New application of curcumin

A technology of curcumin and its use, which is applied in the field of prevention or/and treatment of delayed diarrhea caused by the antineoplastic drug irinotecan, and can solve the problem of reducing the intestinal concentration of lactone-type SN38, adverse consequences, and reducing the absorption of intestinal SN-38, etc. question

Active Publication Date: 2014-08-06
CHINA PHARM UNIV
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Problems solved by technology

But the organ toxicity of CsA limits its application in this area
④ Alkalinize the intestinal juice by oral alkaline preparations (such as sodium bicarbonate, magnesium oxide, alkaline water, etc.), so that the SN-38 lactone type (active type) moves to the carboxylic acid type (inactive type), reducing the lactone type The intestinal concentration of SN38 reduces the absorption of intestinal SN-38 (the intestinal absorption rate of lactone SN-38 is 10 times that of carboxylic acid type), exerts the therapeutic effect of delayed diarrhea, but long-term use may cause the acid-base balance in the body to be broken , with adverse consequences
[0016] 6. There is currently no report of curcumin being used to prevent or / and treat irinotecan-induced delayed diarrhea

Method used

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Embodiment Construction

[0026] The above-mentioned content of the present invention will be described in further detail below through specific embodiments in the form of examples, but it should not be understood that the scope of the above-mentioned theme of the present invention is limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0027] The therapeutic effect of embodiment curcumin on delayed diarrhea caused by irinotecan

[0028] 1. Experimental method

[0029] On the basis of the pre-test, 32 ICR male mice were randomly divided into 4 groups, with 8 mice in each group, and each mouse was housed in a single cage, with free access to food and water. The model group was intraperitoneally injected irinotecan 75mg / kg every day for four consecutive days; the curcumin group was intraperitoneally injected irinotecan 75mg / kg every day for four consecutive days, and at the same time intragastric...

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Abstract

The invention provides application of a curcumin on preparation of a medicine for preventing or / and treating a late diarrhea caused by an anti-tumor medicine, wherein the anti-tumor medicine is irinotecan or an active metabolite 7-thyl-10-hydroxycamptothecine (SN-38), and the late diarrhea is a severe diarrhea capable of lasting for 7 days appeared after the irinotecan is administrated for 24 hours. The curcumin provided by the invention is definite in efficacy; and with the adoption of the curcumin, the late diarrhea can be effectively relieved and the intestinal mucosa is protected.

Description

technical field [0001] The present invention relates to a new application of curcumin, in particular, the application in preventing or / and treating delayed diarrhea caused by antineoplastic drug irinotecan. Background technique [0002] Irinotecan (CPT-11 for short) is an antineoplastic drug widely used in clinical practice. It selectively inhibits topoisomerase I to exert cytotoxic effect. It is used for the first-line treatment of recurrence and deterioration of metastatic colorectal cancer after chemotherapy. This product can also be used alone or in combination with other drugs to treat small cell lung cancer, non-small cell lung cancer, malignant brain tumors, gastric cancer, pancreatic cancer, cervical cancer, ovarian cancer, etc. But the diarrhea (especially delayed diarrhea) caused by irinotecan seriously affects its clinical application. [0003] Diarrhea caused by irinotecan is divided into acute diarrhea and delayed diarrhea. Acute diarrhea mainly occurs within ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P1/12
Inventor 栾立标吴炎
Owner CHINA PHARM UNIV
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