Preparation method of N-methyl-pentylamine

A technology of methyl amylamine and n-amylamine, which is applied in the field of preparation of N-methyl amylamine, can solve the problems of long process route, influence on product promotion and application, low yield and the like, and achieves stable process and high yield. High, simple route effect
CN103012155AInactive Publication Date: 2013-04-03张家港市大伟助剂有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
张家港市大伟助剂有限公司
Publication Date
2013-04-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of N-methyl-pentylamine, which comprises the following steps of: adding anhydrous methylbenzene, n-pentylamine and benzaldehyde in a reactor, heating to reflux for 30-40minutes; evaporating to remove a solvent, cooling a residue to 0-5 DEG C, adding an anhydrous methylbenzene solution of dimethyl sulfate under the condition that the temperature is preserved, heating to reflux for 20-25minutes, decompressing and removing methylbenzene and benzaldehyde; and cooling the left solution to -5-0 DEG C, adding solid KOH, regulating pH to be 8.0-9.0, separating out an amine layer, and distilling at reduced pressure to obtain N-methyl-pentylamine. The preparation method disclosed by the invention is simple, low in requirement of equipment, stable in process, simple in route, high in yield, easy to post-process in a preparation process, and easy to industrialize.
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Description

technical field

[0001] The invention belongs to the field of organic synthesis, and in particular relates to a preparation method of N-methylpentylamine. Background technique

[0002] N-methylpentylamine is an important intermediate for the synthesis of bisphosphonate drug ebendronic acid sodium, and the US patent synthesis adopts the catalytic hydrogenation method (the yield is only 49%).

[0003] At present, for the preparation of this compound, the process route is too long or the yield is too low, which affects the promotion and application of this product. It is urgent to find a preparation method with stable process, simple route and high yield. Contents of the invention

[0004] The technical problem to be solved by the present invention is to provide a preparation method of N-methylamylamine with stable process, simple route and high yield.

[0005] For solving the problems of the technologies described above, the technical solution adopted in the present inventio...

Claims

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