The invention belongs to the technical field of
pharmacy. The invention discloses a
flavonoid compound for preventing and treating the diabetes and medicament application thereof, wherein the
flavonoid compound is homoplantagin and hispidulin and is separated from the whole
Salvia plebeia R. Br. The homoplantagin and the hispidulin can be used for obviously reducing the
blood sugar of the mouse which suffer from the
alloxan diabetes, reducing the serum
total cholesterol content and the
triglyceride content, obviously reducing the generation of the
nitrogen oxide in the endothelial
cell caused by free
fatty acid, improving the
insulin resistance caused by the free
fatty acid, and protecting the endothelial
cell of the
blood vessel. Therefore, the homoplantagin and the hispidulin have good functions for reducing the
blood sugar and the blood fat, and protecting the endothelial
cell of the
blood vessel, and can be used for preparing the medicament for preventing and curing the diabetes and the cardiovascular
disease such as the
lipid metabolism dysfunction, the atherosclerosis, the coronary
disease and the like caused by the diabetes.