Method for preparing 7-bromoisoquinoline

Abstract

The invention relates to a method for preparing 7-bromoisoquinoline. According to the method, a novel diazotization and bromine changing method is adopted, reaction is performed in a non-aqueous solvent, the method is easy to operate, the post-processing method is simple, the reaction condition is mild, namely the reaction is performed at normal temperature, and strong acid is not required. According to the method, the synthetic principle of related intermediate compounds is simple, the reaction condition is controllable, the yield is stable, and the method can be applied to industrial production.

Description

technical field [0001] The invention relates to a preparation method of a nitrogen-containing heterocyclic compound. Especially a kind of preparation method of 7-bromoisoquinoline. Background technique [0002] Quinoline and isoquinoline are important components of antibacterial drugs, and 7-bromoisoquinoline is an important drug intermediate, which is often introduced into other mother nuclei in the form of ligands. Excellent performance in all respects. It is currently available on the market, but at a high price ($8 / mg in 2007). Its synthetic method is mainly Pomeranz-Fritsch method, and this method mainly has two shortcomings: one, the reaction has by-product 5-bromoisoquinoline to produce, not only accounts for almost 50% each, and is difficult to separate; Low, around 20%. It is also because of these two major shortcomings that the market price of this product is extremely expensive. Contents of the invention [0003] The object of the present invention is to ov...

AI Technical Summary

Problems solved by technology

Currently available, but at a high price ($8 / mg in 2007)

Its synthetic method is mainly Pomeranz-Fritsch method, and this method mainly has two shortcomings: one, the reaction has by-product 5-bromoisoquinoline to produce, not only accounts for almost 50% each, and is difficult to separate; Low, around 20%

It is also because of these two shortcomings that the market price of this product is extremely expensive.

Images