Targeted nanoscale ultrasonic microbubble
An ultrasonic microbubble and nanoscale technology, applied in echo/ultrasonic imaging agents and other directions, can solve the problems of low targeting of ultrasound contrast agent microbubbles, low tissue penetration, and weak specificity, and achieve tissue targeting. High, low immunogenicity, easy to express effect
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[0016] Such as figure 1 As shown, a targeted nano-level ultrasound microbubble of the present invention includes a lipid bimolecular shell and a biologically inert gas wrapped inside the lipid bimolecular shell, and a targeting nanometer is connected to the lipid bimolecular shell. Antibody; particle size is between 300-700nm; lipid bimolecular shell includes the following components: palmitoylphosphatidylcholine, distearoylphosphatidylcholine-polyethylene glycol 2000 and distearoylphosphatidyl Choline-polyethylene glycol 2000-biotin; also includes streptavidin, the targeting nanobody is modified by biotin to form a biotinylated nanobody, and one end of streptavidin is connected to the two Stearoylphosphatidylcholine-polyethylene glycol 2000-biotin is connected, and one end is connected to the biotinylated nanobody.
[0017] In the specific implementation process, the bio-inert gas is selected as perfluoropropane C 3 F 8 , Targeting Nanobody is selected as the Nanobody against Pr...
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