How a quadrupole mass analyzer works

Abstract

The invention relates to a working method of a quadrupole rod mass analyzer. The working method comprises the step of applying RF voltage and DC voltage onto the quadrupole rod mass analyzer and also comprises the step of applying a hybrid frequency signal on the quadrupole rod mass analyzer, the hybrid frequency signal allows ions to be isolated to generate resonance, the ions to be isolated crashes with a quadrupole rod, and the irons to be screened pass through the quadrupole rod mass analyzer. The working method has the advantages of high abundance sensitivity, accurate and reliable analysis result and the like.

Description

technical field [0001] The invention relates to the field of elemental analysis, in particular to a working method of a quadrupole mass analyzer applied to ICP-MS. Background technique [0002] Quadrupole mass analyzer is one of the most mature mass analyzers, and it is widely used in GC-MS, LC-MS and ICP-MS. Quadrupole mass analyzers are low-resolution mass spectrometers, and generally can only achieve unit mass resolution. However, in the application of ICP-MS, the concentration of each element in the sample to be analyzed varies greatly, and the isotopic abundance ratio of some elements also varies greatly. The low resolution of the quadrupole mass analyzer makes the high concentration ion pair The ionic strength of the surrounding mass can produce strong interference, especially when the surrounding mass element concentration is very low for ultratrace analysis or the surrounding mass isotope abundance is very low for isotope ratio measurement. Therefore, the quadrupol...

AI Technical Summary

Problems solved by technology

Quadrupole mass analyzers are low-resolution mass spectrometers, generally only able to achieve unit mass resolution

[0003] At present, the abundance sensitivity index of ICP-MS is generally between 0.1ppm and 1ppm, which cannot meet the requirements for some special occasions, and can only be reduced by optimizing the analysis method, such as increasing matrix separation in sample pretreatment. Influenced by the degree of sensitivity, this method increases the difficulty of sample pretreatment, making sample pretreatment complex and cumbersome, time-consuming and laborious

In addition, for samples with large differences in element concentration and isotopes with large differences in abundance ratio, the abundance sensitivity determines the accuracy of sample analysis, and the accuracy and reliability of the analysis results cannot be guaranteed if the abundance sensitivity is insufficient.