sulbactam sodium were purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0035] The following proportions are calculated by weight, wherein the weight of imipenem and imipenem cilastatin sodium is calculated based on the dry conversion of imipenem, and the weight of sulbactam sodium is based on the dry conversion of sulbactam sodium. Bartan calculated.

[0036] 2. Test ratio:

[0037] (1) Imipenem

[0038] (2) Sulbactam Sodium

[0039] (3) Imipenem cilastatin sodium / sulbactam sodium (3:1)

[0040] (4) Imipenem cilastatin sodium / sulbactam sodium (2:1)

[0041] (5) Imipenem cilastatin sodium / sulbactam sodium (1:1)

[0042] (6) Imipenem cilastatin sodium / sulbactam sodium (1:2)

[0043] (7) Imipenem cilastatin sodium / sulbactam sodium (1:4)

[0044...

Embodiment 2

[0076] Example 2: Study on the antibacterial effect of imipenem cilastatin sodium / sulbactam sodium in vivo

[0077] The combined drug of imipenem cilastatin sodium and sulbactam sodium in weight ratio (3:1, 2:1, 1:2, 1:2, 1:4) has a significant effect on infected mice. Antibacterial therapeutic effect.

[0078] 1 Test drug

[0079] Imipenem, imipenem cilastatin sodium, and sulbactam sodium were purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0080] Small white mice, Kunming species, weighing 18-22g, half male and half male. Provided by the Experimental Animal Laboratory of the Second Hospital of China Medical University. Certificate number, Liao Shi Dong Gong Zi 031. Randomly divided into groups, 10 in each group, half male and half male. Set up 7 dose groups, each mouse was intraperitoneally injected with 10 -5 MLD bacteria liquid 0.5ml. Calculation of ED in Bacterial Probability Units 50 (each drug)

[0081] 2 Dru...

Embodiment 3

[0100] Example 3: The combined drug of imipenem and sulbactam sodium in weight ratio (2:1) (1:1), (1:4) has significant antibacterial therapeutic effect on infected mice

[0101] 1. Test drug

[0102] Imipenem, cilastatin sodium and sulbactam sodium were purchased from China Institute for the Control of Pharmaceutical and Biological Products.

[0103] Cefoperazone + sulbactam sodium (1:1), provided by Guangzhou Dinghui Pharmaceutical Technology Development Co., Ltd.

[0104] Small white mice, Kunming species, weighing 18-22g, half male and half male. Provided by the Experimental Animal Laboratory of the Second Hospital of China Medical University. Certificate number, Liao Shi Dong Gong Zi 031. Randomly divided into groups, 10 in each group, half male and half male. Two dosage groups were established, and each mouse was intraperitoneally injected with 10 -5 MLD bacteria liquid 0.5ml. Calculation of ED in Bacterial Probability Units 50 (each drug).

[0105] 2. Drug prepa...

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PUM

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Abstract

The invention provides a combined medicine and specifically provides a combined medicine of imipenem / cilastatin sodium and sulbactam sodium for treating infectious diseases caused by acinetobacter baumanii. The combined medicine of imipenem / cilastatin sodium and sulbactam sodium has a synergistic effect and accumulated antibacterial action on infectious diseases caused by acinetobacter baumanii, especially a good synergistic effect and accumulated antibacterial action on multidrug resistant acinetobacter baumanii stains, and can be used for curing clinical infection caused by multidrug resistant acinetobacter baumanii in clinical practice.

Description

technical field [0001] The invention provides a combination medicine, in particular, a combination medicine of imipenem cilastatin sodium / sulbactam sodium for treating infectious diseases caused by Acinetobacter baumannii. It belongs to the field of medical technology. Background technique [0002] Carbapenem antibiotics are a class of antibiotics with the broadest antibacterial spectrum and strong antibacterial activity so far. In the past 20 years, imipenem and cilastatin sodium among carbapenems have been used as compound preparations. Its components are imipenem 500mg and cilastatin sodium (calculated as C16H25N2O5S) 500mg, which are key drugs for the treatment of severe infections, especially in the treatment of severe infections of the respiratory tract, which have irreplaceable curative effects and have saved the lives of countless patients , but with the widespread use of carbapenems, the resistance rate of Acinetobacter baumannii to carbapenems has increased year b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/43A61K31/407A61K31/198A61P31/04A61P11/00A61P7/00A61P13/00
Inventor 邱初
Owner 深圳麦德凯诺医药科技有限公司
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