Preparation of Supramolecular Hydrogels Using Amphiphilic Small Molecules Based on Cholesterol and Phosphocholine

Abstract

The invention discloses a method for preparing supermolecule hydrogel based on amphiphilic micromolecules (cholesterol and phosphorylcholine). According to the method disclosed by the invention, biomolecule cholesterol and phosphorylcholine are taken as structural elements of the amphiphilic micromolecules, and the biocompatibility of the hydrogel is good; the structures of the amphiphilic micromolecules are very simple, and therefore convenience is provided for synthesizing preparation and the performance of the hydrogel can be adjusted conveniently through the easiest molecular structure change; in addition, the prepared supermolecule hydrogel has the advantages that the hydrogel structure is uniform, various hydrogel performances can not be damaged when outside factors such as pH value and ion strength change, the load capacity is very strong for various other active and functional components, and the moisturizing performance is good. Therefore, the supermolecule hydrogel has very wide potential application prospect on aspects of tissue engineering, medicaments delivery, cell culture, cosmetics, foods, agricultural forestry and gardening and the like.

Description

technical field [0001] The invention relates to a preparation method of an amphiphilic small molecule supramolecular hydrogel, in particular to a method for preparing a supramolecular hydrogel based on amphiphilic small molecules based on cholesterol and phosphorylcholine. Background technique [0002] Hydrogels have been widely concerned because of their excellent properties, and their applications have spread across the fields of biomedicine, daily cosmetics, food industry and even agriculture. In recent years, the focus of research has gradually shifted to the supramolecular hydrogel (LWHG) formed by amphiphilic small molecules, because this hydrogel has a series of special advantages: supramolecular hydrogel itself has good degradability , the performance of the gel is easier to control, the reversibility of the gel process and the more sensitive response to external stimuli make it have greater potential in the production of smart responsive materials. Rational design ...

AI Technical Summary

Problems solved by technology

At present, many supramolecular hydrogels use sugar or oligopeptide as the hydrophilic part. The hydrogels obtained by this design are often easily damaged by the pH value or ionic strength in the environment and lose their gel form; The molecular structure of molecular hydrogels is often complex, which makes preparation difficult and cannot be produced on a large scale; the structure of many supramolecular hydrogels contains strong carcinogens such as condensed ring aromatic hydrocarbons, and there are problems in their biological toxicity

Therefore, the current application of supramolecular hydrogels is greatly limited.

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