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Use of bergenin in preparation of drugs for treatment of diabetes

A diabetes drug, the technology of petracenin, which is applied in the direction of drug combination, metabolic diseases, etc., can solve the problems that there is no petracenin.

Inactive Publication Date: 2012-04-04
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no relevant report that petracenin has the pharmacological activity of preventing insulin resistance and improving insulin sensitivity

Method used

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  • Use of bergenin in preparation of drugs for treatment of diabetes
  • Use of bergenin in preparation of drugs for treatment of diabetes
  • Use of bergenin in preparation of drugs for treatment of diabetes

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0019] 1. Main reagents and experimental animals

[0020] Petgenin was purchased from Shanghai Yansheng Biochemical Reagent Co., Ltd., with a purity of ≥98%. Glucose, TG (triglyceride) and TCHO (total cholesterol) detection kits were purchased from Beijing Zhongsheng Hi-tech Technology Company, immunohistochemical kits were purchased from Beijing Zhongshan Company, high-fat feed (containing 7.5% lard, 7.5% Safflower oil, 1% cholesterol, 1% casein, 10% sucrose, etc.) were purchased from the Experimental Animal Center of the Chinese Academy of Medical Sciences.

[0021] The animals used in the experiment were SPF grade SD rats (male, 120-140 g), which were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal certificate number SCXK (Beijing) 2002-0003. The animals were kept in the SPF experimental animal room of the Institute of Medicinal Botany, Chinese Academy of Medical Sciences, with constant temperature and humidity, and a high-fat diet.

...

Embodiment 1

[0036] The preparation of embodiment 1 oral liquid

[0037] Take an appropriate amount of petogenin, add an appropriate amount of solubilizer, grind, add a small amount of water to dilute, mix evenly, then add flavoring agents and preservatives, mix evenly, add water to the specified amount. Mix well, subpackage, sterilize, and get ready.

Embodiment 2

[0038] The preparation of embodiment 2 tablet

[0039]Take an appropriate amount of petogenin, add an appropriate amount of auxiliary materials, mix well, make granules, dry, and press into tablets to obtain.

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Abstract

The present invention discloses a use of bergenin in preparation of drugs for treatment of diabetes, and belongs to the field of the pharmacological use of the bergenin. The results of animal experiments show that: with the bergenin, the model forming rate of type 2 diabetes rats can be significantly reduced, the occurrence and the development of insulin resistance can be prevented, the insulin resistance degree of the rats can be significantly reduced, and the insulin sensitivity of the type 2 diabetes rats can be effectively improved. In addition, the results provided by the present invention further show that: with the bergenin, the triglyceride content and the total cholesterol content in blood serum can be significantly reduced, and the lipid metabolism disorder of the type 2 diabetes rats can be effectively improved. Therefore, the results show that the bergenin can be used for preparing into the drugs for the treatment of the diabetes and the blood lipid reducing drugs.

Description

technical field [0001] The invention relates to a pharmacological use of petracenin, in particular to the use of petracenin in preparing medicines for treating diabetes, and belongs to the field of pharmacological uses of petracenin. Background technique [0002] Bergenin (bergenin), also known as Bergenin, catechin, saxifrage, Bergenin, bergamot, etc., is the whole herb of Bergenia purpurascens and thick-leaf Bergenia ( B.crassifoloa, Astilbe macroflora), Ardisia crispa and other plant roots, stems and leaves, the molecular formula is C 14 h 16 0 9 , whose structure is shown in figure 1 . [0003] Begenin has a wide range of pharmacological activities. Studies have shown that petracenin has immune enhancement, anti-inflammatory, anti-coagulant, anti-coagulant and anti-arrhythmic effects, expectorant, anti-asthma and cough-relieving effects, liver-protecting effects, anti-secretion, anti-ulcer effects, anti-HIV Virus effect and anti-oxidation effect, etc. (Xia Conglong...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P3/10A61P3/06A61P3/00
Inventor 金文孙虹
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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