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Modeling method for biochemical reaction process of immunochromatography test strip

A biochemical reaction and immunochromatography technology, which is applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the problems of modeling quantitative immunochromatography test strips without immunochromatography test strips, etc.

Active Publication Date: 2012-12-12
FUZHOU UNIV
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  • Description
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  • Application Information

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Problems solved by technology

At present, researchers have attached great importance to the research on the quantitative testing of nano-gold immunochromatographic test strips, but they have not modeled the immunochromatographic test strips to assist the development of quantitative immunochromatographic test strips.

Method used

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  • Modeling method for biochemical reaction process of immunochromatography test strip
  • Modeling method for biochemical reaction process of immunochromatography test strip
  • Modeling method for biochemical reaction process of immunochromatography test strip

Examples

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Effect test

Embodiment 1

[0066] Embodiment 1: Carry out the modeling method of immunochromatographic quantitative determination reaction process with extended Kalman filter method

[0067] According to our observational data obtained from experimental measurements, see figure 2 , and then set the initial values ​​of the estimated state, parameters, system noise and observation noise variance to identify the model. The result is as follows:

[0068] The extended Kalman filter algorithm estimates the changes of various substances in the immunochromatographic test strips, see image 3 ; For the model parameters estimated by the extended Kalman filter algorithm, see Figure 4 ; The model established by the extended Kalman filter algorithm verifies the Hook effect, see Figure 5 ; Verify the validity of the model established by the extended Kalman filter algorithm Figure 6 .

Embodiment 2

[0069] Embodiment 2: Carry out the modeling method of immunochromatographic quantitative determination reaction process with particle filter method

[0070] According to our observational data obtained from experimental measurements, see figure 2 , and then set the initial values ​​of the estimated state, parameters, system noise and observation noise variance to identify the model. The result is as follows:

[0071] The particle filter algorithm estimates the changes of various substances in the immunochromatography test strips, see Figure 7 ; For the model parameters estimated by the particle filter algorithm, see Figure 8 .

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Abstract

The invention relates to the technical field of the quantitative determination of an immunochromatography test strip, in particular to a modeling method for the biochemical reaction process of the immunochromatography test strip on the basis of the nonlinear estimation theory. According to the immunochromatography reaction mechanism, a state space model is adopted in the modeling method to describe the immunoreaction process of an antigen and an antibody in the test strip after various noises and interferences of the test strip are comprehensively considered, and the model is distinguished according to observation data measured in an experiment with a nonlinear estimation method. According to the model constructed with the modeling method, the immunoreaction process of the antigen and the antibody in the test strip can be described so as to detect the influence of each design parameter in the test strip and optimize the characteristics of the test strip, and guarantee is provided for realizing the quantitative determination of the immunochromatography test strip.

Description

technical field [0001] The invention relates to the technical field of quantitative determination of immunochromatographic test strips, in particular to a modeling method for the biochemical reaction process of immunochromatographic test strips based on nonlinear estimation theory. Background technique [0002] Immunoassay (Immunoassay, IA) is a method that uses antigen-antibody reaction to detect trace substances in specimens. Based on the specificity and sensitivity of antigen-antibody reactions, immunoassays are used in many fields of medical testing. Any substance can be detected by immunoassay as long as the corresponding specific antibody can be obtained. As a simple and rapid test method, Gold Immunochromatographic assay (GICA) is a solid-phase labeling immunoassay technology that combines colloidal gold labeling technology, immunoassay technology and chromatographic analysis technology. Compared with isotope, fluorescein, chemiluminescence and other labeling techno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/12
Inventor 曾念寅杜民王子栋李玉榕
Owner FUZHOU UNIV
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