126 results about "Quadrupole mass analyzer" patented technology

A mass spectrometer is configured with individual multipole ion guides, configured in an assembly in alignment along a common centerline wherein at least a portion of at least one multipole ion guide mounted in the assembly resides in a vacuum region with higher background pressure, and the other portion resides in a vacuum region with lower background pressure. Said multipole ion guides are operated in mass to charge selection and ion fragmentation modes, in either a high or low pressure region, said region being selected according to the optimum pressure or pressure gradient for the function performed. The diameter, lengths and applied frequencies and phases on these contiguous ion guides may be the same or may differ. A variety of MS and MS / MSn analysis functions can be achieved using a series of contiguous multipole ion guides operating in either higher background vacuum pressures, or along pressure gradients in the region where the pressure drops from high to low pressure, or in low pressure regions. Individual sets of RF, + / −DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multipole ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide. The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multipole ion guide into an adjacent ion guide. Alternatively ions can be fragmented in one or more multipole ion guides using resonant frequency excitation CID. A multiple multipole ion guide assembly can be configured as the primary mass analyzer in single or triple quadrupole mass analyzers with or without mass selective axial ejection. Alternatively, the multiple multipole ion guide linear assembly can be configured as part of a hybrid Time-Of-Flight, Magnetic Sector, Ion Trap or Fourier Transform mass analyzer.

A multipole ion guide is configured to improve the transmission efficiency of ions which traverse the length of one ion guide and enter either another multipole ion guide such as a quadrupole mass analyzer or a three dimensional ion trap. The ion transfer multipole ion guide radial dimensions are reduced such that the pole assembly and an appropriately shaped exit lens can be positioned within a portion of the internal space defined by the larger radius second multipole ion guide poles. Ions exiting the first ion guide of reduced size find themselves inside the second ion guide close to the centerline. In this manner ions can be efficiently transferred from one ion guide to another, even for those ions with low kinetic energies. In a second embodiment of the invention, the exit region of a multipole ion guide is configured such that the multipole ion guide poles can be extended into a counterbore of a three dimensional ion trap end cap electrode. With this configuration, ions (including those with low kinetic energies) can be transferred into a three dimensional ion trap with increased trapping efficiency.

Disclosed is a quadrupole mass spectrometer, which is capable of, during an SIM measurement, maximally reducing a settling time-period necessary for an operation of changing an input voltage to a quadrupole mass filter in a staircase pattern, and preventing unwanted ions from excessively entering a detector during a course of changing between a plurality of mass values. Under a condition that a response speed of a DC voltage U to be applied to quadrupole electrodes is less than that of an amplitude of a high-frequency voltage V, a control section 10 is operable to rearrange the mass values in descending order of mass value, and an optimal settling-time calculation sub-section 101 is operable to determine a settling time-period for each of the mass values, based on a mass-value difference and a post-change mass value.

Applicant's present invention comprises mass spectrometer systems that operate in a mass range from 1 to 1016 DA. The mass spectrometer system comprising an inlet system comprising an aerodynamic lens system, a reverse jet being a gas flux generated in an annulus moving in a reverse direction and a multipole ion guide; a digital ion trap; and a thermal vaporization / ionization detector system. Applicant's present invention further comprises a quadrupole mass spectrometer system comprising an inlet system having a quadrupole mass filter and a thermal vaporization / ionization detector system. Applicant's present invention further comprises an inlet system for use with a mass spectrometer system, a method for slowing energetic particles using an inlet system. Applicant's present invention also comprises a detector device and a method for detecting high mass charged particles.

An apparatus for electronically controlling a quadrupole in a mass spectrometer, comprises radio frequency (RF) drive circuitry and direct current (DC) drive circuitry coupled to a quadrupole, an RF control loop associated with the RF drive circuitry, a DC control loop associated with the DC drive circuitry, and control loop circuitry associated with the DC control loop, the control loop circuitry configured to alter a response of the DC control loop during a settling time period of a step response such that ion transmission through the quadrupole is greater during the settling time than if the response of the DC control loop during the settling time is unaltered.

The apparatus introduces a second adjustable resonant point in a QMS at a frequency that is close to a multiple of the fundamental frequency by adjusting driving point impedance characteristics of the QMS. The apparatus measures the first and second resonant point of the QMS to account for changes in the operational characteristics of the QMS.

A table (21) for relating an appropriate DC bias voltage to each of a plurality of selectable scan speeds is stored beforehand in an auto-tuning data memory section (20). In an auto-tuning operation, a controller (10) determines the DC bias voltage corresponding to each scan speed by referring to the table (21) and fixes the output of an ion-drawing voltage generator (13) at that voltage. Subsequently, while changing the voltages applied to relevant sections such as an ion optical system (2), the controller (10) finds voltage conditions under which the detection signal is maximized. The conditions thus found are stored in an auto-tuning result data (22). In an analysis of a target sample, a DC bias voltage corresponding to a scan speed specified by an operator is obtained from the DC bias voltage table (21), and the optimal conditions for this voltage are obtained from the auto-tuning result data (22). Based on these items of information, conditions for the scan measurement are determined. This method prevents the deterioration in detection sensitivity, which will otherwise take place if the scan measurement is performed at a high scan speed.

Prior to multiple reaction monitoring (MRM) measurement condition optimization, an analysis operator prepares, for each precursor ion of an objective compound, two lists on a product-ion selection condition setting screen 200, i.e. a list 203 which shows ions to be preferentially selected as product ions for which the optimization needs to be performed and a list 202 which shows ions to be excluded from the optimization. When a measurement is performed, a product-ion scan measurement for the precursor ion of the objective compound is performed and a spectrum is obtained. Among the ions extracted from this spectrum, any ion registered in the excludable-ion list 202 is excluded, while any ion registered in the preferred-ion list 203 is preferentially selected as a product ion. For each combination of the m / z values of the precursor ion and the product ions thus determined, optimum conditions of the MRM measurement are searched for.

The invention relates to a multiphase catalytic reaction device for testing in situ solid-state nuclear magnetic resonance, which is a magic angle spinning multiphase catalytic reactor in which an online solid-state nuclear magnetic resonance system, a quadrupole mass-spectrometer, a gas chromatograph and a laser-induced hyperpolarized 129Xe isotope probe are linked for use. The reactor can apply various solid-state nuclear magnetic resonance techniques to track and detect a catalyst structure, reaction intermediates and species with catalyst activity in the catalytic reaction process; reaction products are qualitatively and quantitatively analyzed by the quadrupole mass-spectrometer and the gas chromatograph, so that the performance of the catalyst is evaluated; simultaneously, laser-induced hyperpolarized 129Xe isotope is used as a probe molecule to study the change of the catalyst structure, adsorption positions and diffusion behaviors of various species in the reaction process and the like. In-situ tracking in the catalytic reaction process and the mechanism of the catalytic reaction can be systematically studied through the various techniques.

An apparatus for electronically controlling a quadrupole in a mass spectrometer, comprises radio frequency (RF) drive circuitry and direct current (DC) drive circuitry coupled to a quadrupole, an RF control loop associated with the RF drive circuitry, a DC control loop associated with the DC drive circuitry, and control loop circuitry associated with the DC control loop, the control loop circuitry configured to alter a response of the DC control loop during a settling time period of a step response such that ion transmission through the quadrupole is greater during the settling time than if the response of the DC control loop during the settling time is unaltered.

A method of aligning sets of cylindrical electrodes in the geometry of a miniature quadrupole electrostatic lens, which can act as a mass filter in a quadrupole mass spectrometer is provided. The electrodes are mounted in pairs on microfabricated supports, which are formed from conducting parts on an insulating substrate. Complete segmentation of the conducting parts provides low capacitative coupling between co-planar cylindrical electrodes, and allows incorporation of a Brubaker prefilter to improve sensitivity at a given mass resolution. A complete quadrupole is constructed from two such supports, which are spaced apart by further conducting spacers. The spacers are continued around the electrodes to provide a conducting screen.

The invention discloses a system and method for measuring plume multi-component space distribution in vacuum low-temperature environment. A quadrupole mass spectrometer is adopted as a core instrument for measuring plume components of a motor, and the mass spectrometer is connected into a vacuum chamber through a drainage pipeline; a plume component probe is mounted at the other end of the drainage pipeline; the plume component probe is mounted on a three-dimensional moving mechanism through a switching piece; and the measurement of plume space components of the motor is achieved under the traction of the three-dimensional moving mechanism. In the system, control reformation and temperature control reformation are performed on a driving motor of the three-dimensional moving mechanism so as to enable three-dimensional moving mechanism to work in the vacuum low-temperature environment, and sealing treatment is performed on the terminals of various circuits so as to effectively prevent a Barson breakdown effect; meanwhile, temperature control is performed on the drainage pipeline. The system and the method have the advantages of achieving one-time measurement of plume multi-component space distribution of the motor in the vacuum low-temperature environment, being economical and simple, and ensuring accurate and visual data and convenient data post-processing.

In a scan measurement in which a mass scan is repeated across a predetermined mass range, when a voltage is returned from a termination voltage of one scan to an initiation voltage for the next scan, an undershoot or other drawbacks occur to destabilize the voltage value. Therefore, an appropriate waiting time is required. Conventionally, this waiting time has been set to be constant regardless of the analysis conditions. On the other hand, in the quadrupole mass spectrometer according to the present invention, the mass difference ΔM between the scan termination mass and the scan initiation mass is computed based on the specified mass range, and a different settling time is set in accordance with this mass difference. When the mass difference ΔM is small and hence requires only a short voltage stabilization time, a relatively short settling time is set. This shortens the cycle period of the mass scan, which increases the temporal resolution.

If a scanning rate of a mass scanning is set to be high, the amount of change in an applied voltage between a time of an incidence of a certain ion into a quadrupole mass filter and a time of an emission of the ion therefrom increases. This leads to a change in the condition of a passage of ions, causing the amount of ions to decrease and thereby deteriorating detection sensitivity. In order to avoid this problem, according to the present invention, the values of direct current voltage U and an amplitude V of radio-frequency voltage, both voltages being applied to rod electrodes during a mass scanning, are respectively determined so that a voltage ratio U / V of the voltage U to the amplitude V becomes smaller as the scanning rate becomes higher. Accordingly, in a stability diagram based on the Mathieu equation, the inclination of line L indicating the change in the applied voltage during the mass scanning becomes gradual and the amount of ions passing through the quadrupole mass filter increases particularly when the mass is high.

In a quadrupole mass spectrometer which measures partial pressure strength according to a gas type in a vacuum system from ion current intensity, a quadrupole mass spectrometer with a total pressure measurement electrode has a total pressure measurement electrode for examining an ion density disposed in a demarcation space which is comprised of a grid electrode and an ion focusing electrode. And, a vacuum system is provided with only the quadrupole mass spectrometer which measures partial pressure strength according to a gas type in the vacuum system from an ion current intensity and does not have an ionization vacuum gauge other than the quadrupole mass spectrometer.

A mass analyzer for use in a mass spectrometry system comprises an elongate rod set. The rod set has first and second ends and an inscribed circle within the rod set. The radius of the rod set varies from one end of the rod set to the other, so that ions of different mass to charge ratios will become unstable at different locations along the rod set. This characteristic can then be used to cause ejection of ions at different locations along the rod set, in a mass dependent manner. Detectors placed linearly along the rod set can then be used to detect ions and determine the mass of the ions from their ejection locations.

The utility model relates to a quadrangular frustum shaped four-stage mass analyzer with stepped electrodes, comprising four electrodes. The four electrodes can form a space zone, the electrode shape is trapezoid, and the stepped protruding ridge is arranged on the trapezoid electrodes. Two of the four electrodes can form a quadrangular frustum space zone along a bevel edge of the trapezoid respectively. The utility model has the advantages of simple structure and low production difficulty, low production and service costs of the quadrapole spectrometer and wide application.

Provided are a leakage inspection apparatus and a leakage inspection method for inspecting the flow rate of leakage from a tested body disposed in a tested-body chamber 21. The leakage inspection apparatus includes liquid supplying and pressurizing means 11 for supplying a probe liquid to the inside of the tested-body chamber 21 and pressurizing the probe liquid to a high pressure 0.1 MPa or more, vacuum evacuation means 22-b, 23-b and a quadrupole mass spectrometer 34. The tested body 21 is evacuated, the probe liquid is supplied to the inside of the tested body and pressurized to 0.1 MPa or more and the concentration of a probe medium leaked from the tested body and evaporated in a vacuum is measured by the quadrupole mass spectrometer 34, thereby measuring the flow rate of leakage from the tested body. This makes it possible to determine the flow rate of leakage using a liquid as a probe medium and simultaneously possible to perform a pressure tightness inspection at an atmospheric pressure of 0.1 MPa or more, especially at a high pressure ranging from 1 MPa to 1 GPa.

A method for linearizing the sensitivity of a quadrupole mass spectrometric system to allow the sensor to more accurately report partial pressures of a gas in high pressure areas in which the reported data is effected by a number of loss mechanisms. According to the invention, correction factors can be applied empirically or software in a quadrupole mass analyzer system can be equipped with correcting software to expand the useful range of the mass spectrometer.

In a scan measurement in which a mass scan is repeated across a predetermined mass range, when a voltage is returned from a termination voltage of one scan to an initiation voltage for the next scan, an undershoot or other drawbacks occur to destabilize the voltage value. Therefore, an appropriate waiting time is required. Conventionally, this waiting time has been set to be constant regardless of the analysis conditions. On the other hand, in the quadrupole mass spectrometer according to the present invention, the mass difference ΔM between the scan termination mass and the scan initiation mass is computed based on the specified mass range, and a different settling time is set in accordance with this mass difference. When the mass difference ΔM is small and hence requires only a short voltage stabilization time, a relatively short settling time is set. This shortens the cycle period of the mass scan, which increases the temporal resolution.

The invention discloses a material partial pressure gas-release rate test device and method. The device comprises a measuring chamber, a vacuum pump set and a current limiting small hole. The vacuum pump set is connected to the measuring chamber by a gate valve. The front end of the current limiting small hole is connected to the measuring chamber by an angle valve and the rear end of the current limiting small hole is directly connected to the vacuum pump set. Through a quadrupole mass spectrometer and an extractor gauge, base partial pressure values and base nitrogen equivalent total pressure values of different types of gas in the empty measuring chamber and the measuring chamber with a sample are measured so that a sample nitrogen equivalent partial pressure gas-release rate is measured. Only through one quadrupole mass spectrometer, real-time and continuous measurement of a material partial pressure gas-release rate is realized, gas secondary adsorption caused by pressure increasing produced by gas release of a vacuum material in the measuring chamber is reduced and lateral comparison of gas with different components is convenient.

The invention aims to provide a method for testing hydrogen diffusivity or permeability in metal with higher accuracy, and a specific device therefor. The invention is characterized in that the device consists of a sample chamber, an evacuating system, a double-sphere-shaped vacuum chamber, a quadrupole mass-spectrometer, a hydrogen standard leak, a pressure testing system, a vacuum testing system and pipes, wherein both ends of the sample chamber are connected with the evacuating system through the pipes; one end of the sample chamber is connected with a hydrogen source; the pressure testing system is arranged between the sample chamber and the hydrogen source; the upper spherical vacuum chamber of the double-sphere-shaped vacuum chamber is respectively connected with the other end of the sample chamber, the hydrogen standard lead and the quadrupole mass-spectrometer; the lower spherical vacuum chamber of the double-sphere-shaped vacuum chamber is connected with the evacuating system.

The invention discloses a low-temperature enrichment and concentration online high-sensitivity quadripole mass spectroscopy analysis system which comprises a vacuum pump unit, a sample chamber, an analysis chamber, a quadripole mass spectroscopy, a first valve, a second valve and a low-temperature concentrator. The sample chamber, the first valve, the low-temperature concentrator, the analysis chamber, the second valve and the vacuum pump unit are connected in sequence. The analysis chamber is further connected with the quadripole mass spectroscopy. The vacuum pump unit provides needed vacuum degree for the quadripole mass spectroscopy, then, sample gas in the sample chamber is introduced into the analysis chamber through the low-temperature concentrator and analyzed by the quadripole mass spectroscopy. According to the low-temperature enrichment and concentration online high-sensitivity quadripole mass spectroscopy analysis system, the analysis sensitivity of the quadripole mass spectroscopy for trace impurity gas, particularly organic impurity gas is remarkably improved in the vacuum environment.

A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped / cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement throughput is obtained by applying the laser to each sample spot on the target for an irradiation duration significantly shorter than the time required to deplete the sample material in the sample spot. The irradiation duration may be set based on a determination of the MRM peak broadening caused by the ion optics. This allows significantly reduced widths of the MRM peaks while maintaining good signal to noise ratios and provides a significantly improved throughput of the quantitation analyses as well as improved reproducibility of the MRM peaks and reduced compound dependence of the MRM peak widths.

Quadrupole mass spectrum tube for analyzing residual gas in electrovacuum device includes quadrupole mass analyzer, ion source and ion detector. Cerametallies quadrupole mass analyzer is adopted in the invention. Porcelain tube is as vacuum body case. Four poles of quadrupole mass analyzer are in cavity of porcelain tube. Metallized electric layer is setup at two edge faces of the analyzer in order to prevent charge accumulation. Leading needle of metal pole passing through metallized hole in the porcelain tube from metallized electric layer or inner faces of four poles is led out of cavity of vacuum porcelain tube. Connection between porcelain tube and vacuum cavity of ion source and ion detector is vacuum sealed connection of metal-ceramics.

An improved ion optical lens designed to increase the amount of ion current delivered into a multi-pole ion detector or transfer device, such as quadrupole mass analyzer, an ion guide, collision cell, etc. A device and method is disclosed that utilizes a tubular entrance lens to introduce ions into or sample ions at a field-free or near field-free region disposed at the junction of two sets of multi-pole assemblies operating with radio frequency potentials shifted 180 degrees out of phase with respect to each other. The method is useful for increasing the transport of ions into as they enter into or exit out of a multi-pole mass analyzer, such as a quadrupole mass analyzer, an ion guide, collision cell, etc.

The present invention relates to a quadrupole mass analyzer which is a core equipment of a majority of mass analyzer, particularly to a quadrupole mass analyzer with a hyperbolic surface made of quartz which is capable of enhancing resolving power and analytical performance of a mass analyzer. The quadrupole mass analyzer according to the present invention includes four quartz tubes separated by predetermined distance to form a shape of rotation symmetry and being parallel to each other; an electric part formed with a predetermined area by a platinum membrane being divided into a prefilter electrode part and a main filter electrode part in a longitudinal direction of the quartz tube in a circumferential surface in an axial direction of the rotation symmetry of the quartz tube, a cross-section of the platinum membrane on an opposing quartz tube forming a substantial hyperbolic surface; a quartz pin being chamfered at both ends in a shape with a same radius curvature as the quartz tube and being closely fixed between the adjacent quartz tubes; and an electrically conductive connection member electrically connecting each of prefilter electrode parts and main filter parts of the opposing quartz tubes so as to apply RF and DC electric source.