Method for preparing medium- and long-chain triglyceride by virtue of packed bed reactor

A packed bed reactor, triglyceride technology, applied in chemical instruments and methods, biochemical equipment and methods, enzymes, etc., can solve the problem of repeated recycling of unfavorable enzyme activities, unmentioned recycling of enzyme particles and by-products, reaction Long time and other problems, to achieve the effect of shortening the reaction time, reducing the reaction cost and improving the reaction efficiency

Active Publication Date: 2015-11-25
广东善百年特医食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the reactor used in this method is still a traditional stirred reaction vessel, so only intermittent reactions can be performed, and the enzyme particles need to be directly added to the reaction system, which is not conducive to the maintenance of enzyme activity and the repeated recycling of enzymes, resulting in a longer reaction time. Long (60–180min)
The law does not yet mention the recycling of enzyme granules and by-products

Method used

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  • Method for preparing medium- and long-chain triglyceride by virtue of packed bed reactor
  • Method for preparing medium- and long-chain triglyceride by virtue of packed bed reactor
  • Method for preparing medium- and long-chain triglyceride by virtue of packed bed reactor

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A method for preparing medium and long-chain triglycerides using a packed bed reactor, the method is as Figure 4 shown, including the following steps:

[0034] (1) A certain amount of Novozymes immobilized lipase LipozymeTLIM is filled in a glass reaction column with a heat jacket 7 to make an enzyme packed bed reactor; the schematic diagram of the enzyme packed bed reactor device is as follows image 3 As shown, it includes product tank 1, packed column 2, constant flow pump 3, substrate tank 4, constant temperature thermal bath 5 and thermal bath pump 6, wherein product tank 1, packed column 2, constant current pump 3 and substrate tank 4 Connected sequentially, the constant-temperature thermal bath 5, the thermal bath pump 6 and the thermal jacket 7 are circularly connected.

[0035] (2) Get the mixture of 45.0g caprylic acid glyceride and 55.0g soybean oil as reaction substrate, add in the substrate tank 4.

[0036] (3) Turn on the constant temperature heat bath ...

Embodiment 2

[0047] This implementation example is the same as Example 1 except the following technical characteristics: the reactant used in the step (2) is the mixture of 40.0g caprylic acid glyceride and 60.0g soybean oil; the reaction temperature described in the step (3) is 80 ℃ , the flow rate is 1.4mL / min, and the reaction time is 60min; in step (4), the ethanol with a mass concentration of 85% is used to extract the crude product obtained after the transesterification reaction, and the solid-liquid ratio of the crude product and ethanol is 1:9, After vacuum distillation, the final product is obtained.

[0048] Through the detection and calculation of the method described in Example 1, the content of medium and long-chain triglycerides in the crude product obtained after step (3) transesterification in this example is 68.8%; the final product is obtained after extraction and vacuum distillation, The yield was 82.1%, and the medium and long-chain triglyceride content in the final pro...

Embodiment 3

[0050] This embodiment example is with embodiment 1 except following technical characteristics: used reactant is the mixture of 45.0g caprylic acid glyceride and 55.0g soybean oil in the step (2); The temperature of reaction described in the step (3) is 70 ℃ , the flow rate is 1mL / min, and the reaction time is 30min; in step (4), adopting mass concentration as 75% ethanol solution to extract the crude product obtained after transesterification, the solid-liquid ratio of crude product and ethanol solution is 1:9 , and then obtain the final product after vacuum distillation.

[0051] Through the detection and calculation of the method described in Example 1, the content of medium and long-chain triglycerides in the crude product obtained after step (3) transesterification in this example is 67.0%; the final product is obtained after extraction and vacuum distillation, The yield was 80.4%, and the medium and long-chain triglyceride content in the final product was 75.7%.

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Abstract

The invention discloses a method for preparing medium- and long-chain triglyceride by virtue of a packed bed reactor, and belongs to the technical field of oil deep processing and modification. Medium-chain fatty acid triglyceride and oil undergo transesterification as raw materials to prepare medium- and long-chain triglyceride in the packed bed reactor under the 1,3-specific immobilized enzyme catalyzing transesterification capable of catalyzing transesterification reaction; then a transesterification product is subjected to ethanol extraction to obtain a high-purity medium- and long-chain triglyceride product; a residual product after extraction can be repacked into the reactor to continue participating in preparation of medium- and long-chain triglyceride of the next batch as a raw material. According to the method, time for reaction in the packed bed reactor can be remarkably shortened to 15 to 60 minutes from original 4 hours for stirring reaction for the preparation of the medium- and long-chain triglyceride, and reaction efficiency is improved; the product with medium- and long-chain fatty acid triglyceride content of not lower than 75 percent can be stably prepared by simple transesterification reaction and subsequent ethanol extraction.

Description

technical field [0001] The invention belongs to the technical field of oil deep processing and modification, and in particular relates to a method for preparing medium and long-chain triglycerides using a packed bed reactor. Background technique [0002] Medium- and long-chain triglycerides are structural lipids containing both medium-chain fatty acids (C6–C12) and long-chain fatty acids (C14–C24), the most typical of which are MLM-type structural triglycerides, whose Sn-1 and The Sn-3 position is a medium-chain fatty acid, and the Sn-2 position is a long-chain fatty acid. The proportion of medium- and long-chain fatty acids contained in medium- and long-chain triglycerides is reasonable, and has the advantages of both long-chain triglycerides and medium-chain triglycerides, reducing the potential of natural triglycerides itself or caused by unreasonable intake. It improves the nutritional function of natural oils, can quickly supply energy, provide essential fatty acids, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/64
CPCB01J8/025C12N9/20C12P7/6454C12Y301/01003B01J8/0292
Inventor 汪勇刘蔓蔓滕英来李爱军张宁
Owner 广东善百年特医食品有限公司
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