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Targeted nanoscale ultrasonic microbubble

An ultrasonic microbubble and nanoscale technology, applied in echo/ultrasonic imaging agents and other directions, can solve the problems of low targeting of ultrasound contrast agent microbubbles, low tissue penetration, and weak specificity, and achieve tissue targeting. High, low immunogenicity, easy to express effect

Inactive Publication Date: 2012-12-12
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a high targeting, tissue A targeted nanoscale ultrasonic microbubble with strong penetrating power, small molecular weight, high affinity, good stability and strong specificity

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  • Targeted nanoscale ultrasonic microbubble
  • Targeted nanoscale ultrasonic microbubble
  • Targeted nanoscale ultrasonic microbubble

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Embodiment Construction

[0016] Such as figure 1 As shown, a targeted nanoscale ultrasonic microbubble of the present invention includes a lipid bimolecular shell and a biologically inert gas wrapped inside the lipid bilayer shell, and is connected with a targeting nanometer on the lipid bimolecular shell Antibody; particle size between 300-700nm; lipid bimolecular shell consisting of the following components: palmitoylphosphatidylcholine, distearoylphosphatidylcholine-polyethylene glycol 2000 and distearoylphosphatidylcholine Choline-polyethylene glycol 2000-biotin; streptavidin is also included, and the targeting nanobody is modified with biotin to form a biotinylated nanobody, and one end of streptavidin is connected to the two Stearoylphosphatidylcholine-polyethylene glycol 2000-biotin linkage, one end is linked to biotinylated Nanobody.

[0017] In the specific implementation process, the biologically inert gas is selected as perfluoropropane C 3 f 8 The targeting nanobody is selected as a nan...

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Abstract

The invention discloses a targeted nanoscale ultrasonic microbubble, which comprises a lipid bilayer shell and a biological inert gas, wherein the biological inert gas is packaged in the lipid bilayer shell; the lipid bilayer shell is connected with targeted nanometer antibodies. According to the targeted nanoscale ultrasonic microbubble disclosed by the invention, the defects of low targeting, low tissue penetration, low appetency, low stability and low specificity of a traditional ultrasonic contrast agent microbubble are overcome. The invention provides the targeted nanoscale ultrasonic microbubble which is high in targeting, high in tissue penetration, low in molecular weight, high in appetency, high in stability and high in specificity.

Description

technical field [0001] The invention belongs to the field of medical preparations, in particular to a targeted nano-scale ultrasonic microbubble. Background technique [0002] At present, since Gramiak first discovered tiny air bubbles that can enhance ultrasound imaging in 1967, ultrasound contrast agents (UCAs) have been continuously developed, and at the same time guided the development of new technologies for ultrasound detection. Going deeper, ultrasound contrast agents not only play an important role in ultrasound imaging, but also become an important carrier in drug delivery. Therefore, ultrasound molecular imaging technology based on ultrasound contrast agents combined with contrast-specific imaging technology, It has been clinically used in the diagnosis, treatment and evaluation of certain diseases. Ultrasound contrast agents are divided into micron-scale and nano-scale according to the particle size of the microbubbles. Sulfur and other gases are formed; and nan...

Claims

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Application Information

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IPC IPC(8): A61K49/22
Inventor 郭燕丽范校周
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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