The invention discloses a method for measuring gas pressure of a coal seam by a casing high-pressure hole sealing method. The method comprises the following steps: a, a hole is opened with a large-diameter drill bit, the depth of a casing can be increased by drilling, and then the casing with a flange at the outer end is sent into the hole; b, expansive cement mortar is injected into the hole in a grouting mode to enhance the casing; c, after the expansive cement mortar is solidified, drilling is carried out with a drill bit which is one size smaller than the large-diameter drill bit in step a along the original drilling center, the drilling is stopped when a coal seam is approached, and the expansive cement mortar is injected into a whole-hole section in a grouting mode for reinforcement after drilling cuttings are removed; d, after the expansive cement mortar is solidified, the hole is drilled with a drill bit which is one size smaller than the drill bit in step c along the original drilling center until the coal seam is penetrated; and e, the flange at the outer end of the casing is connected with a pressure gage to measure gas pressure. Large and small gaps and gap water around the drill hole can be effectively blocked in a high-pressure grouting method, an air leak channel is sealed, and rapid and accurate pressure measurement is realized.