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Medicine composition for treating skin diseases

A technology of composition and medicinal materials, which is applied in the field of disease composition and traditional Chinese medicine composition, can solve the problems of no significant curative effect, failure to meet the treatment of diseases accompanied by itching, no effect, etc.

Inactive Publication Date: 2012-10-10
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they all have side effects, and there is no drug that can satisfy the treatment of itching caused by pruritic skin diseases
Moreover, it has recently been reported that factors other than histamine are involved in the itching of atopic dermatitis. In fact, there are many clinical cases showing that antihistamines and antiallergic drugs have no significant effect on itching in atopic dermatitis.
Antihistamines and topical steroids are sometimes prescribed for the treatment of skin pruritus, but they are almost ineffective, and there is no effective treatment method at present, and there is no medicine that can satisfy the above-mentioned diseases accompanied by pruritus. Drugs that are effective in suppressing itching due to the cause of the disease

Method used

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  • Medicine composition for treating skin diseases
  • Medicine composition for treating skin diseases
  • Medicine composition for treating skin diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1: preparation composition of the present invention

[0086] formula:

[0087] Sophora flavescens

[0088] Preparation method: take 10 herbs except menthol and borneol, reflux extraction with 7.5 times the volume of 75% ethanol twice, each time for 2 hours, concentrate the combined extracts and recover ethanol until the density of the concentrated solution is 1.04g / ml. Add an appropriate amount of ethanol solution of appropriate concentration to the concentrated solution, so that the content of raw medicinal materials and the concentration of ethanol are about 30g / 100ml and about 20% respectively, stir well, let stand overnight, and remove impurities by centrifugal filtration. Dissolve menthol, borneol and ethylparaben (to make the final concentration 0.05%) in an appropriate amount of ethanol, add to the filtrate, stir well, so that the content of raw medicinal materials and the concentration of ethanol are 30g / 100ml and 20% respectively, and t...

Embodiment 2

[0089] Embodiment 2: preparation composition of the present invention

[0090] formula:

[0091] Sophora flavescens

[0092] Preparation method: take 10 herbs except menthol and borneol, reflux extraction with 6 times the amount of 75% ethanol twice, each time for 2 hours, filter; add menthol and borneol to the combined extract, dissolve; The medicinal liquid was concentrated into a thick paste, and dried into powder 8.6g. This dry powder is dissolved with 20% ethanol, prepares the pharmaceutical composition of the present invention, the amount equivalent to raw medicinal material in every 100 grams of this pharmaceutical composition is 30 grams, and this pharmaceutical composition can be used as external solution, liniment, spray and other dosage forms.

Embodiment 3

[0093] Embodiment 3: preparation composition of the present invention

[0094] formula:

[0095] Sophora flavescens

[0096] Preparation method: take 10 herbs except menthol and borneol, extract with 10 times the amount of 50% ethanol under reflux for 1 hour, and filter; then use 5 times the amount of 80% ethanol to reflux extract for 2 hours, filter; Add menthol and borneol to the extract, dissolve; concentrate the liquid into a thick paste, and dry it into powder 12.1g. This dry powder is dissolved in water, and add carbomer to make its amount 5%, and add paraben ethyl ester to make its amount 0.05%, be prepared into the pharmaceutical composition of the present invention that is gel, every 100 grams of this The amount equivalent to raw medicinal materials in the pharmaceutical composition is 30 grams.

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PUM

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Abstract

The invention relates to a medicine composition for treating skin diseases, in particular to a composition which is prepared with Chinese medicinal materials including radix sophorae flavescentis, rhizoma smilacis glabrae, oriental wormwood, golden cypress, rough gentian, cortex dictamni, purslane, broom cypress fruit, stemona, raw liquorice and optional menthol and borneol. The composition remarkably increases an itch irritating field, can effectively suppress mouse ear swelling, and has high expected safety. In addition, the composition can effectively suppress mouse ear swelling caused by dimethylbenzene, and can effectively suppress rat egg white induced paw swelling.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a composition prepared from a variety of traditional Chinese medicines, which can be used to treat or prevent skin diseases such as eczema, pruritus and other diseases. Chinese medicinal composition such as Smilax smilax. Background technique [0002] Skin diseases with eczema and itching as the main symptoms have greatly troubled people's daily work and life. The pathogenesis of eczema is more complicated, and in terms of internal factors, it has an important relationship with the allergic constitution of the body. In addition, excessive fatigue, mental stress, insomnia, gastrointestinal dysfunction, emotional changes, as well as infection lesions, metabolic disorders and endocrine dysfunction, etc., all cause or aggravate the condition of eczema. Eczema can be induced by external stimuli such as heat, sweating, scratching, friction, sunlight, ultraviolet ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P17/00A61P17/04A61K31/045
Inventor 张梅魁徐风华郭荣荣陈婷婷
Owner GENERAL HOSPITAL OF PLA
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