Skin hyperpigmentation acyl glutathione treatments

Abstract

Topical compositions for treatment of hyperpigmentation comprise an effective amount of S-acyl glutathione derivative and a carrier. Methods for treating hyperpigmentation, such as melasma, postinflammatory hyperpigmentation and lentigines, skin lightening and skin whitening comprise applying a composition containing S-acyl glutathione derivative in a dermatologically acceptable carrier to skin tissue. The acyl group is a saturated or unsaturated aliphatic C12-C24 group, preferably a C16-C24 group, most preferably a C16 group. In particularly preferred embodiments, the S-acyl glutathione derivative is S-palmitoyl glutathione.

Description

field of invention [0001] The present invention relates to topical compositions comprising glutathione derivatives. More specifically, the present invention relates to topical compositions comprising glutathione acyl derivatives for skin lightening, skin lightening and treatment of skin hyperpigmentation. Background of the invention [0002] Reduced glutathione, commonly referred to as glutathione or GSH, is a relatively small molecule found in plants and animals with the following formula: [0003] [0004] Glutathione is an orthomolecule in water. It is the smallest intracellular thiol molecule. Due to its remarkable electron-donating ability, it is an effective reducing compound. Glutathione is a potent antioxidant and enzyme cofactor that plays an important role in regulating cellular activity. [0005] Glutathione is a chain tripeptide of L-glutamine, L-cysteine ​​and glycine. Academically, N-L-γ-glutamyl-cysteinylglycine or L-glutathione, the molecule has a sul...

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