The invention discloses a medicine for treating kidney stone and gall-stone, according to a calculus formation pathology and a pharmacological experiment formula, the medicine of the invention is prepared by arbutin, desmodium, lichee nucleus, longan nucleus, common fenugreek seed, gecko, pig iron cinder, gynostemma pentaphylla, plantago, Orthosiphon Stamineus, Caulis aristolochiae manshuriensis, bletilla rhizome, magnolia cortex and sweetleaf tea. The materials are natural-green, safe and reliable. A traditional Chinese medicine toxin expelling therapy is used. The medicine is capable of releasing spasm, relieving pain, smoothing skin, sterilizing, softening hardness and dissipating binds, soothing liver and resolving depression, clearing heat and dispersing stagnate, rectifying qi, disinhibiting urine and freeing strangury and benifiting openheartedness, the medicine can directly act on nidus, an organic matter is subjected to releasing, dissolving and biological enzymatic hydrolysis, can comprehensively permeated in a core of the calculus, the calculus can be cracked, melted and dissolved layer by layer from outer part to inner part, and the waste liquid is excreted through human excretion tissue, and the damaged cells can be activated, the gland can be balanced, the organ vitality can be enhanced, the acid-base value of blood can be balanced, the calculus recurrence can be prevented, and the simultaneous treatment of principal and subordinate symptoms effect can be acted.