Novel use of sanguinarine chloride

A technology of sanguinarine hydrochloride and thyroid cancer, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, drug combinations, etc., can solve the problems of undiscovered reports on the application of sanguinarine hydrochloride, and achieve Abundant sources, convenient use, and the effect of expanding the therapeutic field

CN102727495AInactive Publication Date: 2012-10-17李超生
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2012-10-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel use of sanguinarine chloride and especially relates to a use of sanguinarine chloride in preparation of a drug for treating a thyroid cancer. In-vivo and in-vitro thyroid cancer experiments prove that sanguinarine chloride has effects of inhibiting or killing thyroid cancer cells, has human papilloma thyroid cancer cells IHH-4 and human anaplastic thyroid cancer cells ASH-3 growth IC50 values of 1.44 micromoles per liter and 2.62 micromoles per liter, and reduces a survival rate of thyroid cancer cells to less than 10%. A nude-mice in-vivo anti-cancer experiment proves that sanguinarine chloride has a transplantation tumor inhibition ratio of 80.81%.
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Description

technical field

[0001] The invention relates to the field of medical applications, in particular to the new application of sanguinarine hydrochloride in the preparation and treatment of cancer. Background technique

[0002] Thyroid cancer is composed of several cancers with different biological behaviors and different pathological types, mainly including papillary adenocarcinoma, follicular carcinoma, undifferentiated carcinoma, and medullary carcinoma. Their age of onset, growth rate, metastasis pathway, and prognosis are all significantly different. For example, the 10-year survival rate of papillary adenocarcinoma is nearly 90%, while the course of undifferentiated cancer is very short, generally only a few months.

[0003] Thyroid cancer accounts for about 1% of all cancers. In endemic nodular goiter endemic areas, the incidence of thyroid cancer, especially poorly differentiated thyroid cancer, is also very high. According to statistics from the International Cancer So...

Examples

Embodiment 1

[0046] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. Embodiment 1: sanguinarine hydrochloride tablet

[0047] 1. Prescription: Sanguinarine hydrochloride 30g, starch 60g, magnesium stearate 2g.

[0048] 2. Preparation method: Weigh the raw and auxiliary materials according to the prescription amount, mix them evenly according to the equal-volume incremental method, and directly compress into tablets to make 1000 tablets.

[0049] 3. Usage and dosage: take orally, 1 tablet each time, 3 times a day.

Embodiment 2

[0050] Embodiment 2: sanguinarine hydrochloride capsules

[0051] 1. Prescription: 30g of sanguinarine hydrochloride, 32ml of 10% hypromellose (10% is 10g / 100ml).

[0052] 2. Preparation method: take raw and auxiliary materials by weighing, granulate, granulate, fill, and make 1000 capsules.

[0053] 3. Usage and dosage: take orally, 1 capsule each time, 3 times a day.

Embodiment 3

[0054] Embodiment 3: Sanguinarine hydrochloride large volume injection

[0055] 1. 40mg of sanguinarine hydrochloride and 2.25g of sodium chloride were used to make sanguinarine hydrochloride sodium chloride injection, the specification of which was 250ml;

[0056] Weigh the raw and auxiliary materials, add 100ml water for injection, stir well to dissolve, add 5-10g activated carbon, heat and boil for 15-30 minutes, cool down the medicinal solution to 40-50°C in circulation, decarbonize and filter; adjust the pH to 6.3-8.3, add Add water for injection to 250ml, fill, sterilize, and inspect with light to get ready.

[0057] 2. 40mg of sanguinarine hydrochloride and 12.5g of glucose, made into sanguinarine hydrochloride glucose injection, the specification is 250ml:

[0058] Weigh the raw and auxiliary materials, add 100ml water for injection, stir well to dissolve, add 5-10g activated carbon, heat and boil for 15-30 minutes, circulate and cool the liquid medicine to 40-50°C, d...