Xingnaojing solid medicinal composition and preparation method thereof

A technology of Xingnaojing and its composition, which is applied in the field of medicine, can solve the problems of insufficient utilization of active ingredients, increase of toxic substances, large energy consumption, etc., and achieve the effects of improving bioavailability, taking conveniently, and fully extracting

Active Publication Date: 2013-11-20
SHANGHAI JEMINCARE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in this patent invention, the volatile components of gardenia and the water-soluble components of turmeric are not extracted, so that the active ingredients of the prescription medicinal materials are not fully utilized, and the decoction extract of gardenia needs to be concentrated before it can be adsorbed on a macroporous resin column , in addition to the large energy consumption, the liquid medicine is prone to coking when heated for a long time, which will cause the increase of toxic substances

Method used

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  • Xingnaojing solid medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Prescription: gardenia 3000g, turmeric 3000g, artificial musk 750g, borneol 100g

[0048] 1. Take gardenia and turmeric decoction pieces, grind them into coarse powder respectively, mix them and put them into a multi-energy extraction tank, add 8 times the amount of water, and extract the volatile oil. After 4 hours, 9.65 g of volatile oil was collected.

[0049] 2. After the extraction of volatile oil, the medicinal liquid is first filtered and sucked into the storage tank. Add 10 times the amount of water (5 times the amount, 5 times the amount) to the dregs of the medicine, decoct and extract twice, each time for 1.5 hours, and inhale the above-mentioned extract after the initial filtration. In the storage tank, the medicinal liquid is centrifuged by a GQ-105 tubular separator, and after the supernatant is removed from the centrifuged liquid, it is adsorbed on a D4006 macroporous resin (40 mesh) column, and the flow rate is adjusted to 50ml / min (taking a 120*15cm col...

Embodiment 2

[0057] Prescription: gardenia 6000g, turmeric 6000g, artificial musk 1500g, borneol 200g

[0058] 1. Take gardenia and turmeric decoction pieces, grind them into coarse powder respectively, mix them and put them into a multi-energy extraction tank, add 8 times the amount of water, and extract the volatile oil. After 5 hours, 19.02 g of volatile oil was collected.

[0059] 2. After the extraction of volatile oil, the medicinal liquid is first filtered and sucked into the storage tank. Add 9 times the amount of water (5 times, 4 times) to the medicinal residue, and decoct and extract twice, each time for 1.5 hours. The extract is first filtered and sucked into the above-mentioned In the storage tank, the medicinal liquid is centrifuged by a GQ-105 tubular separator, and after the supernatant is removed from the centrifuged liquid, it is adsorbed on a D4006 macroporous resin (60 mesh) column, and the flow rate is adjusted to 100ml / min (taking a 160*18cm column as an example ), w...

Embodiment 3

[0067] Prescription: gardenia 4500g, turmeric 4500g, artificial musk 1125g, borneol 150g

[0068] 1. Take gardenia and turmeric decoction pieces, grind them into coarse powder respectively, mix them and put them into a multi-energy extraction tank, add 8 times the amount of water, and extract the volatile oil. After 6 hours, 14.31 g of volatile oil was collected.

[0069] 2. After the extraction of volatile oil, the medicinal liquid is first filtered and sucked into the storage tank. Add 9 times the amount of water (5 times, 4 times) to the medicinal residue, and decoct and extract twice, each time for 1.5 hours. The extract is first filtered and sucked into the above-mentioned In the storage tank, the medicinal liquid is centrifuged by a GQ-105 tubular separator, and after the supernatant is removed from the centrifuged liquid, it is adsorbed on a D4006 macroporous resin (20 mesh) column, and the flow rate is adjusted to 75ml / min (taking a 145*16cm column as an example ), wh...

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Abstract

The invention discloses a Xingnaojing solid medicinal composition and a preparation method thereof. The invention is characterized in that the preparation method comprises: based on the formula amount of Xingnaojing injection, extracting mixed volatile oil of cape jasmine fruit and turmeric root tuber by a water vapor distillation method, and forming a beta-cyclodextrin inclusion compound by using the mixed volatile oil and borneol respectively; extracting water soluble components of cape jasmine fruit and turmeric root tuber by decoction in water, absorbing by macroporous resin column, eluting, concentrating, freezing and drying to obtain dry extract power; directly adding artificial musk into the dry extract powder; and mixing the cape jasmine fruit and turmeric root tuber dry extract powder, the mixed volatile oil coated compound, the borneol coated compound and the artificial musk, adding common auxiliary materials, and preparing pharmaceutically acceptable Xingnaojing tablets or Xingnaojing capsules.

Description

Technical field: [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition and a preparation method thereof, in particular to a Xingnaojing solid pharmaceutical composition and a preparation method thereof. Background technique: [0002] The prescription of Xinnaojing is selected from the representative of the traditional Chinese medical prescription - "Angong Niuhuang Powder", the prescription quantity: musk 7.5g, turmeric 30g, gardenia 30g, borneol 1g, in the prescription , musk is pungent and warm, resuscitating and refreshing, can clear up the disadvantages of various orifices, and open the stagnation of meridians; gardenia is bitter and cold, clears away heat and fire, cools blood and detoxifies, and can help musk invigorate blood and cool blood; The main medicine can open all orifices and disperse stagnant fire; turmeric is hard and cold, relieves pungent and bitterness, promotes qi and relieves stagnation, and works with borneo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P25/00A61K31/045A61K31/125A61K35/55
Inventor 胥宝林樊俊红孙克周福康
Owner SHANGHAI JEMINCARE PHARMA CO LTD
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