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A preparation method of Xingnaojing quick-release buccal tablet

A technology of Xingnaojing and immediate release, applied in the field of medicine, can solve the problems of inconvenient use for patients, high market price, discomfort and consolidate treatment drugs, etc., and achieve the effects of solving stability problems, fast drug dissolution, and difficulty in drug resistance.

Active Publication Date: 2015-12-02
WUXI JIYU SHANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an injection, due to the high market price, it is only suitable for clinical emergency medicine, not suitable for consolidation therapy in the recovery period, and it is also inconvenient for patients to use at home.

Method used

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  • A preparation method of Xingnaojing quick-release buccal tablet

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Experimental program
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Effect test

Embodiment

[0023] 1. Take 9 kilograms of Chinese herbal medicine, coarsely pulverize it, moisten it with 3 times the amount of water (in terms of feeding amount) for about 30 minutes, and decoct it with 18 times the amount of water three times (7 times, 6 times, 5 times). After 1.5 hours, after the initial filtration of the extract, go to the GQ-105 tubular separator for centrifugation while hot, combine the centrifugate, and absorb the D4006 macroporous resin (20-60 mesh) column on the above-mentioned reserve solution, and adjust the flow rate to 1.2 kg / min ( Take a 200*15cm column as an example), wash the resin with about 6 times the amount of water (feeding amount) until the color of the liquid is light (the last 1.5 times is purified water), use 5 times the amount of hot ethanol (60% 50-55°C) at a slow rate (0.8 kg / min), collect the eluate, recover ethanol under reduced pressure and concentrate to 1.0 g / ml (calculated as crude drug), freeze-dry into a dry extract and pulverize, pass t...

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Abstract

The invention relates to a preparation method of a quick-release Xingnaojing lozenge. The preparation method of the quick-release Xingnaojing lozenge comprises the following steps of according to a Xingnaojing prescription amount, carrying out water boiling extraction of active components of cape jasmine fruits, carrying out freeze drying to obtain cape jasmine fruit dry extract, extracting turmeric root-tuber volatile oil by a steam distillation method, carrying out clathration of the turmeric root-tuber volatile oil with beta-cyclodextrin to obtain a turmeric root-tuber volatile oil clathrate, carrying out ethanol reflux extraction of musk active ingredients, dissolving borneol into musk extract obtained by the previous step, carrying out clathration with beta-cyclodextrin to obtain a clathrate of the borneol and the musk active ingredients, respectively crushing the cape jasmine fruit dry extract, the turmeric root-tuber volatile oil clathrate and the clathrate of the borneol and the musk active ingredients, mixing, adding appropriate amounts of auxiliary materials into the mixture, and carrying out processing to obtain the quick-release Xingnaojing lozenge.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a preparation method of medicine, in particular to a preparation method of Xingnaojing quick-release buccal tablets. Background technique [0002] The prescription of Xinnaojing is made from the traditional famous prescription of the motherland——"Angong Niuhuang Pill", which is the representative of Liangkai prescription. Among them, musk is resuscitated and refreshed, which is the monarch drug; Gardenia clears away heat, purifies fire and detoxifies, and clears the fire of the pericardium, and is used as the minister drug; turmeric and borneol are fragrant and filthy, open and close to strengthen the effect of musk for rejuvenating and refreshing Adjuvant medicine, make medicine. Xingnaojing injection made according to this prescription is used for the treatment of: 1. Acute cerebral hemorrhage, cerebral infarction pulmonary encephalopathy, epilepsy, central infection, hypertensive enceph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/20A61P1/16A61P9/10A61P9/12A61P25/00A61P25/08A61P25/28A61P29/00A61P31/12A61P39/02A61P43/00A61K31/045A61K35/55
Inventor 胥宝林俞婷
Owner WUXI JIYU SHANHE PHARM CO LTD
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