Application of medicinal composition for treating diabetes mellitus

Abstract

The invention provides application of a Tibetan medicinal composition in preparing a medicament for treating diabetes mellitus. The Tibetan medicinal composition consists of the following raw material drugs in parts by weight: 60 to 600 parts of gymnadenia conopsea, 30 to 300 parts of radix pleurospermi tibetanici, 40 to 400 parts of sealwort, 30 to 300 parts of radix mirabilis himalaicae, 40 to 400 parts of asparagus fern, 10 to 100 parts of cordyceps sinensis, 30 to 300 parts of cynomorium songaricum, 10 to 100 parts of caltrop, 4 to 45 parts of przewalskia tangutica, and 50 to 500 parts of myrobalan. Tests prove that the medicinal composition can remarkably improve the physical sign of a patient, and has remarkable improvement to fasting plasma-glucose (FPG), 2 hour postprandial blood glucose (PBG), urinary albumin excretion rate (UAE), microalbuminuria (MAV) and glycosylated hemoglobin (HbAlc).

Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of medicines for preventing and treating diabetes. Background technique

[0002] Diabetes is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body to cause hypofunction of islets of pancreas and insulin resistance. A series of metabolic disorder syndromes. Various acute and chronic complications brought about by diabetes seriously endanger people's health, and if they are not treated in time, they can be life-threatening. According to the survey of the World Health Organization, there are currently 160 million diabetic patients in the world, and there are more than 40 million diabetic patients in my country, accounting for about a quarter of the global diabetic patients, and the onset of diabetes te...

Examples

Embodiment 1

[0021] Embodiment 1, a kind of preparation of compound hand ginseng pharmaceutical composition granule

[0022] The ratio of raw materials is: hand ginseng 180g, Tibetan celery 90g, Polygonatum 130g, Himalayan mirabilis 90g, Asparagus 130g, Cordyceps 30g, Cynomorium 90g, Tribulus terrestris 30g, horse urine bubble 10g, myrobalan 160g;

[0023] (1) Take ginseng, Tibetan celery, Polygonatum, Mirabilis Himalayan, Radix Asparagus, Cynomorium terrestris, Tribulus terrestris, horse urine foam, and myrobalan fruit according to the composition ratio of raw materials; the volume concentration of adding 8 times the total weight of medicinal materials is 70% The ethanol solution was refluxed and extracted twice, each time for 2 hours, filtered, and the dregs A were used for later use, the ethanol extract was combined, the ethanol was concentrated under reduced pressure, and the concentration was continued to a thick paste with a relative density of 1.25 at 50°C to obtain ethanol extract B...

Embodiment 2

[0026] Embodiment 2, the preparation of a kind of medicine composition pellet of the effective part of compound hand ginseng

[0027] The composition ratio of the raw material medicine is: hand ginseng 197.3g, Tibetan lentil celery 98.0g, sealwort 133.3g, Himalaya mirabilis 98.0g, asparagus 133.3g, cordyceps 32.7g, Cynomorium 98.0g, tribulus terrestris 32.7g, horse urine bubble 13.6g g. Myrobalan 163.3g;

[0028] (1) According to the ratio of raw materials, 5 kinds of medicinal materials, including Tibetan celery, Himalayan mirabilis, Tribulus terrestris, horse urine bubble and myrobalan, were extracted twice with ethanol with a volume fraction of 50%. The amount of ethanol added for the first time was 8 times of the total weight of the original medicinal materials, the amount of ethanol added for the second time is 6 times of the total weight of the original medicinal materials, extracted for 2 hours each time, filtered, and combined with the ethanol extract to obtain ethanol...

Embodiment 3

[0034] Embodiment 3, a kind of preparation of compound hand ginseng pharmaceutical composition tablet

[0035] Ginseng 200g, Celery 100g, Polygonatum 135g, Mirabilis Himalayan 100g, Asparagus 135g, Cordyceps 35g, Cynomorium 100g, Tribulus terrestris 35g, Horse urine bubble 15g, Myrobalan 165g;

[0036] (1) Take ginseng, Tibetan celery, Polygonatum, Mirabilis Himalayan, Radix Asparagus, Cynomorium terrestris, Tribulus terrestris, horse urine foam, and myrobalan fruit according to the composition ratio of raw materials; add 6 times the total weight of medicinal materials to a volume concentration of 50% The ethanol solution was refluxed and extracted twice, each time for 2 hours, filtered, the dregs A were set aside, the ethanol extract was combined, the ethanol was concentrated under reduced pressure, and dried to obtain ethanol extract B;

[0037] (2) Take medicinal residue A, reflux extract 3 times with water 6 times the total weight of the medicinal materials, extract for 2 ...

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of medicines for preventing and treating diabetes. Background technique

[0002] Diabetes is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body to cause hypofunction of islets of pancreas and insulin resistance. A series of metabolic disorder syndromes. Various acute and chronic complications brought about by diabetes seriously endanger people's health, and if they are not treated in time, they can be life-threatening. According to the survey of the World Health Organization, there are currently 160 million diabetic patients in the world, and there are more than 40 million diabetic patients in my country, accounting for about a quarter of the global diabetic patients, and the onset of diabetes te...

Examples

Embodiment 1

[0021] Embodiment 1, a kind of preparation of compound hand ginseng pharmaceutical composition granule

[0022] The ratio of raw materials is: hand ginseng 180g, Tibetan celery 90g, Polygonatum 130g, Himalayan mirabilis 90g, Asparagus 130g, Cordyceps 30g, Cynomorium 90g, Tribulus terrestris 30g, horse urine bubble 10g, myrobalan 160g;

[0023] (1) Take ginseng, Tibetan celery, Polygonatum, Mirabilis Himalayan, Radix Asparagus, Cynomorium terrestris, Tribulus terrestris, horse urine foam, and myrobalan fruit according to the composition ratio of raw materials; the volume concentration of adding 8 times the total weight of medicinal materials is 70% The ethanol solution was refluxed and extracted twice, each time for 2 hours, filtered, and the dregs A were used for later use, the ethanol extract was combined, the ethanol was concentrated under reduced pressure, and the concentration was continued to a thick paste with a relative density of 1.25 at 50°C to obtain ethanol extract B...

Embodiment 2

[0026] Embodiment 2, the preparation of a kind of medicine composition pellet of the effective part of compound hand ginseng

[0027] The composition ratio of the raw material medicine is: hand ginseng 197.3g, Tibetan lentil celery 98.0g, sealwort 133.3g, Himalaya mirabilis 98.0g, asparagus 133.3g, cordyceps 32.7g, Cynomorium 98.0g, tribulus terrestris 32.7g, horse urine bubble 13.6g g. Myrobalan 163.3g;

[0028] (1) According to the ratio of raw materials, 5 kinds of medicinal materials, including Tibetan celery, Himalayan mirabilis, Tribulus terrestris, horse urine bubble and myrobalan, were extracted twice with ethanol with a volume fraction of 50%. The amount of ethanol added for the first time was 8 times of the total weight of the original medicinal materials, the amount of ethanol added for the second time is 6 times of the total weight of the original medicinal materials, extracted for 2 hours each time, filtered, and combined with the ethanol extract to obtain ethanol...

Embodiment 3

[0034] Embodiment 3, a kind of preparation of compound hand ginseng pharmaceutical composition tablet

[0035] Ginseng 200g, Celery 100g, Polygonatum 135g, Mirabilis Himalayan 100g, Asparagus 135g, Cordyceps 35g, Cynomorium 100g, Tribulus terrestris 35g, Horse urine bubble 15g, Myrobalan 165g;

[0036] (1) Take ginseng, Tibetan celery, Polygonatum, Mirabilis Himalayan, Radix Asparagus, Cynomorium terrestris, Tribulus terrestris, horse urine foam, and myrobalan fruit according to the composition ratio of raw materials; add 6 times the total weight of medicinal materials to a volume concentration of 50% The ethanol solution was refluxed and extracted twice, each time for 2 hours, filtered, the dregs A were set aside, the ethanol extract was combined, the ethanol was concentrated under reduced pressure, and dried to obtain ethanol extract B;

[0037] (2) Take medicinal residue A, reflux extract 3 times with water 6 times the total weight of the medicinal materials, extract for 2 ...

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