Magnetic field-quadrupole cascade mass spectrum device and magnetic field-quadrupole cascade mass spectrum method with high abundance sensitivity

Abstract

The invention relates to a magnetic field-quadrupole cascade mass spectrum device with high abundance sensitivity, comprising a magnetic mass spectrometer, and an ion speed reduction lens, a quadrupole mass analyzer, a second ion acceleration lens and a terminal ion detector which are sequentially arranged on the tail end of the magnetic mass spectrometer; and the suspension voltage of the quadrupole mass analyzer is 1V to 100V lower than that of the ion source of the magnetic mass spectrometer. The invention aims to provide the magnetic field-quadrupole cascade mass spectrum device and a magnetic field-quadrupole cascade mass spectrum method with high abundance sensitivity, so that the abundance sensitivity of an instrument can be greatly improved.

Description

technical field [0001] The invention belongs to mass spectrometry instrument technology, can be applied to the development and application fields of mass spectrometers, relates to the internal structure and design of mass spectrometers, in particular to magnetic mass analyzers, electrostatic deflection fields, quadrupole mass analyzers and cascade mass spectrometers (also The working principle of the instrument is called tandem mass spectrometry. Background technique [0002] Mass spectrometry is an important branch of contemporary science and technology. The main content it studies is the physical phenomenon that charged atoms or molecules are separated according to the difference in mass-to-charge ratio in the electromagnetic field. By changing the electromagnetic field according to certain parameters, the mass-to-charge ratio spectra of charged atoms and molecules with different mass-to-charge ratios can be obtained, which are called mass spectra. In mass spectrometry, ...

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Problems solved by technology

[0011] The disadvantage of the above two technologies of electrostatic field and retardation lens is that they have no mass selection ability, so these two technologies can only screen for the energy and flight direction of ions, and the abundance sensitivity of magnetic mass spectrometers is also limited by particle scattering, narrow Due to the influence of other conditions such as cracks, the limit of the above two techniques for increasing the sensitivity of abundance is expected to be 1×10 -8 nearby

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