Method for removing harmful elements from chinese herbal medicine ficus simplicissima lour.

A technology of harmful elements and Chinese herbal medicines, applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as restricting the export of medicinal materials, affecting the use of medicinal materials, and complexing agent residues, and achieving dual greening , The effect of maintaining the original characteristics and increasing the solubility

Inactive Publication Date: 2014-08-06
SHENZHEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wuzhi Maotao is a bulk medicinal material for export in Guangdong Province, but the export of medicinal materials is seriously restricted due to excessive levels of harmful elements such as Cu, Pb, As, Cd, and Hg.
[0005] However, the application of supercritical coordination / complexation extraction to the removal of harmful elements in medicinal materials also has obvious defects: it takes a long time to react with the organic complex generated by the complexing agent and the metal, and the complexing agent that reacts with the metal needs to Large excess, excessive complexing agent will remain in the medicinal material, affecting the further use of the medicinal material

Method used

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  • Method for removing harmful elements from chinese herbal medicine ficus simplicissima lour.
  • Method for removing harmful elements from chinese herbal medicine ficus simplicissima lour.
  • Method for removing harmful elements from chinese herbal medicine ficus simplicissima lour.

Examples

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Effect test

Embodiment 1

[0027] The removal of harmful elements in the Chinese medicinal material Peach quinquefolium of embodiment 1

[0028] Phosphatidylcholine, provided by Shanghai Bio-Engineering Company; food grade, purity > 95%

[0029] Experimental device: Jiangsu Hua'an supercritical reaction / extraction device, the capacity of the reaction kettle is 1L, the capacity of the extraction kettle is 1L, the capacity of the collection kettle is 2L, the maximum withstand pressure is 35MPa, and the maximum temperature is 368K.

[0030] Preparation method: In one embodiment, the harmful element removal method of the present invention can be completed in a supercritical reaction / extraction device, and the flow chart is as follows figure 1 shown. The specific steps are: mix 20g of phosphatidylcholine [x(PC)=1.5×10 -3 ] dissolved in 200mL ethanol [x(CH 3 CH 2 OH)=0.21], placed in the reactor (8), capped. Simultaneously take by weighing 200g 20~40 order five-finger peach medicinal material granules,...

Embodiment 2

[0038] Harmful element extraction process under the different surfactant dosages of embodiment 2

[0039] This example investigates the effect of microemulsions formed with different surfactant dosages on the element extraction process. Control x(PC) is 3.9×10 -4 ~1.9×10 -3 ,, the amount of ethanol and water are respectively set to x(CH 3 CH 2 OH)=0.21 and x(H 2 O)=0.19, under pressure 15MPa, temperature is 323K, balance reaction 1h, form supercritical microemulsion. Harmful elements in medicinal materials were extracted according to the method of Example 1, the element extract was collected, the content of elements in the extract was measured, and the extraction rate was calculated. The results are shown in Table 2.

[0040] The impact of table 2 phospholipid dosage on the extraction of harmful elements

[0041]

[0042] The results of this example show that when x(PC) is lower than 3.9×10 -4 At this time, micelles cannot be formed, and the desorption effect on el...

Embodiment 3

[0043] The extraction process of harmful elements under the different cosurfactant dosages of embodiment 3

[0044] This example investigates the influence of different ethanol dosages on the extraction process of harmful elements. Control the amount of ethanol x(CH 3 CH 2 OH) is 0.05~0.27, x(PC)=1.5×10 -3 , the amount of deionized water x(H 2 O)=0.19, under pressure 15MPa, temperature is 323K, balance 1h, form supercritical microemulsion. Harmful elements in medicinal materials were extracted according to the method of Example 1, the element extract was collected, the content of elements in the extract was measured, and the extraction rate was calculated. The results are shown in Table 3.

[0045] The results of this example show that in the absence of co-surfactants, phospholipids in supercritical CO 2 Solubility is very small, can not solubilize water to form microemulsion. After adding ethanol, the phospholipids and supercritical CO 2 intermolecular interactions. ...

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Abstract

The invention discloses a method for removing harmful elements Cu, Pb, As, Cd, and Hg from Chinese herbal medicine Ficus simplicissima Lour.msupercritical with a supercritical CO2 microemulsion. The method comprises the steps of: 1) placing a phospholipid / ethanol solution in a supercritical reaction kettle for forming a supercritical CO2 microemulsion under set pressure and temperature; 2) placing the Chinese herbal medicine in an extraction kettle, introducing the supercritical microemulsion to extract the herbal medicine so as to desorb the harmful elements from the herbal medicine and solubilize them in the supercritical microemulsion; and 3) resolving the supercritical microemulsion used for dissolving the harmful elements in a collection kettle, and collecting the precipitated harmful elements. After extraction, the content of harmful elements in the herbal medicine is substantially reduced to meet the export standards. The method of the invention couples supercritical microemulsion with supercritical CO2 extraction, and provides a new non-destructive method for removal of harmful elements from Chinese herbal medicines.

Description

technical field [0001] The invention belongs to the field of safety of traditional Chinese medicinal materials, and in particular relates to a method for removing harmful elements Cu, Pb, As, Cd and Hg from Chinese medicinal material Ficus simplicissima Lour. by using supercritical microemulsion technology. Background technique [0002] For a long time, due to environmental pollution, processing technology pollution and other reasons, the content of harmful elements in some authentic medicinal materials in Guangdong is too high, which has become one of the problems restricting the development of traditional Chinese medicine to the world. Five-finger hair peach is the dry rhizome of Ficus simplicissima Lour., a plant of the genus Moraceae. It is a well-known Cantonese medicine. , deeply loved by Chinese in Guangdong, Guangxi, Hong Kong, Macao and Southeast Asia. Wuzhi Maotao is a bulk medicinal material for export in Guangdong Province, but the export of medicinal materials ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/60
Inventor 文震郑宗坤游新奎蒲一涛石春芝刘剑洪
Owner SHENZHEN UNIV
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