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Method for screening sensitive type intractable epilepsy medicine

A technology for intractable epilepsy and epileptic animals, which is applied in the field of biomedicine and can solve problems such as the lack of experimental control groups

Inactive Publication Date: 2012-10-17
SHANGHAI FIRST PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

Although overexpression of Pgp was detected in epileptogenic brain tissue of human refractory epilepsy, this study lacked a valid experimental control group because it was compared with the level of Pgp expression in corresponding brain tissue of drug-sensitive epilepsy patients. Comparison is impossible - such patients will not be treated surgically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Inhibitory effect of small molecular compound / monoclonal antibody / viral vector carrying small interfering RNA on the expression of P-glycoprotein in the frequency and duration of intractable epileptic seizures.

[0029] 1. Experimental animals: A total of 20 female Sprague-Dawley rats weighing 200-230 g were used as experimental animals, which were purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences.

[0030] 2. Implantation of electrodes:

[0031] Rats were anesthetized by intraperitoneal injection of 1% pentobarbital sodium (40 mg / kg). After the anesthesia was successful, the head of the rat was fixed on a stereotaxic apparatus (Jiangwan Type II). The basolateral nucleus of the amygdala was positioned (AP-2.0mm, ML 5.0mm, VD 8.0mm), and a Teflon bipolar stainless steel electrode with a diameter of 0.2mm was implanted into the basolateral nucleus of the amygdala (BLA )[16] used as stimulating electrodes and recording electrodes; ...

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Abstract

The invention belongs to the biological medicine field, and relates to a method for screening medicines, and concretely relates to a method for screening a sensitive type intractable epilepsy medicine. According to the invention, an epilepsy animal model capable of generating repeatedly spontaneous epileptic seizure is established, the medicine sensitive type and the medicine resistant subgroup are screened by providing the epilepsy animal model anti-epileptic medicine, and the sensitive type intractable epilepsy medicine can be screened according to the expression difference of the corresponding risk factors. The invention provides a novel treatment target and a solution method for solving the problems of drug effect reduction for intractable epilepsy presented in a present clinical application.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a drug screening method, in particular to a method for screening sensitive refractory epilepsy drugs. Background technique [0002] Epilepsy is a common neurological disease characterized by central nervous system dysfunction caused by recurrent abnormal discharge of neurons. Epilepsy controlled by epilepsy drugs is usually called intractable epilepsy clinically. In recent years, great progress has been made in the treatment of the disease with antiepileptic drugs (AEDs) and surgery, but intractable epilepsy is still an important problem for clinicians. This uncontrollable and frequent seizure can lead to serious consequences, including shortened life span, physical trauma, neuropsychological and mental disorders, and social ability impairment, which seriously affects the patient's ability to work and quality of life. , the society and the patient's family bring a heavy mental and econo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 王枫刘振国赵永波
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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