Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles

A hydroxyapatite and nano-needle technology, applied in the field of biomedical materials, can solve the problems of toxic sodium fluoride and environmental hazards.

Inactive Publication Date: 2014-07-02
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, sodium fluoride is often added to toothpaste to prevent caries, but sodium fluoride is toxic and harmful to the environment, while nano-hydroxyapatite has a certain adsorption effect, and nano-hydroxyapatite has no toxic side effects , no pollution to the environment, so the use of nano-hydroxyapatite particles to adsorb and remove these substances related to plaque formation is of great significance to oral health care

Method used

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  • Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles
  • Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles
  • Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method for preparing hydroxyapatite nanoneedles, comprising the following steps:

[0033] (1) Take 700mL of deionized water and add it to a 1000mL plastic beaker, put it in a collector type magnetic stirrer, oil bath, magnetic stirring, set the temperature at 37°C. 8.035g NaCl, 0.355g NaHCO 3 , 0.225g KCl, 0.231g K 2 HPO 4 ·3H 2 O, 0.311g MgCl 2 ·6H 2 O, 39mL 1.0M HCl, 0.292g CaCl 2 , 0.072g Na 2 SO 4 , 6.118g NH 2 C(CH 2 Oh) 3 (Tris) was added to deionized water at 37°C in order to obtain a colorless and transparent solution. Add deionized water to bring the solution to 900mL, measure the pH value of the solution at this time, and add 1.0M-HCl or Tris (2 -amino-2-(hydroxymethyl)-1,3-propanediol) to adjust the pH value of the solution to 7.40, and finally use a volumetric flask to set the volume to 1000mL to obtain a simulated body fluid solution.

[0034] (2) In a constant temperature water bath at 37°C, under stirring conditions, mix 1MK 2 HPO 4 ·3H 2...

Embodiment 2

[0037] A method for preparing hydroxyapatite nanoneedles, comprising the following steps:

[0038] (1) Take 700mL of deionized water and add it to a 1000mL plastic beaker, put it in a collector type magnetic stirrer, oil bath, magnetic stirring, set the temperature at 37°C. 8.035g NaCl, 0.355g NaHCO 3 , 0.225g KCl, 0.231g K 2 HPO 4 ·3H 2 O, 0.311g MgCl 2 ·6H 2 O, 39mL 1.0M HCl, 0.292g CaCl 2 , 0.072g Na 2 SO 4 , 6.118g NH 2 C(CH 2 Oh) 3 Add (Tris) to 37°C deionized water in order to obtain a colorless and transparent solution, add deionized water to make the solution to 900mL, measure the pH value of the solution at this time, and add 1.0M-HCl or Tris (2 -amino-2-(hydroxymethyl)-1,3-propanediol) to adjust the pH value of the solution to 7.40, and finally use a volumetric flask to set the volume to 1000mL to obtain a simulated body fluid solution.

[0039] (2) In a constant temperature water bath at 37°C, under stirring conditions, mix 1MK 2 HPO 4 ·3H 2 30ml of O...

Embodiment 3

[0042] A method for preparing hydroxyapatite nanoneedles, comprising the following steps:

[0043] (1) Take 700mL of deionized water and add it to a 1000mL plastic beaker, put it in a collector type magnetic stirrer, oil bath, magnetic stirring, set the temperature at 37°C. 8.035g NaCl, 0.355g NaHCO 3 , 0.225g KCl, 0.231g K 2 HPO 4 ·3H 2 O, 0.311g MgCl 2 ·6H 2 O, 39mL 1.0M HCl, 0.292g CaCl 2 , 0.072g Na 2 SO 4 , 6.118g NH 2 C(CH 2 Oh) 3 Add (Tris) to 37°C deionized water in order to obtain a colorless and transparent solution, add deionized water to make the solution to 900mL, measure the pH value of the solution at this time, and add 1.0M-HCl or Tris (2 -amino-2-(hydroxymethyl)-1,3-propanediol) to adjust the pH value of the solution to 7.40, and finally use a volumetric flask to set the volume to 1000mL to obtain a simulated body fluid solution.

[0044] (2) In a constant temperature water bath at 37°C, under stirring conditions, mix 1MK 2 HPO 4 ·3H 2 30ml of O...

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Abstract

The invention discloses a preparation method for synthesizing hydroxyapatite nanoneedles by simulating body fluid method, using simulated body fluid as reaction solvent, CaCl2 as calcium source, K2HPO4·3H2O as phosphorus source, under the condition of P / Ca ratio of 1.5-1.6 A rod-shaped hydroxyapatite nanoneedle with a width of about 2-20nm and a length of 50-80nm was synthesized. The method of the present invention prepares hydroxyapatite nanoneedles without pH adjustment and subsequent high-temperature sintering, and the reaction time is short. The obtained hydroxyapatite nanoneedles are similar to hydroxyapatite in human teeth, and have adsorption activity for dental bacteria, and It has no toxic and side effects and is of great significance to oral health care.

Description

Technical field [0001] The present invention is a technical field of biomedical materials, which specializes in the preparation method of a hydroxylite nanopotic needle, as well as the hydroxylhhexylite nanopotic needle made by this method. Background technique [0002] Hydroxylhhelite is an important component of biological body bone tissue and provides the necessary strength and hardness for bones.Artificial synthetic hydroxyl -based limestone has excellent biocompatibility, biological activity, bone conduction performance, and no biological toxicity, so it is widely used in medical fields such as bone replacement and bone repair. [0003] At present, there are many ways to synthesize hydroxyl -based limestone, but in the process of synthetic hydroxypephyolithic glycosis, high pH value, high reaction temperature, long response time, the product needs subsequent sintering treatment, and the synthetic hydroxylhstine is in the crystalline crystallizationIn terms of nature and stru...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor莫祥银丁林飞金传伟丁毅孙卫斌
OwnerNANJING NORMAL UNIVERSITY